Chemoradiation for Advanced Head and Neck Cancer: Potential for Improving Results to Match Those of Current Treatment Modalities for Early-Stage Tumors-Long-Term Results of Hyperfractionated Chemoradiation With Carbogen Breathing and Anemia Correction With Erythropoietin

International Journal of Radiation Oncology Biology Physics

Volumn 70, Issue 5, 2008, Pages 1382-1388

  Villar, Alfonso ^a   Martinez, Jose Carlos ^b   de Serdio, Jose Luis ^b  

^a Instituto Oncologico del Sureste   (Spain)

^b HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

Author keywords

Carbogen; Chemoradiation; Head and neck cancer; Hyperfractionation

Indexed keywords

PATIENT MONITORING; TOXICITY; TUMORS;

CHEMORADIATION; HYPERFRACTIONATION; NECK CANCER;

ONCOLOGY;

CARBOGEN; CARBOPLATIN; ERYTHROPOIETIN;

ADULT; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG TOLERABILITY; FEMALE; FEVER; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; HYPOPHARYNX CANCER; LEUKOCYTE DISORDER; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; MUCOSA INFLAMMATION; NASOPHARYNX CANCER; NECK DISSECTION; OROPHARYNX CANCER; PARENTERAL NUTRITION; PRIORITY JOURNAL; RASH; SALIVARY GLAND DISEASE; SKIN TOXICITY; TREATMENT RESPONSE;

ADMINISTRATION, INHALATION; ADULT; AGED; ANEMIA; ANTINEOPLASTIC AGENTS; CARBON DIOXIDE; CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; CLINICAL PROTOCOLS; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; ERYTHROPOIETIN, RECOMBINANT; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; OXYGEN; RADIATION INJURIES; RADIATION-SENSITIZING AGENTS; SALVAGE THERAPY;

EID: 40949122706     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.08.068     Document Type: Article

References (37)

1. Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354 (2006) 567-578
2. Seiwert T.Y., Salama J.K., and Vokes E.E. The chemoradiation paradigm in head and neck cancer. Nat Clin Pract Oncol 4 (2007) 156-171
3. Aisner J., Hiponia D., Conley B., et al. Combined modalities in the treatment of head-and-neck cancer. Semin Oncol 22 Suppl. 6 (1995) 28-34
4. Rosenthal D.I., and Carbone D.P. Taxol plus radiation for head-and-neck cancer. J Infus Chemother 5 (1995) 46-54
5. Beitler J.J., Smith R.V., Owen R.P., et al. Phase II clinical trial of parenteral hydroxyurea and hyperfractionated, accelerated, external beam radiation therapy in patients with advanced squamous cell carcinoma of the head and neck: Toxicity and efficacy with continuous ribonucleoside reductase inhibition. Head Neck 29 (2007) 18-25
6. Milano M.T., Vokes E.E., Kao J., et al. Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: Preliminary experience and future directions. Int J Oncol 28 (2006) 1441-1451
7. Machtay M., Rosenthal D.I., Hershock D., et al. Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: A University of Pennsylvania Phase II Trial. J Clin Oncol 20 (2002) 3964-3971
8. Horiot J.C., Bontemps C., Van den Bogaert W., et al. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head-and-neck cancer: Results of the EORTC 22851 randomized trial. Radiother Oncol 44 (1997) 111-121
9. Horiot J.C., Le Fur R.L., N'Guyen T., et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: Final analysis of a randomized trial of the EORTC Cooperative Group of Radiotherapy. Radiother Oncol 25 (1992) 231-241
10. Budach W., Hehr T., Budach V., et al. A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer 6 (2006) 28
11. Muggia F.M., and Glatstein E. Summary of investigations on platinum compounds and radiation therapy. Int J Radiat Oncol Biol Phys 5 (1979) 1407-1409
12. Skov K., and McPhail S. Interaction of platinum drugs with clinically relevant x-rays doses in mammalian cells: A comparison of cisplatin, carboplatin, iproplatin and tetraplatin. Int J Radiat Oncol Biol Phys 20 (1991) 221-225
13. Adelstein D.J. Oropharyngeal cancer: The role of chemotherapy. Curr Treat Options Oncol 4 (2003) 3-13
14. Brizel D.M., Dodge R.K., and Clough R. The importance of tumor oxygenation. Radiother Oncol 53 (1999) 113-117
15. Lavey R.S., and Dempsey W.H. Erythropoietin increases hemoglobin in cancer patients during radiation therapy. Int J Radiat Oncol Biol Phys 27 (1993) 1147-1152
16. Martinez J.C., Villar A., Cabezon M.A., et al. Hyperfractionated chemoradiation with carbogen breathing, with or without erythropoietin: a stepwise developed treatment schedule for advanced head and neck cancer. Int J Radiat Oncol Biol Phys 50 (2001) 47-53
17. Bush R.S., Jenkin R.D., Altt W.E., et al. Definitive evidence for hypoxic cell influencing cure in cancer therapy. Br J Cancer 37 Suppl. (1978) 302-306
18. Martin L., Lartigau E., Weeger P., et al. Changes in the oxygenation of head-and-neck tumors during carbogen breathing. Radiother Oncol 27 (1993) 123-130
19. Kaanders J.H.A.M., Pop L.A.M., Marres H.A.M., et al. Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer. Radiother Oncol 48 (1998) 115-122
20. Villar A., Martinez J.C., Perez M.D., et al. A phase I/II study on hyperfractionated chemoradiation using carboplatin as part of each fraction of treatment in locally far advanced head-and-neck cancer. Oral Oncol Eur J Cancer 31 (1995) 401-402
21. De Serdio J.L., Villar A., Martinez J.C., et al. Chemotherapy as a part of each treatment fraction in a twice-a-day hyperfractionated schedule: A new chemoradiotherapy approach for advanced head-and-neck cancer. Head Neck 20 (1998) 489-496
22. Villar A., De Serdio J.L., Martinez J.C., et al. Five years results of hyperfractionated chemoradiotherapy in advanced head-and-neck cancer. The First World Congress on Head-and-Neck Oncology (1998), Monduzzi Ed, Bologna, Italy p. 955-959
23. Henke M., Laszig R., Rube H., et al. Erythropoietin to treat head and neck cancer patients with anemia undergoing radiotherapy: Randomized, double-blind, placebo-controlled trial. Lancet 362 (2003) 1255-1260
24. Kaanders J.H., and Van der Kogel A.J. Erythropoietin to treat anemia in patients with head and neck cancer. Lancet 363 (2004) 78-79
25. Danish Head and Neck Cancer Group. Interim analysis of DAHANCA 10. Available at: http://www.dahanca.dk. Accessed July 2007.
26. Lappin T.R., Maxwell A.P., and Johnston P.G. Warning flags for erythropoiesis-stimulating agents and cancer associated anemia. The Oncologist 12 (2007) 362-365
27. Brizel D.M., Prosnitz R.G., Hunter S., et al. Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 58 (2004) 1418-1423
28. Sewall G.K., Palazzi-Churas K.L., Richards G.M., et al. Planned postradiotherapy neck dissection: Rationale and clinical outcomes. Laryngoscope 117 (2007) 121-128
29. Nguyen N.P., Vos P., Smith H.J., et al. Concurrent chemoradiation for locally advanced oropharyngeal cancer. Am J Otolaryngol 28 (2007) 3-8
30. Charboneau N., Gelinas M., del Vecchio P., et al. Primary radiotherapy for tonsillar carcinoma: A good alternative to a surgical approach. J Otolaryngol 35 (2006) 227-234
31. Selek U., Garden A.S., Morrison W.H., et al. Radiation therapy for early-stage carcinoma of the oropharynx. Int J Radiat Oncol Biol Phys 59 (2004) 743-751
32. Wang M.B., Kuber N., Kerner M.M., et al. Tonsillar carcinoma: analysis of treatment results. J Otolaryngol 27 (1998) 263-269
33. Mendenhall W.M., Morris C.G., Amdur R.J., et al. Definitive radiotherapy for tonsillar squamous cell carcinoma. Am J Clin Oncol 29 (2006) 290-297
34. Gabriele P., Orecchia R., Ragona R., et al. Results of radiotherapy in the treatment of 218 carcinomas of the tonsillar area. Radiol Med (Torino) 74 (1987) 321-327
35. Mendenhall W.M., Amdur R.J., Stringer S.P., et al. Radiation therapy for squamous cell carcinoma of the tonsillar region: A preferred alternative to surgery?. J Clin Oncol 18 (2000) 2219-2225
36. Czaja J.M., and Gluckman J.L. Surgical management of early-stage hypopharyngeal carcinoma. Ann Otol Laryngol 106 (1997) 909-913
37. Garden A.S., Morrison W.H., Calyman G.L., et al. Early cell carcinoma of the hypopharynx: Outcomes of treatment with radiation alone to the primary disease. Head Neck 18 (1996) 317-322