Impaired cervical homeostasis upon selective ablation of RXRα in epithelial cells

Genesis

Volumn 46, Issue 1, 2008, Pages 19-28

  Ocadiz Delgado, R ^a   Castaneda Saucedo, E ^b   Indra, A K ^b,d   Hernandez Pando, R ^c   Gariglio, Patricio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

Cervical alterations; Conditional inactivation; Cre loxp; Homeostasis; RXR

Indexed keywords

RETINOID X RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMOID TUMOR; FEMALE; GENE EXPRESSION; HOMEOSTASIS; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; UTERINE CERVIX EPITHELIUM;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CERVIX UTERI; EPIDERMIS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEOSTASIS; LIGANDS; MICE; MICE, MUTANT STRAINS; MUTAGENESIS; MUTATION; RETINOID X RECEPTOR ALPHA;

MAMMALIA; MUS;

EID: 40949129982     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20357     Document Type: Article

References (39)

1. Adams JM, Cory S. 1998. The Bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326.
2. Ahuja HS, Szanto A, Nagy L, Davies PJ. 2003. The retinoid X receptor and its ligands: Versatile regulators of metabolic function, cell differentiation and cell death. J Biol Regul Homeost Agents 17:29-45.
3. Baudino TA, Maclean KH, Brennan J, Parganas E, Yang C, Aslanian A, Lees JA, Sherr CJ, Roussel MF, Cleveland JL. 2003- Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Mol Cell 11:905-914.
4. Beere HM. 2005. Death versus survival: Functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest 115:2633-2639.
5. Celli G, Darwiche N, De Luca LM. 1996. Estrogen induces retinoid receptor expression in mouse cervical epithelia. Exp Cell Res 226:273-282.
6. Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-945.
7. Darwiche N, Celli G, De Luca LM. 1994. Specificity of retinoid receptor gene expression in mouse cervical epithelia. Endocrinology 134:2018-2025.
8. Eischen CM, Roussel MF, Korsmeyer SJ, Cleveland JL. 2001. Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol 21:7653-7662.
9. El-Deiry WS, Takashi T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
10. Fisher GJ, Voorhees JJ. 1996. Molecular mechanisms of retinoid actions in skin. FASEB J 10:1002-1013.
11. Fuhrmann G, Rosenberger G, Grusch M, Klein N, Hofmann J, Krupitza G. 1999. The Myc dualism in growth and death. Mutat Res 437:205-217.
12. Gavrieli Y, Sherman Y, Ben-Sasson SA. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
13. Giguère V. 1999. Orphan nuclear receptors: From gene to function. Endocr Rev 20:689-725.
14. Inayama Y, Kitamura H, Shibagaki T, Usuda Y, Ito T, Nakatani Y, Kanisawa M. 1996. In vivo growth and differentiation potential of tracheal basal cells of rabbits in vitamin A deficiency. Int J Exp Pathol 77:89-97.
15. Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P. 2007. Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor α in epidermal keratinocytes. J Invest Dermatol 127:1250-1260.
16. Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, Metzger D. 1999. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases. Nucleic Acids Res 27:4324-4327.
17. Jetten AM, De Luca LM, Nelson K, Schroeder W, Burlingame S, Fujimoto W. 1996. Regulation of cornifin α expression in the vaginal and uterine epithelium by estrogen and retinoic acid. Mol Cell Endocrinol 123:7-15.
18. Kuhn R, Schwenk F, Aguet M, Rajewsky K. 1995. Inducible gene targeting in mice. Science 269:1427-1429.
19. Li M, Chiba H, Warot X, Messaddeq N, Gerard C, Chambon P, Metzger D. 2001. RXR-α ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 128:675-688.
20. Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P. 2000. Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis. Nature 407:633-636.
21. Li R, Waga S, Hannon GJ, Beach D, Stillman B. 1994. Differential effects of p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371:534-537.
22. Liu H, Zang C, Fenner MH, Liu D, Possinger K, Koeffler HP, Elstner E. 2006. Growth inhibition and apoptosis in human Philadelphia chromosome positive lymphoblastic leukemia cell lines by treatment with the dual PPARα/γ ligand TZD18. Blood 107:3683-3692.
23. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P. 1995. The nuclear receptor superfamily: The second decade. Cell 83:835-839.
24. Martinez A. 1998. Detection of mRNA in tissue sections by in situ RT-PCR. Cell Vis 5:70.
25. Metzger D, Indra AK, Li M, Chapellier B, Calleja C, Ghyselinck NB, Chambon P. 2003. Targeted conditional somatic mutagenesis in the mouse: Temporally-controlled knock out of retinoid receptors in epidermal keratinocytes. Methods Enzymol 364:379-408.
26. Mori M, Metzger D, Picaud S, Hindelang C, Simonutti M, Sahel J, Chambon P, Mark M. 2004. Retinal dystrophy resulting from ablation of RXR α in the mouse retinal pigment epithelium. Am J Pathol 164:701-710.
27. Nagy A. 2000. Cre recombinase: The universal reagent for genome tailoring. Genesis 26:99-109.
28. Nuovo GJ. 2001. Co-labeling using in situ PCR: A review. J Histochem Cytochem 49:1329-1339.
29. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. 2005. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:7043-7046.
30. Pelengaris S, Khan M. 2003. The many faces of c-Myc. Arch Biochem Biophys 416:129-136.
31. Pelengaris S, Rudolph B, Littlewood T. 2000. Action of Myc in vivo - Proliferation and apoptosis. Curr Opin Genet Dev 10:100-105.
32. Potokar M, Kreft M, Chowdhury HH, Vardjan N, Zorec R. 2006. Subcellular localization of Apaf-1 in apoptotic rat pituitary cells. Am J Physiol Cell Physiol 290:C672-C677.
33. Reichrath J, Munssinger T, Kerber A, Rochette-Egly C, Chambon P, Bahmer FA, Baum HP. 1995. In situ detection of retinoid-X receptor expression in normal and psoriatic human skin. Br J Dermatol 133:168-175.
34. Riley R, Duensing S, Brake T, Münger K, Lambert PF, Arbeit JM. 2003. Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res 63:4862-4871.
35. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
36. Secombe J, Pierce SB, Eisenman RN. 2004. Myc: A weapon of mass destruction. Cell 117:153-156.
37. Thomas A, El Rouby S, Reed JC, Krajewski S, Silber R, Potmesil M, Newcomb EW. 1996. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 12:1055-1062.
38. Weber P, Schuler M, Gerard C, Mark M, Metzger D, Chambon P. 2003. Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis. Biol Reprod 68:553-559.
39. Whitten WK. 1959. Occurrence of anoestrus in mice caged in groups. J Endocrinol 18:102-107.