Total synthesis of the C-1027 chromophore core: Extremely facile enediyne formation through SmI2-mediated 1,2-elimination

Angewandte Chemie - International Edition

Volumn 47, Issue 9, 2008, Pages 1777-1779

  Inoue, Masayuki ^a   Ohashi, Isao ^b   Kawaguchi, Teruko ^b   Hirama, Masahiro ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Antitumor agents; Elimination; Enediynes; Natural products; Reduction

Indexed keywords

AROMATIC HYDROCARBONS; CHEMICAL REACTIONS; NUCLEIC ACIDS; ORGANIC ACIDS; SYNTHESIS (CHEMICAL);

ANTITUMOR AGENTS; ELIMINATION; ENEDIYNES; NATURAL PRODUCTS; REDUCTION;

CHROMOPHORES;

4 (TRIFLUOROMETHYL)BENZOIC ACID; 4-(TRIFLUOROMETHYL)BENZOIC ACID; AMINOGLYCOSIDE; ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; DRUG DERIVATIVE; ENEDIYNE; TOLUENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; SYNTHESIS;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; DRUG DELIVERY SYSTEMS; ENEDIYNES; MOLECULAR STRUCTURE; TOLUENE;

EID: 41049115936     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200704842     Document Type: Article

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