Association of SNPs in the proximal promoter region of the APM1 gene with obesity and type 2 diabetes

Journal of Xi'an Jiaotong University (Medical Sciences)

Volumn 29, Issue 1, 2008, Pages

  Ye, Feng ^a   He, Lan ^a   Li, Jianning ^a   Dong, Chunping ^a   Yu, Jie ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Adiponectin; Diabetes mellitus; Gene polymorphism; Obesity

Indexed keywords

ADIPONECTIN;

ARTICLE; BODY MASS; DIASTOLIC BLOOD PRESSURE; GENE MUTATION; GENETIC RISK; GENOTYPE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POLYMERASE CHAIN REACTION; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

EID: 40849141118     PISSN: 16718259     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity [J]. Obesity Reviews, 2005, 6(1):13-21.
2. Gu HF, Abulaiti A, Ostenson CG, et al. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians [J]. Diabetes, 2004, 53 (Suppl. 1 ):S31-S35.
3. Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome [J]. Clin Invest, 2006, 116(7):1784-1792.
4. Gibson F, Froguel P. Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians [J]. Diabetes, 2004, 53(11):2977-2983.
5. Populaire C, Mori Y, Dina C, et al. Does the 11377 promoter variant of APM1 gene contribute to the genetic risk for type 2 diabetes mellitus in Japanese families [J]? Diabetologia, 2003, 46(3): 443-445.
6. Vasseur F, Helbecque N, Dina C, et al. Single-nucleotide polymorphism haplotypes in the both proximal Promoter and exon3 of the APM1 gene modulate adipocyte-secreted adiponectin Hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians [J]. Human Molecular Genetics, 2002, 11(21):2607-2614.
7. Permutt M, Wasson J, Cox N, et al. Genetic epidemiology of diabetes [J]. Clin Invest, 2005, 115(6):1431-1439.