Purine-containing cucurbitane triterpenoids from Cucurbita pepo cv dayangua

Phytochemistry

Volumn 69, Issue 6, 2008, Pages 1434-1438

  Wang, Da Cheng ^a   Xiang, Hua ^a   Li, Dan ^b   Gao, Hui yuan ^b   Cai, Hui ^a   Wu, Li Jun ^b   Deng, Xu Ming ^a  

^a JILIN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Adenine; Adenosine; Cucurbita pepo cv dayangua; Cucurbitaceae; Cucurbitane triterpenoids; Cytotoxic activity

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITANE; GLYCOSIDE; PURINE DERIVATIVE; TRITERPENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; FRUIT; HELA CELL; HUMAN; MOLECULAR GENETICS; SQUASH;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CUCURBITA; FRUIT; GLYCOSIDES; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PURINES; TRITERPENES;

CUCUMIS SATIVUS; CUCURBITA PEPO; CUCURBITACEAE;

EID: 41049107817     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2008.01.019     Document Type: Article

References (24)

1. Agil A., Miro M., Jimenez J., Aneiros J., Caracuel M.D., Garcia-Granados A., and Navarro M.C. Isolation of antihepatotoxic principle from the juice of Ecballium elaterium. Planta Med. 65 (1999) 673-675
2. Bauer R., and Wagner H. Cucurbitacinhaltige arzneidrogen: analyse und standardisierung von arzneidrogen und standardisierung von arzneidrogen und phytopraèparaten durch HPLC und andere chromatographische Verfahren (II). Dtsch. Apoth. Ztg. 123 (1983) 1313-1321
3. Blaskovich M.A., Sun J., Cantor A., Turkson J., Jove R., and Sebti S.M. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 (2003) 1270-1279
4. Chen J.C., Chiu M.H., Nie R.L., Cordell G.A., and Qiu S.X. Cucurbitacins and cucurbitane glycosides: structures and biological activities. Nat. Prod. Rep. 22 (2005) 386-399
5. Ding Y.L., Deng X.M., Wang X.L., Wang Zh.Q., and Zhang Y.P. Study on Newcastle disease virus effect of five traditional Chinese herbs. J. Trad. Chin. Vet. Med. 21 (2002) 3-4
6. Ge Sh., Wang D.Ch., Wu L.J., and Deng X.M. Triterpenes from the fruits of Cucurbita pepo cv Dayangua. J. Shengyang Pharm. U. 23 (2006) 55-59
7. Guha J., and Sen S.P. The cucurbitacins - a review. Plant Biochem. J. 2 (1975) 12-28
8. Jayaprakasam B., Seeram N.P., and Nair M.G. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett. 189 (2003) 11-16
9. Jones A.J., Grant D.M., Winkley M.W., and Robins R.K. Carbon-13 magnetic resonance XVII: pyrimidine and purine nucleosides. J. Am. Chem. Soc. 92 (1970) 4079-4087
10. Lavie D., and Glotter E. The cucurbitanes, a group of tetracyclic triterpenes. Prog. Chem. Nat. Prod. 29 (1971) 308-362
11. Molholland D.A., Sewram V., Osborne R., Pegel K.H., and Connolly J.D. Cucurbitane trieterpenoids from the leaves of Momordica foetida. Phytochemistry 45 (1997) 391-395
12. Oh H., Mun Y.J., Im S.J., Seung Y., Ho J., Lee H.S., and Woo W.H. Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. Planta Med. 68 (2002) 832-833
13. Peters R.R., Saleh T.F., Lora M., Patry C., de Brum-Fernandes A.J., Farias M.R., and Ribeiro-do-Valle R.M. Anti-inflammatory effects of the products from Wilbrandia bracteata on carrageenan-induced pleurisy in mice. Life Sci. 64 (1999) 2429-2437
14. Peters R.R., Krebsky P.B., Siqueira-Junior J.M., Rocha J.C.S., Bezerra M.M., Ribeiro R.A., de Brum-Fernandes A.J., Farias M.R., Castro da Rocha F.A., and Ribeiro-do-Valle R.M. Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata. Life Sci. 73 (2003) 2187-2197
15. Pryzek Z. Tetracyclic triterpenes. Part 2. Synthetic approach to cucurbitacins. J. Chem. Soc., Perkin Trans. 1 (1979) 1222-1226
16. Rong G.B., and Zhu Sh.Zh. Structure Determination of Organic Compounds-Tables of Spectral Data [M] (2002), Huadong Technology University Press, Shanghai p. 238
17. Sang S.M., Lao A., Wang H.C., and Chen Z. Furostanol saponins from Allium tuberosum. Phytochemistry 52 (1999) 1611-1615
18. Wang D.B. Chemistry of Nucleic Acid [M] (1959), Science Press, Beijing p. 8
19. Wang D.Ch., Ge Sh., Wu L.J., and Deng X.M. Structure determination of a cucurbitacin glycoside extracted from Cucurbita pepo cv Dayangua by 2D NMR. Chin. J. Magn. Reson. 22 (2005) 417-422
20. Wang X.L., Liu J., Chen Zh.B., Gao F., Liu J.X., and Wang X.Zh. Preliminary study on pharmacologically effect of Curcurbita pepo cv Dayanggua. J. Trad. Chin. Vet. Med. 20 (2001) 6-9
21. Wu Y., Li B.Zh., Tian R.H., Suo L.D., and Liu M.Y. Thin-layer chromatographic analysis of adenine metabolins in potato. Chin. J. Chromat. 14 (1996) 75-76
22. Yang S.T., Chen S.N., and Yang B.M. Cucurbita pepo cv Dayangua. Spec. Econ. Amin. Plant. 3 (2000) 3l
23. Yang B.M., Yang S.T., and Chen S.N. A preliminary study on the cultivating technique of Cucurbita pepo cv Dayangua. Spec. Econ. Amin. Plant 3 (2000) 28
24. Zhao P.P., Li B.M., and He L.Y. Studies on the method of determination of combined sugars in glycosides. Acta Pharma. Sinica 22 (1987) 70-74