Formulation and characterisation of beads prepared from natural cyclodextrins and vegetable, mineral or synthetic oils

International Journal of Pharmaceutics

Volumn 354, Issue 1-2, 2008, Pages 88-94

  Trichard, L ^a   Fattal, E ^a   Le Bas, G ^a   Duchene D ^a   Grossiord, J L ^a   Bochot, A ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Beads; Cyclodextrins; Emulsions; Mineral oil; Silicone oil; Vegetable oil

Indexed keywords

ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; COSMETIC; CYCLODEXTRIN DERIVATIVE; EMOLLIENT AGENT; GAMMA CYCLODEXTRIN; MINERAL OIL; SOYBEAN OIL; VEGETABLE OIL; WATER;

ARTICLE; CHEMICAL COMPOSITION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; EMULSION; PRIORITY JOURNAL; VISCOSITY;

ALPHA-CYCLODEXTRINS; BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DOSAGE FORMS; DRUG CARRIERS; DRUG STABILITY; ELASTICITY; EMULSIONS; GAMMA-CYCLODEXTRINS; OILS; PARTICLE SIZE; PHASE TRANSITION; RHEOLOGY; VISCOSITY;

EID: 40949119509     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.10.029     Document Type: Article

References (15)

1. Bochot A., Trichard L., Le Bas G., Alphandary H., Grossiord J.-L., Duchêne D., and Fattal E. α-Cyclodextrin/oil beads: an innovative self-assembling system. Int. J. Pharm. 339 (2007) 121-129
2. Duchêne D., Bochot A., Yu S.C., Pépin C., and Seiller M. Cyclodextrins and emulsions. Int. J. Pharm. 266 (2003) 85-90
3. Kawasaki J., Satou D., Takagaki T., Nemoto T., and Kawaguchi A. Structural features of inclusion complexes of γ-cyclodextrin with various polymers. Polymer 48 (2007) 1127-1138
4. Le Bas G., and Ryzanek N. Structural aspects of cyclodextrins. In: Duchêne D. (Ed). Cyclodextrins and their Industrial Uses (1987), Editions de santé, Paris 105-130
5. 2O. Models for the blue amylose-iodine complex. J. Am. Chem. Soc. 102 (1980) 2710-2722
6. Okumura H., Okada M., Kawaguchi Y., and Harada A. Complex formation between poly(dimethylsiloxane) and cyclodextrins: new pseudo-polyrotaxanes containing inorganic polymers. Macromolecules 33 (2000) 4297-4298
7. Porbeni F.E., Edeki E.M., Shin I.D., and Tonelli A.E. Formation and characterization of the inclusion complexes between poly(dimethylsiloxane) and polyacrylonitrile and γ-cyclodextrin. Polymer 42 (2001) 6907-6912
8. Saalwächter K. An investigation of poly(dimethylsiloxane) chain dynamics and order in its inclusion compound with γ-cyclodextrin by fast-MAS solid-state NMR spectroscopy. Macromol. Rapid Commun. 23 (2002) 286-291
9. Saenger W., and Steiner T. Cyclodextrin inclusion complexes: host-guest interactions and hydrogen-bonding networks. Acta Crystallogr. A 54 (1998) 798-805
10. Shimada K., Ohe Y., Ohguni T., Kawano K., Ishii J., and Nakamura T. Emulsifying properties of alpha-, beta- and gamma-cyclodextrins. Nippon Shokuhin Kogyo Gakkaishi 38 (1991) 16-20
11. Shimada K., Kawano K., Ihsii J., and Nakamura T. Structure of inclusion complexes of cyclodextrins with triglyceride at vegetable oil/water interface. J. Food Sci. 57 (1992) 655-656
12. Trichard L., Fattal E., Besnard M., and Bochot A. α-Cyclodextrin/oil beads as a new carrier for improving the oral bioavailability of lipophilic drugs. J. Control Release 122 (2007) 47-53
13. Trichard L., Begoña Delgado-Charro M., Guy R.H., Fattal E., and Bochot A. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug. Pharm. Res. 25 (2008) 435-440
14. Wishnia A., and Lappi S.J. Effect or-modulated subunit associations in a model hydrophobic system. J. Mol. Biol. 82 (1974) 77-89
15. Yu S.C., Bochot A., Le Bas G., Chéron M., Grossiord J.L., Seiller M., and Duchêne D. Characteristics of O/W emulsions containing lipophilic molecules with cyclodextrins as emulsifiers. S.T.P. Pharma Sci. 11 (2001) 385-391