Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

Aging Clinical and Experimental Research

Volumn 20, Issue 1, 2008, Pages 8-14

  Milman, Nils ^a,c   Pedersen, Agnes N ^a,b   Ovesen, Lars ^b   Schroll, Marianne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c NONE   (Denmark)

Author keywords

Aged; Anemia; Hemoglobins; Muscle strength; Physical endurance; Reference interval

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; HEMOGLOBIN; IRON;

AGED; ANEMIA; ARTICLE; BLOOD SAMPLING; DIET; ERYTHROCYTE; FEMALE; FERRITIN BLOOD LEVEL; FOOD INTAKE; HUMAN; IRON INTAKE; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MEAT; MUSCLE STRENGTH; PHYSICAL PERFORMANCE; WORLD HEALTH ORGANIZATION;

EID: 40849131180     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324741     Document Type: Article

References (29)

1. Milman N. Serum ferritin in Danes: Studies of iron status from infancy to old age, during blood donation and pregnancy. Int J Hematol 1996; 63: 103-35.
2. Nilsson-Ehle H, Jagenburg R, Landahl S, Svanborg A, Westin J. Decline of blood hemoglobin in the aged. A longitudinal study of an urban Swedish population sample. Br J Haematol 1989; 71: 437-42.
3. Nielsson-Ehle H, Jagenburg R, Landahl S, Svanborg A. Blood hemoglobin declines in the elderly. Implications for reference intervals from age 70 to 88. Eur J Haematol 2000; 65: 297-305.
4. Skjelbakken T, Langbakk B, Dahl IMS, Løchen M-L. Hemoglobin and anemia in a gender perspective. Eur J Haematol 2005; 74: 381-8.
5. Milman N, Ovesen L, Byg K-E, Graudal N. Iron status in Danes updated 1994. I: Prevalence of iron deficiency and iron overload in 1332 men aged 40-70 years. Influence of blood donation, alcohol intake, and iron supplementation. Ann Hematol 1999; 78: 393-400.
6. Milman N, Ovesen L, Byg K-E, Graudal N. Iron status in Danes 1994. II: Prevalence of iron deficiency and iron overload in 1319 Danish women aged 40-70 years. Influence of blood donation, alcohol intake, and iron supplementation. Ann Hematol 2000; 79: 612-21.
7. Salive ME, Cornoni-Huntley J, Guralnik JM, et al. Anemia and hemoglobin levels in older persons: relationship with age, gender, and health status. J Am Geriatr Soc 1992; 40: 489-96.
8. Chaves PH, Xue QL, Guralnik JM, Ferrucci L, Volpato S, Fried LP. What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc 2004; 52: 1811-6.
9. Chaves PHM, Ashar B, Guralnik JM, Fried LP. Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated? J Am Geriatr Soc 2002; 50: 1257-64.
10. Chaves PH, Semba RD, Leng SX, et al. Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging Studies I and II. J Gerontol Biol Sci Med Sci 2005; 60: 729-35.
11. Milman N, Pedersen AN, Ovesen L, Schroll M. Iron status in 358 apparently healthy men and women. Relation to food composition and dietary and supplemental iron intake. Ann Hematol 2004; 83: 423-9.
12. Pedersen AN. Nutritional status of 80-year-old Danish men and women - and the relation to functional ability [80-åriges ernæringsstatus - og relationen til fysisk funktionsevne. 80-års undersøgelsen 1994/95.] Ph.d-thesis 2001. University of Copenhagen. (In Danish, abstract in English).
13. Milman N, Juul-Jørgensen B, Bentzon MW. Calibration of Abbott AxSYM® Ferritin kit using the WHO Human Liver Ferritin International Standard 80/602. Eur J Clin Chem Clin Biochem 1997; 35: 631-2.
14. Cook JD, Skikne B. Iron deficiency: definition and diagnosis. J Intern Med 1989; 226: 349-55.
15. Milman N, Pedersen NS, Visfeldt J. Serum ferritin in healthy Danes: relation to marrow haemosiderin iron stores. Dan Med Bull 1983; 30: 115-20.
16. World Health Organization. Nutritional Anemias. Tech Rep Ser 1972, no. 503.
17. Reuben DB, Siu AL. An objective measure of physical function of elderly outpatients. The physical performance test. J Am Geriatr Soc 1990; 38: 1105-12.
18. Rantanen T. Maximal isometric strength in older adults. Thesis. University of Jyväskylä. Studies in sport, physical education and health 32. 1994.
19. Viitasalo J, Komi P, Karvonen M. Physical health and performance ability, and physical activity habits in conscripts in the beginning of service at Air Force Communications School. Research Reports from the Biology of Physical Activity, University of Jyväskylä. 1977.
20. Saxholt E. Food composition tables. Food Agency of Denmark. 4th ed. 1996.
21. Ligthart GJ, Corberand JX, Fournier C, et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev 1984; 28: 47-55.
22. Milman N, Byg K-E, Mulvad G, Pedersen HS, Bjerregaard P. Hemoglobin concentrations appear to be lower in indigenous Greenlanders than in Danes: assessment of hemoglobin in 234 Greenlanders and 2804 Danes. Eur J Haematol 2001; 67: 23-9.
23. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011-23.
24. Skikne R, Baynes RD. Iron absorption. In Brock JH, Halliday JW, Pippard MJ, Powell LW, eds. Iron Metabolism in Health and Disease. London: Saunders, 1994: 151-87.
25. Maruyama S, Yamoto S, Koda M, et al. Red blood cell status in alcoholic and non-alcoholic liver disease. J Lab Clin Med 2001; 138: 332-7.
26. Penninx BW, Pahor M, Cesari M, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc 2004; 52: 719-24.
27. Izaks GJ, Westendorp RGJ, Knook DL. The definition of anemia in older persons. J Am Med Assoc 1999; 281: 1714-7.
28. Edgerton VR, Ohira Y, Hettiarachchi J, Senewiratne B, Gardner GW, Barnard RJ. Elevation of hemoglobin and work tolerance in iron-deficient subjects. J Nutr Sci Vitaminol (Tokyo) 1981; 27: 77-86.
29. Mercer KW, Densmore JJ. Hematologic disorders in the athlete. Clin Sports Med 2005; 24: 599-621.