Worse prognosis with gene mutations of beta-myosin heavy chain than myosin-binding protein C in Chinese patients with hypertrophic cardiomyopathy

Clinical Cardiology

Volumn 31, Issue 3, 2008, Pages 114-118

  Wang, Shuxia ^a   Zou, Yubao ^a   Fu, Chunyan ^b   Xu, Xiqi ^b   Wang, Jizheng ^b   Song, Lei ^b   Wang, Hu ^b   Chen, Jingzhou ^b   Wang, Jianwei ^b   Huan, Tujun ^a   Hui, Rutai ^a,b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b FUWAI HOSPITAL   (China)

Author keywords

Genotype; Hypertrophic cardiomyopathy; Prognosis

Indexed keywords

MYOSIN BINDING PROTEIN C; MYOSIN HEAVY CHAIN BETA;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; BETA MYOSIN HEAVY CHAIN GENE; CHINESE; CONTROLLED STUDY; DNA SEQUENCE; FOLLOW UP; GENE; GENE MUTATION; HEART LEFT VENTRICLE FAILURE; HETEROZYGOTE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; LIFESPAN; MAJOR CLINICAL STUDY; MYOSIN BINDING PROTEIN C GENE; PHENOTYPE; PROSPECTIVE STUDY; SUDDEN DEATH; SURGICAL TECHNIQUE;

ADULT; BASE SEQUENCE; CARDIOMYOPATHY, HYPERTROPHIC; CARRIER PROTEINS; CHINA; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MUTATION; MYOSIN HEAVY CHAINS; PHENOTYPE; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; VENTRICULAR MYOSINS;

EID: 41149088666     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.20151     Document Type: Article

References (14)

1. Seidman JG, Seidman C: The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms. Cell 2001;104:557-567
2. Maron BJ: Hypertrophic cardiomyopathy: a systematic review. JAMA 2002;287:1308-1320
3. Watkins H, Rosenzweig A, Hwang DS, Levi T, McKenna W, et al.: Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N Engl J Med 1992;326:1108-1114
4. Niimura H, Bachinski LL, Sangwatanaroj S, Seidman JG, Seidman CE: Mutation in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. N Engl J Med 1998;338:1248-1257
5. Van Driest SL, Vasile VC, Onimen SR, Will ML, Tajik AJ, et al.: Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. J Am Coll Cardiol 2004;44:1903-1910
6. Song L, Zou Y, Wang J, Hui R: Mutations profile in Chinese patients with hypertrophic cardiomyopathy. Clin Chim Acta 2005;351:209-216
7. Zou Y, Song L, Wang Z, Ma A, Liu T, et al.: Prevalence of idiopathic hypertrophic cardiomyopathy in China: a population-based echocardiographic analysis of 8080 adults. Am J Med 2004;116:14-18
8. Woo A, Rakowski H, Liew JC, Zhao MS, Liew CC, et al.: Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis. Heart 2003;89:1179-1185
9. Maron MS, Olivotto I, Betocchi S, Casey SA, Lesser JR, et al.: Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 2003;348:295-303
10. Charron P, Dubourg O, Desnos M, Isnard R, Hagege A, et al.: Diagnostic value of electrocardiography and echocardiography for familial hypertrophic cardiomyopathy in a genotyped adult population. Circulation 1997;96:214-219
11. Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, et al., Task Force for the Diagnosis and Treatment: of Chronic Heart Failure of the European Society of Cardiology: Guidelines for the Diagnosis and Treatment of Chronic Heart Failure: Executive Summary (update 2005): The task force for the diagnosis and treatment of chronic heart failure of the European Society of Cardiology. Eur Heart J 2005;26:1115-1140
12. Ackerman MJ, Van Driest SL, Ommen SR, Will ML, Nishimura RA, et al.: Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: a comprehensive outpatient perspective. J Am Coll Cardiol 2002;39:2042-2048
13. Liu SX, Hu SJ, Sun J, Wang J, Wang XT, et al.: Characteristics of the beta myosin heavy chain gene Ala26Val mutation in a Chinese family with hypertrophic cardiomyopathy. Eur J Intern Med 2005;16:328-333
14. Fananapazir L, Epstein ND: Genotype-phenotype correlations in hypertrophic cardiomyopathy: insights provided by comparisons of kindreds with distinct and identical b-myosin heavy chain gene mutations. Circulation 1994;89:22-32