메뉴 건너뛰기




Volumn 25, Issue 1, 2008, Pages 51-56

Signalosomes as therapeutic targets

Author keywords

AKAP lbc; Heart; mAKAP; Signalosome; Therapeutic

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; SCAFFOLD PROTEIN; SIGNALOSOME; UNCLASSIFIED DRUG;

EID: 40949111015     PISSN: 10589813     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ppedcard.2007.11.012     Document Type: Article
Times cited : (20)

References (43)
  • 1
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke J., and Molkentin J. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7 (2006) 589-600
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 589-600
    • Heineke, J.1    Molkentin, J.2
  • 2
    • 34347403248 scopus 로고    scopus 로고
    • Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses
    • Clerk A., Cullingford T., Fuller S., et al. Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. J Cell Physiol 212 (2007) 311-322
    • (2007) J Cell Physiol , vol.212 , pp. 311-322
    • Clerk, A.1    Cullingford, T.2    Fuller, S.3
  • 3
    • 0035029169 scopus 로고    scopus 로고
    • Compartmentation of g protein-coupled signaling pathways in cardiac myocytes
    • Steinberg S., and Brunton L. Compartmentation of g protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol 41 (2001) 751-773
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 751-773
    • Steinberg, S.1    Brunton, L.2
  • 4
    • 33745181698 scopus 로고    scopus 로고
    • The where's and when's of kinase anchoring
    • Smith F., Langeberg L., and Scott J. The where's and when's of kinase anchoring. Trends Biochem Sci 31 (2006) 316-323
    • (2006) Trends Biochem Sci , vol.31 , pp. 316-323
    • Smith, F.1    Langeberg, L.2    Scott, J.3
  • 5
    • 34248597540 scopus 로고    scopus 로고
    • The mAKAP signalosome and cardiac myocyte hypertrophy
    • Bauman A., Michel J., Henson E., et al. The mAKAP signalosome and cardiac myocyte hypertrophy. IUBMB Life 59 (2007) 163-169
    • (2007) IUBMB Life , vol.59 , pp. 163-169
    • Bauman, A.1    Michel, J.2    Henson, E.3
  • 6
    • 33745014962 scopus 로고    scopus 로고
    • AKAP-Lbc: a molecular scaffold for the integration of cyclic AMP and Rho transduction pathways
    • Diviani D., Baisamy L., and Appert-Collin A. AKAP-Lbc: a molecular scaffold for the integration of cyclic AMP and Rho transduction pathways. Eur J Cell Biol 85 (2006) 603-610
    • (2006) Eur J Cell Biol , vol.85 , pp. 603-610
    • Diviani, D.1    Baisamy, L.2    Appert-Collin, A.3
  • 7
    • 31344481509 scopus 로고    scopus 로고
    • The pediatric cardiology pharmacopoeia: 2004 update
    • Barnes S., Shields B., Bonney W., et al. The pediatric cardiology pharmacopoeia: 2004 update. Pediatr Cardiol 25 (2004) 623-646
    • (2004) Pediatr Cardiol , vol.25 , pp. 623-646
    • Barnes, S.1    Shields, B.2    Bonney, W.3
  • 8
    • 0021023294 scopus 로고
    • Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes
    • Buxton I., and Brunton L. Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes. J Biol Chem 258 (1983) 10233-10239
    • (1983) J Biol Chem , vol.258 , pp. 10233-10239
    • Buxton, I.1    Brunton, L.2
  • 10
    • 2642705036 scopus 로고    scopus 로고
    • A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events
    • Fraser I., Tavalin S., Lester L., et al. A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J 17 (1998) 2261-2272
    • (1998) EMBO J , vol.17 , pp. 2261-2272
    • Fraser, I.1    Tavalin, S.2    Lester, L.3
  • 11
    • 33750804385 scopus 로고    scopus 로고
    • Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation
    • Hulme J., Westenbroek R., Scheuer T., et al. Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Proc Natl Acad Sci USA 103 (2006) 16574-16579
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16574-16579
    • Hulme, J.1    Westenbroek, R.2    Scheuer, T.3
  • 12
    • 0028927472 scopus 로고
    • Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum
    • McCartney S., Little B., Langeberg L., et al. Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum. J Biol Chem 270 (1995) 9327-9333
    • (1995) J Biol Chem , vol.270 , pp. 9327-9333
    • McCartney, S.1    Little, B.2    Langeberg, L.3
  • 13
    • 0032572584 scopus 로고    scopus 로고
    • A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart
    • Yang J., Drazba J., Ferguson D., et al. A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart. J Cell Biol 142 (1998) 511-522
    • (1998) J Cell Biol , vol.142 , pp. 511-522
    • Yang, J.1    Drazba, J.2    Ferguson, D.3
  • 14
    • 0034640113 scopus 로고    scopus 로고
    • PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
    • Marx S., Reiken S., Hisamatsu Y., et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101 (2000) 365-376
    • (2000) Cell , vol.101 , pp. 365-376
    • Marx, S.1    Reiken, S.2    Hisamatsu, Y.3
  • 15
    • 0032842848 scopus 로고    scopus 로고
    • mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes
    • Kapiloff M., Schillace R., Westphal A., et al. mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J Cell Sci 112 (1999) 2725-2736
    • (1999) J Cell Sci , vol.112 , pp. 2725-2736
    • Kapiloff, M.1    Schillace, R.2    Westphal, A.3
  • 16
    • 0034789448 scopus 로고    scopus 로고
    • mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope
    • Kapiloff M., Jackson N., and Airhart N. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci 114 (2001) 3167-3176
    • (2001) J Cell Sci , vol.114 , pp. 3167-3176
    • Kapiloff, M.1    Jackson, N.2    Airhart, N.3
  • 17
    • 12344259872 scopus 로고    scopus 로고
    • Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope
    • Pare G., Easlick J., Mislow J., et al. Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res 303 (2005) 388-399
    • (2005) Exp Cell Res , vol.303 , pp. 388-399
    • Pare, G.1    Easlick, J.2    Mislow, J.3
  • 18
    • 35748935532 scopus 로고    scopus 로고
    • Nesprin-1 and -2 are involved in the pathogenesis of Emery-Dreifuss muscular dystrophy and are critical for nuclear envelope integrity
    • Zhang Q., Bethmann C., Worth N., et al. Nesprin-1 and -2 are involved in the pathogenesis of Emery-Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum Mol Genet (2007)
    • (2007) Hum Mol Genet
    • Zhang, Q.1    Bethmann, C.2    Worth, N.3
  • 19
    • 0035901502 scopus 로고    scopus 로고
    • mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
    • Dodge K., Khouangsathiene S., Kapiloff M., et al. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J 20 (2001) 1921-1930
    • (2001) EMBO J , vol.20 , pp. 1921-1930
    • Dodge, K.1    Khouangsathiene, S.2    Kapiloff, M.3
  • 20
    • 33750720277 scopus 로고    scopus 로고
    • PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
    • Terrin A., Di Benedetto G., Pertegato V., et al. PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol 175 (2006) 441-451
    • (2006) J Cell Biol , vol.175 , pp. 441-451
    • Terrin, A.1    Di Benedetto, G.2    Pertegato, V.3
  • 21
    • 4344594414 scopus 로고    scopus 로고
    • PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex
    • Carlisle Michel J., Dodge K., Wong W., et al. PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Biochem J 381 (2004) 587-592
    • (2004) Biochem J , vol.381 , pp. 587-592
    • Carlisle Michel, J.1    Dodge, K.2    Wong, W.3
  • 22
    • 25644452031 scopus 로고    scopus 로고
    • The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
    • Dodge-Kafka K., Soughayer J., Pare G., et al. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437 (2005) 574-578
    • (2005) Nature , vol.437 , pp. 574-578
    • Dodge-Kafka, K.1    Soughayer, J.2    Pare, G.3
  • 23
    • 33947534858 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop
    • Yan C., Ding B., Shishido T., et al. Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. Circ Res 100 (2007) 510-519
    • (2007) Circ Res , vol.100 , pp. 510-519
    • Yan, C.1    Ding, B.2    Shishido, T.3
  • 24
    • 0035355360 scopus 로고    scopus 로고
    • Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
    • Nicol R., Frey N., Pearson G., et al. Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J 20 (2001) 2757-2767
    • (2001) EMBO J , vol.20 , pp. 2757-2767
    • Nicol, R.1    Frey, N.2    Pearson, G.3
  • 25
    • 0034595707 scopus 로고    scopus 로고
    • ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions
    • MacKenzie S., Baillie G., McPhee I., et al. ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions. J Biol Chem 275 (2000) 16609-16617
    • (2000) J Biol Chem , vol.275 , pp. 16609-16617
    • MacKenzie, S.1    Baillie, G.2    McPhee, I.3
  • 26
    • 0036950082 scopus 로고    scopus 로고
    • Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy
    • Manabe I., Shindo T., and Nagai R. Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res 91 (2002) 1103-1113
    • (2002) Circ Res , vol.91 , pp. 1103-1113
    • Manabe, I.1    Shindo, T.2    Nagai, R.3
  • 27
    • 33646924842 scopus 로고    scopus 로고
    • Cardiac ryanodine receptor phosphorylation: target sites and functional consequences
    • Bers D. Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. Biochem J 396 (2006) e1-e3
    • (2006) Biochem J , vol.396
    • Bers, D.1
  • 28
    • 31444432542 scopus 로고    scopus 로고
    • Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression
    • Wehrens X., Lehnart S., Reiken S., et al. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A 103 (2006) 511-518
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 511-518
    • Wehrens, X.1    Lehnart, S.2    Reiken, S.3
  • 29
    • 33746826872 scopus 로고    scopus 로고
    • 2+ store throughout cardiac myocyte
    • 2+ store throughout cardiac myocyte. Circ Res 99 (2006) 283-291
    • (2006) Circ Res , vol.99 , pp. 283-291
    • Wu, X.1    Bers, D.2
  • 30
    • 30544452653 scopus 로고    scopus 로고
    • The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling
    • Pare G., Bauman A., McHenry M., et al. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J Cell Sci 118 (2005) 5637-5646
    • (2005) J Cell Sci , vol.118 , pp. 5637-5646
    • Pare, G.1    Bauman, A.2    McHenry, M.3
  • 31
    • 4444382387 scopus 로고    scopus 로고
    • Calcium-calcineurin signaling in the regulation of cardiac hypertrophy
    • Wilkins B., and Molkentin J. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322 (2004) 1178-1191
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 1178-1191
    • Wilkins, B.1    Molkentin, J.2
  • 32
    • 34547166141 scopus 로고    scopus 로고
    • The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy
    • Appert-Collin A., Cotecchia S., Nenniger-Tosato M., et al. The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A 104 (2007) 10140-10145
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10140-10145
    • Appert-Collin, A.1    Cotecchia, S.2    Nenniger-Tosato, M.3
  • 33
    • 0026680801 scopus 로고
    • Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII- binding domain
    • Carr D., Hausken Z., Fraser I., et al. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII- binding domain. J Biol Chem 267 (1992) 13376-13382
    • (1992) J Biol Chem , vol.267 , pp. 13376-13382
    • Carr, D.1    Hausken, Z.2    Fraser, I.3
  • 34
    • 0035794551 scopus 로고    scopus 로고
    • A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes
    • Newlon M., Roy M., Morikis D., et al. A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J 20 (2001) 1651-1662
    • (2001) EMBO J , vol.20 , pp. 1651-1662
    • Newlon, M.1    Roy, M.2    Morikis, D.3
  • 35
    • 0035941212 scopus 로고    scopus 로고
    • AKAP-Lbc Anchors Protein Kinase A and Nucleates Galpha 12-selective Rho- mediated Stress Fiber Formation
    • Diviani D., Soderling J., and Scott J. AKAP-Lbc Anchors Protein Kinase A and Nucleates Galpha 12-selective Rho- mediated Stress Fiber Formation. J Biol Chem 276 (2001) 44247-44257
    • (2001) J Biol Chem , vol.276 , pp. 44247-44257
    • Diviani, D.1    Soderling, J.2    Scott, J.3
  • 36
    • 3543020962 scopus 로고    scopus 로고
    • Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex
    • Diviani D., Abuin L., Cotecchia S., et al. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J 23 (2004) 2811-2820
    • (2004) EMBO J , vol.23 , pp. 2811-2820
    • Diviani, D.1    Abuin, L.2    Cotecchia, S.3
  • 37
    • 4344598183 scopus 로고    scopus 로고
    • Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization
    • Jin J., Smith F., Stark C., et al. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 14 (2004) 1436-1450
    • (2004) Curr Biol , vol.14 , pp. 1436-1450
    • Jin, J.1    Smith, F.2    Stark, C.3
  • 38
    • 0037110460 scopus 로고    scopus 로고
    • Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy
    • Maruyama Y., Nishida M., Sugimoto Y., et al. Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Circ Res 91 (2002) 961-969
    • (2002) Circ Res , vol.91 , pp. 961-969
    • Maruyama, Y.1    Nishida, M.2    Sugimoto, Y.3
  • 39
    • 4344642877 scopus 로고    scopus 로고
    • AKAP-Lbc nucleates a protein kinase D activation scaffold
    • Carnegie G., Smith F., McConnachie G., et al. AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell 15 (2004) 889-899
    • (2004) Mol Cell , vol.15 , pp. 889-899
    • Carnegie, G.1    Smith, F.2    McConnachie, G.3
  • 40
    • 34447559636 scopus 로고    scopus 로고
    • Interfering with disease: a progress report on siRNA-based therapeutics
    • de Fougerolles A., Vornlocher H., Maraganore J., et al. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 6 (2007) 443-453
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 443-453
    • de Fougerolles, A.1    Vornlocher, H.2    Maraganore, J.3
  • 41
    • 33744992976 scopus 로고    scopus 로고
    • The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways
    • Dodge-Kafka K., and Kapiloff M. The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways. Eur J Cell Biol 85 (2006) 593-602
    • (2006) Eur J Cell Biol , vol.85 , pp. 593-602
    • Dodge-Kafka, K.1    Kapiloff, M.2
  • 42
    • 1842534887 scopus 로고    scopus 로고
    • Inhibitors of the calcineurin/NFAT pathway
    • Martinez-Martinez S., and Redondo J. Inhibitors of the calcineurin/NFAT pathway. Curr Med Chem 11 (2004) 997-1007
    • (2004) Curr Med Chem , vol.11 , pp. 997-1007
    • Martinez-Martinez, S.1    Redondo, J.2
  • 43
    • 34447127566 scopus 로고    scopus 로고
    • Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders
    • Yu H., van Berkel T., and Biessen E. Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders. Cardiovasc Drug Rev 25 (2007) 175-187
    • (2007) Cardiovasc Drug Rev , vol.25 , pp. 175-187
    • Yu, H.1    van Berkel, T.2    Biessen, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.