Gonadoblastoma-associated mixed germ cell tumour in 46,XY complete gonadal dysgenesis (Swyer syndrome): Analysis of Y chromosomal genotype and OCT3/4 and TSPY expression profile

Histopathology

Volumn 52, Issue 5, 2008, Pages 644-646

  Ng, S B ^a   Yong, M H ^b   Knight, L A ^b   Lee, V K M ^b   Nadarajah, S ^b   Stoop, H ^c   Looijenga, L H J ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^c JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; TESTIS SPECIFIC PROTEIN Y; UNCLASSIFIED DRUG;

ADOLESCENT; CASE REPORT; DYSGERMINOMA; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTYPE; GERM CELL TUMOR; GONADAL DYSGENESIS; GONADOBLASTOMA; HERMAPHRODITISM; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KARYOTYPE 46,XY; LETTER; PRIMARY AMENORRHEA; PRIORITY JOURNAL; SEMINOMA; SEXUAL MATURATION; Y CHROMOSOME;

ADOLESCENT; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN, Y; FEMALE; GONADAL DYSGENESIS, 46,XY; GONADOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; NEOPLASMS, MULTIPLE PRIMARY; OCTAMER TRANSCRIPTION FACTOR-3; OVARIAN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 41149089157     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2008.02988.x     Document Type: Letter

References (7)

1. Looijenga LHJ, Hersmus R, Oosterhuis JW et al. Tumor risk in disorders of sex development (SDS). Best Pract. Res. Clin. Endocrinol. Metab. 2007 21 480 495.
2. Looijenga LH, Hersmus R, Gillis AJ et al. Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Res. 2006 66 290 302.
3. Page DC. Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads. Development 1987 101 (Suppl. 151 155.
4. Kersemaekers AM, Honecker F, Stoop H et al. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum. Pathol. 2005 36 512 521.
5. Li Y, Tabatabai ZL, Lee TL et al. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Hum. Pathol. 2007 38 1470 1481.
6. Oosterhuis JW, Looijenga LH. Testicular germ-cell tumours in a broader perspective. Nat. Rev. Cancer 2005 5 210 222.
7. Eble JN, Sauter G, Epstein JI, Sesterhenn IA eds. Pathology and genetics of tumours of the urinary system and male genital organs. Lyon, France : IARC Press, 2004.