Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis

Arthritis Research and Therapy

Volumn 10, Issue 1, 2008, Pages

  Kauss, Tina ^a   Moynet, Daniel ^a   Rambert, Jérôme ^a   Al Kharrat, Abir ^a   Brajot, Stephane ^a   Thiolat, Denis ^a   Ennemany, Rachid ^b   Fawaz, Fawaz ^a   Djavad, M Djavad ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Eurotest   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 10 RECEPTOR BETA; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 4; NITRIC OXIDE; PROSTAGLANDIN E2; RANTES; RUTOSIDE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; AUTACOID; CYTOKINE;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHRONIC ARTHRITIS; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; DISEASE COURSE; EX VIVO STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MACROPHAGE ACTIVATION; NONHUMAN; PERITONEUM MACROPHAGE; QUANTITATIVE ANALYSIS; RAT; SUPERNATANT; TRANSCRIPTION REGULATION; ANIMAL; ARTHRITIS; CELL CULTURE; CHRONIC DISEASE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; LEWIS RAT; MACROPHAGE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BODY WEIGHT; CELLS, CULTURED; CHRONIC DISEASE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERLEUKIN-6; MACROPHAGES; MACROPHAGES, PERITONEAL; NITRIC OXIDE; RATS; RATS, INBRED LEW; RUTIN; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 40949103873     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2372     Document Type: Article

References (45)

1. Feldmann M Maini RN Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned? Annu Rev Immunol 2001, 19:163-196 10.1146/ annurev.immunol.19.1.163 11244034
2. Ma Y Pope RM The role of macrophages in rheumatoid arthritis Curr Pharm Des 2005, 11:569-580 10.2174/1381612053381927 15720276
3. Farrell AJ Blake DR Palmer RM Moncada S Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases Ann Rheum Dis 1992, 51:1219-1222 1012459 1466599
4. + blood monocytes and synovial tissue macrophages in rheumatoid arthritis Arthritis Rheum 2004, 50:1457-1467 10.1002/art.20219 15146415
5. + blood monocytes and joint inflammation in rheumatoid arthritis Arthritis Rheum 2002, 46:2578-2586 10.1002/art.10545 12384915
6. Mulherin D Fitzgerald O Bresnihan B Synovial tissue macrophage populations and articular damage in rheumatoid arthritis Arthritis Rheum 1996, 39:115-124 10.1002/art.1780390116 8546720
7. Nuki G Bresnihan B Bear MB McCabe D Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial Arthritis Rheum 2002, 46:2838-2846 10.1002/ art.10578 12428223
8. De Rycke L Baeten D Foell D Kruithof E Veys EM Roth J De Keyser F Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis J Pathol 2005, 206:17-27 10.1002/path.1758 15809977
9. Olsen NJ Stein CM New drugs for rheumatoid arthritis N Engl J Med 2004, 350:2167-2179 10.1056/NEJMra032906 15152062
10. Kumazawa Y Kawaguchi K Takimoto H Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha Curr Pharm Des 2006, 12:4271-4279 10.2174/ 138161206778743565 17100629
11. Wadworth AN Faulds D Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders Drugs 1992, 44:1013-1032 10.2165/ 00003495-199244060-00009 1282862
12. Comalada M Camuesco D Sierra S Ballester I Xaus J Galvez J Zarzuelo A In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway Eur J Immunol 2005, 35:584-592 10.1002/eji.200425778 15668926
13. Mamani-Matsuda M Rambert J Malvy D Lejoly-Boisseau H Daulouede S Thiolat D Coves S Courtois P Vincendeau P Mossalayi MD Quercetin induces apoptosis of Trypanosoma brucei gambiense and decreases the proinflammatory response of human macrophages Antimicrob Agents Chemother 2004, 48:924-929 353125 14982785 10.1128/AAC.48.3.924-929.2004
14. Khanna D Sethi G Ahn KS Pandey MK Kunnumakkara AB Sung B Aggarwal A Aggarwal BB Natural products as a gold mine for arthritis treatment Curr Opin Pharmacol 2007, 7:344-351 10.1016/j.coph.2007.03.002 17475558
15. Chen CC Chow MP Huang WC Lin YC Chang YJ Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: Structure-activity relationships Mol Pharmacol 2004, 66:683-693 10.1124/mol.104.001206 15322261
16. Volate SR Davenport DM Muga SJ Wargovich MJ Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin) Carcinogenesis 2005, 26:1450-1456 10.1093/ carcin/bgi089 15831530
17. Zhou SF Xue CC Yu XQ Wang G Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: An update Curr Drug Metab 2007, 8:526-553 10.2174/138920007781368863 17691916
18. Cruz T Galvez J Ocete MA Crespo ME Sanchez de Medina LHF Zarzuelo A Oral administration of rutoside can ameliorate inflammatory bowel disease in rats Life Sci 1998, 62:687-695 10.1016/S0024-3205(97)01164-8 9472728
19. Kwon KH Murakami A Tanaka T Ohigashi H Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: Attenuation of pro-inflammatory gene expression Biochem Pharmacol 2005, 69:395-406 10.1016/j.bcp.2004.10.015 15652231
20. Rotelli AE Guardia T Juarez AO de la Rocha NE Pelzer LE Comparative study of flavonoids in experimental models of inflammation Pharmacol Res 2003, 48:601-606 10.1016/S1043-6618(03)00225-1 14527825
21. Ostrakhovitch EA Afanas'ev IB Oxidative stress in rheumatoid arthritis leukocytes: Suppression by rutin and other antioxidants and chelators Biochem Pharmacol 2001, 62:743-746 10.1016/S0006-2952(01)00707-9 11551519
22. Vouldoukis I Riveros-Moreno V Dugas B Ouaaz F Becherel P Debre P Moncada S Mossalayi MD The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/ CD23 surface antigen Proc Natl Acad Sci USA 1995, 92:7804-7808 41234 7544003 10.1073/pnas.92.17.7804
23. + normal human keratinocytes J Clin Invest 1994, 93:2275-2279 294386 8182161 10.1172/JCI117227
24. SuperArray Bioscience Corporation homepage http://www.superarray.com
25. Kolb JP Paul-Eugene N Damais C Yamaoka K Drapier JC Dugas B Interleukin-4 stimulates cGMP production by IFN-gamma-activated human monocytes. Involvement of the nitric oxide synthase pathway J Biol Chem 1994, 269:9811-9816 7511593
26. Stenger S Donhauser N Thuring H Rollinghoff M Bogdan C Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase J Exp Med 1996, 183:1501-1514 10.1084/jem.183.4.1501 8666908
27. Feldmann M Steinman L Design of effective immunotherapy for human autoimmunity Nature 2005, 435:612-619 10.1038/nature03727 15931214
28. Koga T Pearson CM Immunogenicity and arthritogenicity in the rat of an antigen from Mycobacterium tuberculosis wax D J Immunol 1973, 111:599-608 4197988
29. Willems AM Bruynzeel AM Kedde MA van Groeningen CJ Bast A van der Vijgh WJ A phase I study of monohydroxyethylrutoside in healthy volunteers Cancer Chemother Pharmacol 2006, 57:678-684 10.1007/s00280-005-0083-7 16136309
30. Mazzon E Serraino I Li JH Dugo L Caputi AP Zhang J Cuzzocrea S GPI a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation Eur J Pharmacol 6150, 415:85-94 10.1016/S0014-2999(01)00809-3
31. Miyasaka N Hirata Y Nitric oxide and inflammatory arthritides Life Sci 1997, 61:2073-2081 10.1016/S0024-3205(97)00585-7 9395248
32. Ueki Y Miyake S Tominaga Y Eguchi K Increased nitric oxide levels in patients with rheumatoid arthritis J Rheumatol 1996, 23:230-236 8882024
33. St Clair EW Wilkinson WE Lang T Sanders L Misukonis MA Gilkeson GS Pisetsky DS Granger DI Weinberg JB Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients J Exp Med 1996, 184:1173-1178 10.1084/jem.184.3.1173 9064335
34. Becherel PA LeGoff L Frances C Chosidow O Guillosson JJ Debre P Mossalayi MD Arock M Induction of IL-10 synthesis by human keratinocytes through CD23 ligation: A cyclic adenosine 3′,5′-monophosphate-dependent mechanism J Immunol 1997, 159:5761-5765 9550368
35. Miagkov AV Varley AW Munford RS Makarov SS Endogenous regulation of a therapeutic transgene restores homeostasis in arthritic joints J Clin Invest 2002, 109:1223-1229 150962 11994411 10.1172/JCI200214536
36. Shen SC Lee WR Lin HY Huang HC Ko CH Yang LL Chen YC In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production Eur J Pharmacol 2002, 446:187-194 10.1016/ S0014-2999(02)01792-2 12098601
37. O'Leary KA de Pascual-Tereasa S Needs PW Bao YP O'Brien NM Williamson G Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription Mutat Res 2004, 551:245-254 15225597
38. Rot A von Andrian UH Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells Annu Rev Immunol 2004, 22:891-928 10.1146/annurev.immunol.22.012703.104543 15032599
39. Mamani-Matsuda M Kauss T Al-Kharrat A Rambert J Fawaz F Thiolat D Moynet D Coves S Malvy D Mossalayi MD Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators Biochem Pharmacol 2006, 72:1304-1310 10.1016/ j.bcp.2006.08.001 16959220
40. Wadsworth TL McDonald TL Koop DR Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha Biochem Pharmacol 2001, 62:963-974 10.1016/S0006-2952(01)00734-1 11543732
41. Stancovski I Baltimore D NF-kappaB activation: The I kappaB kinase revealed? Cell 1997, 91:299-302 10.1016/S0092-8674(00)80413-4 9363938
42. Garg AK Aggarwal BB Reactive oxygen intermediates in TNF signaling Mol Immunol 2002, 39:509-517 10.1016/S0161-5890(02)00207-9 12431383
43. Kleinert H Pautz A Linker K Schwarz PM Regulation of the expression of inducible nitric oxide synthase Eur J Pharmacol 2004, 500:255-266 10.1016/j.ejphar.2004.07.030 15464038
44. Shoskes DA Zeitlin SI Shahed A Rajfer J Quercetin in men with category III chronic prostatitis: A preliminary prospective, double-blind, placebo-controlled trial Urology 1999, 54:960-963 10.1016/ S0090-4295(99)00358-1 10604689
45. MacLennan WJ Wilson J Rattenhuber V Dikland WJ Vanderdonckt J Moriau M Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: Its efficacy and tolerability Gerontology 1994, 40:45-52 8034203