System development for generating homogeneous cell suspensions and transporting them in microfluidic devices

Engineering in Life Sciences

Volumn 8, Issue 1, 2008, Pages 49-55

  Schumacher, Jens T ^a   Grodrian, A ^a   Lemke, K ^a   Romer R ^a   Metze, J ^a  

^a Institut fur Bioprozess und Analysenmesstechnik eV   (Germany)

Author keywords

Microfluidic; Mixing; Process control; Suspensions

Indexed keywords

MIXING; PROCESS CONTROL; SUSPENSIONS (FLUIDS);

CELL SUSPENSIONS; MINIATURIZED BIOLOGICAL TEST ASSAYS;

MICROFLUIDICS;

MICROFLUIDICS; MIXING; PROCESS CONTROL; SUSPENSIONS (FLUIDS);

ASSAY; MIXING; PROCESSING; YEAST;

ACCURACY; ANALYTICAL EQUIPMENT; ANALYZER; ANIMAL CELL; ARTICLE; AUTOMATION; BIOASSAY; BIOCHIP; CELL ASSAY; CELL LOSS; CELL SUSPENSION; CELL TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; FEASIBILITY STUDY; FUNGAL CELL; HYBRIDOMA; MAMMAL CELL; MICROFLUIDICS; MOUSE; NONHUMAN; PROCESS CONTROL; TUMOR CELL;

MAMMALIA;

EID: 41149114154     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.200720224     Document Type: Article

References (19)

1. D. Castel, A. Pitaval, M.-A. Debily, X. Gidrol, Cell microarrays in drug discovery, Drug Disc. Today 2006, 11, 616-622.
2. S. Kumar, C. Wittmann, E. Heinzle, Minibioreactors, Biotechnol. Lett. 2004, 26, 1-10.
3. A. Reininger-Mack, H. Thielecke, A. A. Robitzki, 3D-biohybrid systems: applications in drug screening, Trends Biotechnol. 2002, 20, 56-61.
4. C. Haber, Microfluidics in commercial applications: an industry perspective, Lab Chip 2006, 6, 1118-1121.
5. F.-U. Gast, P. S. Dittrich, P. Schwille, M. Weigel, M. Mertig, J. Opitz, The microscopy cell (MicCell), a versatile modular flowthrough system for cell biology, biomaterial research, and nanotechnology, Microfluid Nanofluid 2006, 2, 21-36.
6. B. Wolf, M. Kraus, M. Brischwein, R. Ehret, W. Baumann, M. Lehmann et al., Biofunctional hybrid structures-cell-silicon hybrids for applications in biomedicine and bioinformatics, Bioelectrochem. Bioenerg. 1998, 46, 215-225.
7. H. L. T. Lee, P. Boccazzi, R. J. Ram, A. J. Sinskey, Microbioreactor arrays with integrated mixers and fluid injectors for high throughput experimentation with pH and dissolved oxygen control, Lab Chip 2006, 6, 1229-1235.
8. M. Brischwein, E. R. Motrescu, E. Cabala, A. M. Otto, H. Grothe, B. Wolf, Functional cellular assays with multiparametric silicon sensor chips, Lab Chip 2003, 3, 234-240.
9. A. R. Wheeler, W. R. Throndset, R. J. Whelan, A. M. Leach, R. N. Zare, Y. H. Liao et al., Microfluidic device for single-cell analysis, Anal. Chem. 2003, 75, 3581-3586.
10. A. Grodrian, J. Metze, T. Henkel, K. Martin, M. Roth, J. M. Köhler, Segmented flow generation by chip reactors for highly parallelized cell cultivation, Biosens. Bioelectron. 2004, 19, 1421-1428.
11. K. Martin, T. Henkel, V. Baier, A. Grodrian, T. Schón, M. Roth et al., Generation of larger numbers of separated microbial populations by cultivation in segmented-flow microdevices, Lab Chip 2003, 3, 202-207.
12. M. Valcarcel, M. D. Luque de Castro, Flow-Injection Analysis: Principles and Applications, Ellis Horwood Limited, Chichester (UK) 1987.
13. T. Henkel, T. Bermig, M. Kielpinski, A. Grodrian, J. Metze, J. M. Köhler, Chip modules for generation and manipulation of fluid segments for microserial flow processes, Chem. Eng. J. 2004, 101, 439-445.
14. C. Vasudevan, N. Fursov, P. Maunder, M. Cong, M. Federici, J. R. Haskins et al., Improving high-content screening assay performance by using division-arrested cells, Assay Drug Dev. Technol. 2005, 3, 515-523.
15. K. A. Giuliano, J. R. Haskins, D. L. Taylor, Advances in high content screening for drug discovery, Assay Drug Dev. Technol. 2003, 1, 565-577.
16. Tricumed GmbH, Infusionspumpe, Deutsches Gebrauchsmuster DE 269 22 313 U I, 1997.
17. K. Urich, Syringes and injectors incorporating magnetic fluid agitation devices, European Patent EP 1 107 804 B1, 2007.
18. Institut für Bioprozess- und Analysenmesstechnik e.V., Vorrichtung zur Durchmischung mindestens einer Substanz, Deutsches Gebrauchsmuster 20 2006 006 542, 2006.
19. A. Buschmann, T. Kuczius, W. Bodemer, M. H. Groschup, Cellular prion proteins of mammalian species display an intrinsic partial proteinase K resistance, Biochem. Biophys. Res. Commun. 1998, 253 (3), 693-702.