Hydrophilic fungi and ergosterol associated with respiratory illness in a water-damaged building

Environmental Health Perspectives

Volumn 116, Issue 1, 2008, Pages 45-50

  Park, Ju Hyeong ^a   Cox Ganser, Jean M ^a   Kreiss, Kathleen ^a   White, Sandra K ^a   Rao, Carol Y ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Asthma; Dampness; Endotoxin; Ergosterol; Exposure; Hydrophilic fungi; Office building; Respiratory symptoms; Water damage

Indexed keywords

ALLERGEN; ERGOSTEROL; WATER;

AIR POLLUTANT; ARTICLE; ASTHMA; BACTERIAL COUNT; CASE CONTROL STUDY; DUST; ENVIRONMENTAL MONITORING; FEMALE; FUNGUS; HUMAN; INDOOR AIR POLLUTION; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; MIDDLE AGED; OCCUPATIONAL EXPOSURE;

AIR POLLUTANTS; AIR POLLUTION, INDOOR; ALLERGENS; ASTHMA; CASE-CONTROL STUDIES; COLONY COUNT, MICROBIAL; DUST; ENVIRONMENTAL MONITORING; ERGOSTEROL; FEMALE; FUNGI; HUMANS; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; WATER;

EID: 40949099538     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10355     Document Type: Article

References (35)

1. Burge H. A, Otten JA. 1999. Fungi. In: Bioaerosol: Assessment and Control (Macher J, ed). Cincinnati, OH:American Conference of Governmental Industrial Hygienists, 19-1-19-13.
2. Chao H. J, Milton DK, Schwietz J, Burge HA. 2001. Dustborne fungi in large office buildings. Mycopathologia 154:93-106.
3. Chapman M.D. 1988. Monoclonal antibodies to the major feline allergen Fel d I. II. Single step affinity purification of Fel d I, N-terminal sequence analysis, and development of a sensitive two-site immunoassay to assess Fel d I exposure. J Immunol 140:812-818.
4. Cheong C. D, Neumeister-Kemp HG, Dingle PW, Hardy GD. 2004. Intervention study of airborne fungal spora in homes with portable HEPA filtration units. J Environ Monit 6:866-873.
5. Chun D. T, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson BM, et al. 2002. Second inter-laboratory study comparing endotoxin assay results from cotton dust. Ann Agric Environ Med 9:49-53.
6. Cox-Ganser JM, White S, Jones R, Hilsbos K, Storey E, Enright P. L, et al. 2005. Respiratory morbidity in office workers in a water-damaged building. Environ Health Perspect 113:485-490.
7. Dales R. 1998. Influence of residential fungal contamination on peripheral blood lymphocyte populations in children. Arch Environ Health 53:190-195.
8. Dales R., Miller D, White J. 1999. Testing the association between residential fungus and health using ergosterol measures and cough recordings. Mycopathologia 147:21-27.
9. Day J. H, Ellis AK. 2001. Allergenic microorganisms and hypersensitivity. In: Microorganisms in Home and Indoor Work Environments: Diversity, Health Impacts, Investigation and Control (Flannigan B, Samson RA, Miller JD, eds). New York:Taylor and Francis, 103-127.
10. de Groot H. 1991. Affinity purification of a major and a minor allergen from dog extract: serologic activity of affinitypurified Can f I and of Can f I-depleted extract. J Allergy Clin Immun 87:1056-1065.
11. Dharmage S., Bailey M, Raven J, Abeyawickrama K, Cao D, Guest D., et al. 2002. Mouldy houses influence symptoms of asthma among atopic individuals. Clin Exp Allergy 32:714-720.
12. Dharmage S., Bailey M, Raven J, Mitakakis T, Cheng A, Guest D., et al. 2001. Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure. Am J Respir Crit Care Med 164:65-71.
13. Ebbehoj N. E, Meyer HW, Wurtz H, Suadicani P, Valbjorn O, Sigsgaard T., et al. 2005. Molds in floor dust, building-related symptoms, and lung function among male and female schoolteachers. Indoor Air 15:7-16.
14. Flannigan B., McCabe EM, Jupe SV, Jeffrey IG. 1993. Mycological and acaralogical investigation of complaint and non-complaint houses in Scotland. In: Indoor Air '93, Proceedings of the Sixth International Conference on Indoor Air and Climate, Vol 4. Helsinki, Finland:Indoor Air '93, 143-148.
15. Flannigan B., Miller JD. 2001. Microbial growth in indoor environments. In: Microorganisms in Home and Indoor Work Environments: Diversity, Health Impacts, Investigation and Control (Flannigan B, Samson RA, Miller JD, eds). New York:Taylor and Francis, 35-67.
16. Grant C., Hunter CA, Flannigan B, Bravery AF. 1989. The moisture requirements of moulds isolated from domestic dwellings. Int Biodeter 25:259-284.
17. Hicks J. B, Lu ET, De Guzman R, Weingart M. 2005. Fungal types and concentrations from settled dust in normal residences. J Occup Environ Hyg 2:481-492.
18. Hodges G. R, Fink JN, Schlueter DP. 1974. Hypersensitivity pneumonitis caused by a contaminated cool-mist vaporizer. Ann Intern Med 80:801-804.
19. Horner W.E. 2004. Air-and dustborne mycoflora in houses free of water damage and fungal growth. Appl Environ Microbiol 70:6394-6400.
20. Hornung R. W, Reed L. 1990. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hygiene 5:46-51.
21. Institute of Medicine. 2004. Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC:National Academies Press, 183-269.
22. Matheson M. C, Abramson MJ, Dharmage SC, Forbes AB, Raven J. M, Thien FCK, et al. 2005. Changes in indoor allergen and fungal levels predict changes in asthma activity among young adults. Clin Exp Allergy 35:907-913.
23. Mendell M. J, Fisk WJ, Petersen MR, Hines CJ, Dong M, Faulkner D., et al. 2002. Indoor particles and symptoms among office workers: results from a double-blind crossover study. Epidemiology 13:296-304.
24. Menzies D., Kreiss K. 2006. Building-related illnesses. In: Asthma in the Workplace (Bernstein L, Chan-Yeung M, Malo J-L, Bernstein D, eds). New York:Taylor & Francis, 737-783.
25. Miller J.D. 2001. Mycological investigations of indoor environments. In: Microorganisms in Home and Indoor Work Environments: Diversity, Health Impacts, Investigation and Control (Flannigan B, Samson RA, Miller JD, eds). New York:Taylor and Francis, 231-246.
26. Newell S.Y. 1994. Total and free ergosterol in mycelia of saltmarsh Ascomycetes with access to whole leaves or aqueous extracts of leaves. Appl Environ Microbiol 60:3479-3482.
27. Nielsen K. F, Madsen JO. 2000. Determination of ergosterol on mouldy building materials using isotope dilution and gas chromatography-tandem mass spectrometry. J Chromatogr A 898:227-234.
28. Park J. H, Cox-Ganser J, Rao C, Kreiss K. 2006. Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building. Indoor Air 16:192-203.
29. Pasanen A. L, Yli-Pietila K, Pasanen P, Kalliokoski P, Tarhanen J. 1999. Ergosterol content in various fungal species and biocontaminated building materials. Appl Environ Microbiol 138-142.
30. Rantio-Lehtimaki A. 1988. Yeasts in rural and urban air in southern Finland. Grana 27:313-319.
31. Saraf A., Larsson L, Burge H, Milton D. 1997. Quantification of ergosterol and 3-hydroxy fatty acids in settled house dust by gas chromatography-mass spectrometry: comparison with fungal culture and determination of endotoxin by a Limulus amebocyte lysate assay. Appl Environ Microbiol 63:2554-2559.
32. Sebastian A., Larsson L. 2003. Characterization of the microbial community in indoor environments: a chemical-analytical approach. Appl Environ Microbiol 69:3103-3109.
33. Siersted H. C, Gravesen S. 1993. Extrinsic allergic alveolitis after exposure to the yeast Rhodotorula rubra. Allergy 48:298-299.
34. Szponar B., Larsson L. 2000. Determination of microbial colonization in water-damaged building using chemical marker analysis by gas chromatography-mass spectrometry. Indoor Air 10:13-18.
35. Verhoeff A. P, van Wijnen JH, van Reenen-Hoekstra ES, Samson R. A, van Strien RT, Brunekreef B. 1994. Fungal propagules in house dust. II. Relation with residential characteristics and respiratory symptoms. Allergy 49:540-547.