NMR based structure-activity relationship analysis of an antimicrobial peptide, thanatin, engineered by site-specific chemical modification: Activity improvement and spectrum alteration

Biochemical and Biophysical Research Communications

Volumn 369, Issue 2, 2008, Pages 609-615

  Imamura, Tomohiro ^a   Yamamoto, Naoki ^b   Tamura, Atsuo ^b   Murabayashi, Shinji ^c   Hashimoto, Shigeki ^a   Shimada, Hiroaki ^a   Taguchi, Seiichi ^c  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Activity spectrum; Antimicrobial peptide; Disulfide bridge; NMR solution structure; Site specific chemical modification; Thanatin

Indexed keywords

CYSTEINE; DISULFIDE; POLYPEPTIDE ANTIBIOTIC AGENT; THANATIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL ENGINEERING; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISULFIDE BOND; DRUG SPECIFICITY; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROPHOBICITY; MICROCOCCUS LUTEUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL PHYSIOLOGY; CELL SURVIVAL; COMPUTER SIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; MICROCOCCUS LUTEUS; NEGIBACTERIA; POSIBACTERIA;

EID: 40849133839     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.057     Document Type: Article

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