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Volumn 16, Issue 4, 2008, Pages 515-521

Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury

Author keywords

Antioxidant; Ascorbate; Cartilage; Extracellular superoxide dismutase; Glutathione; IL 6; Joint fluid; Osteoarthritis; Oxidative stress; Redox; SOD3; Synovial fluid; TGF beta; Urate

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYALURONIC ACID; INTERLEUKIN 6; NITRATE; REACTIVE OXYGEN METABOLITE; STEROID; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; URATE;

EID: 41149122197     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.09.001     Document Type: Article
Times cited : (94)

References (48)
  • 1
    • 0031968825 scopus 로고    scopus 로고
    • Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States
    • Lawrence R.C., Helmick C.G., Arnett F.C., Deyo R.A., Felson D.T., Giannini E.H., et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41 (1998) 778-799
    • (1998) Arthritis Rheum , vol.41 , pp. 778-799
    • Lawrence, R.C.1    Helmick, C.G.2    Arnett, F.C.3    Deyo, R.A.4    Felson, D.T.5    Giannini, E.H.6
  • 2
    • 0023891732 scopus 로고
    • Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work
    • Anderson J.J., and Felson D.T. Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol 128 (1988) 179-189
    • (1988) Am J Epidemiol , vol.128 , pp. 179-189
    • Anderson, J.J.1    Felson, D.T.2
  • 4
    • 0036171665 scopus 로고    scopus 로고
    • Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species
    • Del Carlo Jr. M., and Loeser R.F. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum 46 (2002) 394-403
    • (2002) Arthritis Rheum , vol.46 , pp. 394-403
    • Del Carlo Jr., M.1    Loeser, R.F.2
  • 5
    • 8444234314 scopus 로고    scopus 로고
    • Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals
    • Agarwal S., Deschner J., Long P., Verma A., Hofman C., Evans C.H., et al. Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum 50 (2004) 3541-3548
    • (2004) Arthritis Rheum , vol.50 , pp. 3541-3548
    • Agarwal, S.1    Deschner, J.2    Long, P.3    Verma, A.4    Hofman, C.5    Evans, C.H.6
  • 6
    • 33750032729 scopus 로고    scopus 로고
    • Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    • Aigner T., Fundel K., Saas J., Gebhard P.M., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 54 (2006) 3533-3544
    • (2006) Arthritis Rheum , vol.54 , pp. 3533-3544
    • Aigner, T.1    Fundel, K.2    Saas, J.3    Gebhard, P.M.4    Haag, J.5    Weiss, T.6
  • 7
    • 0142012094 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase in biology and medicine
    • Fattman C.L., Schaefer L.M., and Oury T.D. Extracellular superoxide dismutase in biology and medicine. Free Radic Biol Med 35 (2003) 236-256
    • (2003) Free Radic Biol Med , vol.35 , pp. 236-256
    • Fattman, C.L.1    Schaefer, L.M.2    Oury, T.D.3
  • 8
    • 41149100005 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase (EC-SOD) binds to type I collagen and protects against oxidative fragmentation
    • Petersen S.V., Oury T.D., Ostergaard L., Valnickova Z., Wegrzyn J., Thogersen I.B., et al. Extracellular superoxide dismutase (EC-SOD) binds to type I collagen and protects against oxidative fragmentation. J Biol Chem 100 (2004) 13875-13880
    • (2004) J Biol Chem , vol.100 , pp. 13875-13880
    • Petersen, S.V.1    Oury, T.D.2    Ostergaard, L.3    Valnickova, Z.4    Wegrzyn, J.5    Thogersen, I.B.6
  • 9
    • 0028245094 scopus 로고
    • Immunocytochemical localization of extracellular superoxide dismutase in human lung
    • Oury T.D., Chang L.Y., Marklund S.L., Day B.J., and Crapo J.D. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest 70 (1994) 889-898
    • (1994) Lab Invest , vol.70 , pp. 889-898
    • Oury, T.D.1    Chang, L.Y.2    Marklund, S.L.3    Day, B.J.4    Crapo, J.D.5
  • 10
    • 0016170149 scopus 로고
    • Free radicals and inflammation: protection of synovial fluid by superoxide dismutase
    • McCord J.M. Free radicals and inflammation: protection of synovial fluid by superoxide dismutase. Science 185 (1974) 529-531
    • (1974) Science , vol.185 , pp. 529-531
    • McCord, J.M.1
  • 11
    • 0022444924 scopus 로고
    • Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides
    • Marklund S.L., Bjelle A., and Elmqvist L.G. Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides. Ann Rheum Dis 45 (1986) 847-851
    • (1986) Ann Rheum Dis , vol.45 , pp. 847-851
    • Marklund, S.L.1    Bjelle, A.2    Elmqvist, L.G.3
  • 12
    • 0347481187 scopus 로고    scopus 로고
    • Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels
    • Carlo Jr. M.D., and Loeser R.F. Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. Arthritis Rheum 48 (2003) 3419-3430
    • (2003) Arthritis Rheum , vol.48 , pp. 3419-3430
    • Carlo Jr., M.D.1    Loeser, R.F.2
  • 14
    • 0019787519 scopus 로고
    • Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis
    • Ames B.N., Cathcart R., Schwiers E., and Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78 (1981) 6858-6862
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 6858-6862
    • Ames, B.N.1    Cathcart, R.2    Schwiers, E.3    Hochstein, P.4
  • 15
    • 0035800889 scopus 로고    scopus 로고
    • Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite
    • Tarpey M.M., and Fridovich I. Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ Res 89 (2001) 224-236
    • (2001) Circ Res , vol.89 , pp. 224-236
    • Tarpey, M.M.1    Fridovich, I.2
  • 16
    • 0034234614 scopus 로고    scopus 로고
    • Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes
    • Xu Z., Buckley M.J., Evans C.H., and Agarwal S. Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes. J Immunol 165 (2000) 453-460
    • (2000) J Immunol , vol.165 , pp. 453-460
    • Xu, Z.1    Buckley, M.J.2    Evans, C.H.3    Agarwal, S.4
  • 18
    • 0036159528 scopus 로고    scopus 로고
    • Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation
    • Hedbom E., and Hauselmann H.J. Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci 59 (2002) 45-53
    • (2002) Cell Mol Life Sci , vol.59 , pp. 45-53
    • Hedbom, E.1    Hauselmann, H.J.2
  • 19
    • 0035990526 scopus 로고    scopus 로고
    • Nitric oxide and blood pressure in mice lacking extracellular-superoxide dismutase
    • Jonsson L.M., Rees D.D., Edlund T., and Marklund S.L. Nitric oxide and blood pressure in mice lacking extracellular-superoxide dismutase. Free Radic Res 36 (2002) 755-758
    • (2002) Free Radic Res , vol.36 , pp. 755-758
    • Jonsson, L.M.1    Rees, D.D.2    Edlund, T.3    Marklund, S.L.4
  • 20
    • 0141864392 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice
    • Jung O., Marklund S.L., Geiger H., Pedrazzini T., Busse R., and Brandes R.P. Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice. Circ Res 93 (2003) 622-629
    • (2003) Circ Res , vol.93 , pp. 622-629
    • Jung, O.1    Marklund, S.L.2    Geiger, H.3    Pedrazzini, T.4    Busse, R.5    Brandes, R.P.6
  • 21
    • 0035890010 scopus 로고    scopus 로고
    • Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment
    • Fattman C.L., Chu C.T., Kulich S.M., Enghild J.J., and Oury T.D. Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment. Free Radic Biol Med 31 (2001) 1198-1207
    • (2001) Free Radic Biol Med , vol.31 , pp. 1198-1207
    • Fattman, C.L.1    Chu, C.T.2    Kulich, S.M.3    Enghild, J.J.4    Oury, T.D.5
  • 23
    • 0343090850 scopus 로고    scopus 로고
    • Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells
    • Stralin P., and Marklund S.L. Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells. Atherosclerosis 151 (2000) 433-441
    • (2000) Atherosclerosis , vol.151 , pp. 433-441
    • Stralin, P.1    Marklund, S.L.2
  • 24
    • 23944446547 scopus 로고    scopus 로고
    • Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells
    • McEligot A.J., Yang S., and Meyskens Jr. F.L. Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells. Annu Rev Nutr 25 (2005) 261-295
    • (2005) Annu Rev Nutr , vol.25 , pp. 261-295
    • McEligot, A.J.1    Yang, S.2    Meyskens Jr., F.L.3
  • 25
    • 0034190367 scopus 로고    scopus 로고
    • Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB
    • Janssen-Heininger Y.M., Poynter M.E., and Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28 (2000) 1317-1327
    • (2000) Free Radic Biol Med , vol.28 , pp. 1317-1327
    • Janssen-Heininger, Y.M.1    Poynter, M.E.2    Baeuerle, P.A.3
  • 26
    • 0030158925 scopus 로고    scopus 로고
    • Superoxide dismutase activity in arthropathy: its role and measurement in the joints
    • Sumii H., Inoue H., Onoue J., Mori A., Oda T., and Tsubokura T. Superoxide dismutase activity in arthropathy: its role and measurement in the joints. Hiroshima J Med Sci 45 (1996) 51-55
    • (1996) Hiroshima J Med Sci , vol.45 , pp. 51-55
    • Sumii, H.1    Inoue, H.2    Onoue, J.3    Mori, A.4    Oda, T.5    Tsubokura, T.6
  • 27
    • 0020082109 scopus 로고
    • A remarkable increase of superoxide dismutase activity in synovial fluid of patients with rheumatoid arthritis
    • Igari T., Kaneda H., Horiuchi S., and Ono S. A remarkable increase of superoxide dismutase activity in synovial fluid of patients with rheumatoid arthritis. Clin Orthop Relat Res (1982) 282-287
    • (1982) Clin Orthop Relat Res , pp. 282-287
    • Igari, T.1    Kaneda, H.2    Horiuchi, S.3    Ono, S.4
  • 28
    • 30544442656 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint
    • Ostalowska A., Birkner E., Wiecha M., Kasperczyk S., Kasperczyk A., Kapolka D., et al. Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint. Osteoarthritis Cartilage 14 (2006) 139-145
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 139-145
    • Ostalowska, A.1    Birkner, E.2    Wiecha, M.3    Kasperczyk, S.4    Kasperczyk, A.5    Kapolka, D.6
  • 29
    • 0022276120 scopus 로고
    • The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA)
    • Lunec J., and Blake D.R. The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA). Free Radic Res Commun 1 (1985) 31-39
    • (1985) Free Radic Res Commun , vol.1 , pp. 31-39
    • Lunec, J.1    Blake, D.R.2
  • 30
    • 0034531762 scopus 로고    scopus 로고
    • In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes
    • Zheng S.X., Mouithys-Mickalad A., Deby-Dupont G.P., Deby C.M., Maroulis A.P., Labasse A.H., et al. In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes. Osteoarthritis Cartilage 8 (2000) 419-425
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 419-425
    • Zheng, S.X.1    Mouithys-Mickalad, A.2    Deby-Dupont, G.P.3    Deby, C.M.4    Maroulis, A.P.5    Labasse, A.H.6
  • 31
    • 0030589104 scopus 로고    scopus 로고
    • Fibronectin fragment mediated cartilage chondrolysis. I. Suppression by anti-oxidants
    • Homandberg G.A., Hui F., and Wen C. Fibronectin fragment mediated cartilage chondrolysis. I. Suppression by anti-oxidants. Biochim Biophys Acta 1317 (1996) 134-142
    • (1996) Biochim Biophys Acta , vol.1317 , pp. 134-142
    • Homandberg, G.A.1    Hui, F.2    Wen, C.3
  • 32
    • 0030589067 scopus 로고    scopus 로고
    • Fibronectin fragment mediated cartilage chondrolysis. II. Reparative effects of anti-oxidants
    • Homandberg G.A., Hui F., and Wen C. Fibronectin fragment mediated cartilage chondrolysis. II. Reparative effects of anti-oxidants. Biochim Biophys Acta 1317 (1996) 143-148
    • (1996) Biochim Biophys Acta , vol.1317 , pp. 143-148
    • Homandberg, G.A.1    Hui, F.2    Wen, C.3
  • 33
    • 0030728436 scopus 로고    scopus 로고
    • Articular chondrocytes and synoviocytes in culture: influence of antioxidants on lipid peroxidation and proliferation
    • Kurz B., and Schunke M. Articular chondrocytes and synoviocytes in culture: influence of antioxidants on lipid peroxidation and proliferation. Anat Anz 179 (1997) 439-446
    • (1997) Anat Anz , vol.179 , pp. 439-446
    • Kurz, B.1    Schunke, M.2
  • 34
    • 0030041928 scopus 로고    scopus 로고
    • Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes
    • Teixeira C.C., Shapiro I.M., Hatori M., Rajpurohit R., and Koch C. Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes. Biochem J 314 Pt 1 (1996) 21-26
    • (1996) Biochem J , vol.314 , Issue.PART 1 , pp. 21-26
    • Teixeira, C.C.1    Shapiro, I.M.2    Hatori, M.3    Rajpurohit, R.4    Koch, C.5
  • 35
    • 0036153745 scopus 로고    scopus 로고
    • Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1 N mice
    • Kurz B., Jost B., and Schunke M. Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1 N mice. Osteoarthritis Cartilage 10 (2002) 119-126
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 119-126
    • Kurz, B.1    Jost, B.2    Schunke, M.3
  • 36
    • 0025740098 scopus 로고
    • Superoxide dismutase and catalase activities in the growth cartilage: relationship between oxidoreductase activity and chondrocyte maturation
    • Matsumoto H., Silverton S.F., Debolt K., and Shapiro I.M. Superoxide dismutase and catalase activities in the growth cartilage: relationship between oxidoreductase activity and chondrocyte maturation. J Bone Miner Res 6 (1991) 569-574
    • (1991) J Bone Miner Res , vol.6 , pp. 569-574
    • Matsumoto, H.1    Silverton, S.F.2    Debolt, K.3    Shapiro, I.M.4
  • 37
    • 0018860867 scopus 로고
    • A trial of intraarticular orgotein, a superoxide dismutase, in experimentally-induced osteoarthritis
    • Rosner I.A., Goldberg V.M., Getzy L., and Moskowitz R.W. A trial of intraarticular orgotein, a superoxide dismutase, in experimentally-induced osteoarthritis. J Rheumatol 7 (1980) 24-29
    • (1980) J Rheumatol , vol.7 , pp. 24-29
    • Rosner, I.A.1    Goldberg, V.M.2    Getzy, L.3    Moskowitz, R.W.4
  • 38
    • 0028167933 scopus 로고
    • Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage
    • Fukuda K., Dan H., Saitoh M., Takayama M., and Tanaka S. Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage. Agents Actions 42 (1994) 71-73
    • (1994) Agents Actions , vol.42 , pp. 71-73
    • Fukuda, K.1    Dan, H.2    Saitoh, M.3    Takayama, M.4    Tanaka, S.5
  • 39
    • 23844538081 scopus 로고    scopus 로고
    • Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis
    • Yazar M., Sarban S., Kocyigit A., and Isikan U.E. Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis. Biol Trace Elem Res 106 (2005) 123-132
    • (2005) Biol Trace Elem Res , vol.106 , pp. 123-132
    • Yazar, M.1    Sarban, S.2    Kocyigit, A.3    Isikan, U.E.4
  • 40
    • 0034963331 scopus 로고    scopus 로고
    • Kashin-Beck disease: from etiology to prevention or from prevention to etiology?
    • Sudre P., and Mathieu F. Kashin-Beck disease: from etiology to prevention or from prevention to etiology?. Int Orthop 25 (2001) 175-179
    • (2001) Int Orthop , vol.25 , pp. 175-179
    • Sudre, P.1    Mathieu, F.2
  • 41
    • 0019865016 scopus 로고
    • Experimentally induced osteoarthritis in guinea pigs: metabolic responses in articular cartilage to developing pathology
    • Schwartz E.R., Oh W.H., and Leveille C.R. Experimentally induced osteoarthritis in guinea pigs: metabolic responses in articular cartilage to developing pathology. Arthritis Rheum 24 (1981) 1345-1355
    • (1981) Arthritis Rheum , vol.24 , pp. 1345-1355
    • Schwartz, E.R.1    Oh, W.H.2    Leveille, C.R.3
  • 42
    • 2642566167 scopus 로고    scopus 로고
    • Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model
    • Kraus V.B., Huebner J.L., Stabler T., Flahiff C.M., Setton L.A., Fink C., et al. Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. Arthritis Rheum 50 (2004) 1822-1831
    • (2004) Arthritis Rheum , vol.50 , pp. 1822-1831
    • Kraus, V.B.1    Huebner, J.L.2    Stabler, T.3    Flahiff, C.M.4    Setton, L.A.5    Fink, C.6
  • 43
    • 33646022817 scopus 로고    scopus 로고
    • Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation
    • Gaut J.P., Belaaouaj A., Byun J., Roberts II L.J., Maeda N., Frei B., et al. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic Biol Med 40 (2006) 1494-1501
    • (2006) Free Radic Biol Med , vol.40 , pp. 1494-1501
    • Gaut, J.P.1    Belaaouaj, A.2    Byun, J.3    Roberts II, L.J.4    Maeda, N.5    Frei, B.6
  • 45
    • 0036913674 scopus 로고    scopus 로고
    • High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years
    • Lang C.A., Mills B.J., Lang H.L., Liu M.C., Usui W.M., Richie Jr. J., et al. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. J Lab Clin Med 140 (2002) 413-417
    • (2002) J Lab Clin Med , vol.140 , pp. 413-417
    • Lang, C.A.1    Mills, B.J.2    Lang, H.L.3    Liu, M.C.4    Usui, W.M.5    Richie Jr., J.6
  • 46
    • 0026467074 scopus 로고
    • Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases
    • Farrell A.J., Blake D.R., Palmer R.M., and Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 51 (1992) 1219-1222
    • (1992) Ann Rheum Dis , vol.51 , pp. 1219-1222
    • Farrell, A.J.1    Blake, D.R.2    Palmer, R.M.3    Moncada, S.4
  • 47
    • 0033696610 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis
    • Kaneko S., Satoh T., Chiba J., Ju C., Inoue K., and Kagawa J. Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther 6 (2000) 71-79
    • (2000) Cytokines Cell Mol Ther , vol.6 , pp. 71-79
    • Kaneko, S.1    Satoh, T.2    Chiba, J.3    Ju, C.4    Inoue, K.5    Kagawa, J.6
  • 48
    • 0033194771 scopus 로고    scopus 로고
    • TGF-beta and osteoarthritis: in vivo veritas?
    • Pujol J.P. TGF-beta and osteoarthritis: in vivo veritas?. Osteoarthritis Cartilage 7 (1999) 439-440
    • (1999) Osteoarthritis Cartilage , vol.7 , pp. 439-440
    • Pujol, J.P.1


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