Initiation of apoptosis by photodynamic therapy using a novel positively charged and water-soluble near infra-red photosensitizer and white light irradiation

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 30, Issue 1, 2008, Pages 17-23

  Schastak, Stanislaw ^a   Yafai, Y ^a   Geyer, W ^b   Kostenich, G ^c   Orenstein, A ^c   Wiedemann, P ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

BALB c mice tumor model; Choroidal melanoma cell; Photodynamic therapy; Photosensitizer

Indexed keywords

CASPASE 8; EVANS BLUE; PHOTOSENSITIZING AGENT; TETRAHYDROPORPHYRIN TETRATOSYLAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CHOROID MELANOMA; COLON CARCINOMA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PURITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE; HUMAN; HUMAN CELL; IRRADIATION; MELANOMA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PROTON NUCLEAR MAGNETIC RESONANCE; STAINING; WHITE LIGHT IRRADIATION;

ANIMALS; APOPTOSIS; CASPASE 8; CELLS, CULTURED; COLONIC NEOPLASMS; LIGHT; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; TRANSPLANTATION, HETEROLOGOUS;

EID: 40849124093     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2008.30.1.1134340     Document Type: Article

References (19)

1. MacDonald, I.J., Dougherty, T.J. Basic principles of photodynamic therapy. J Porphyr Phthalocyanine 2001, 5: 105-29.
2. Hopper, C., Kubier, A., Lewis, H., Tan, I.B., Putnam, G. mTHPC-Mediated photodynamic therapy for early oral squamous cell carcinoma. Int J Cancer 2004, 111(1): 138-46.
3. Prosst, R.L., Wolfsen, H.C., Gahlen, J. Photodynamic therapy for esophageal diseases: A clinical update. Endoscopy 2003, 35: 1059-68.
4. Messmer, K.J., Abel, S.R. Verteporfin for age-related macular degeneration. Ann Pharmacother 2001, 35: 1593-8.
5. Jori, G., Fabris, C., Soncin, M., et al. Photodynamic therapy in the treatment of microbial infections: Basic principles and perspective applications. Lasers Surg Med 2006, 38(5): 468-81.
6. Funke, B., Jungel, A., Schastak, S., et al. Transdermal photodynamic therapy - A treatment option for rheumatic destruction of small joints? Lasers Surg Med 2006, 38(9): 866-74.
7. Castano, A.P., Demidova, T.N., Hamblin, M.R. Mechanisms in photodynamic therapy, Part 1: Photosensitizers, photochemistry and cellular localization. Photodiagn Photodyn Ther 2004, 1: 279-93.
8. Castano, A.P., Demidova, T.N., Hamblin, M.R. Mechanisms in photodynamic therapy. Part 2: Cellular signaling, cell metabolism and modes of cell death. Photodiagn Photodyn Ther 2005, 2: 1-23.
9. Castano, A.P., Demidova, T.N., Hamblin, M.R. Mechanisms in photodynamic therapy, Part 3: Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. Photodiagn Photodyn Ther 2005, 2: 91-106.
10. Chen, B., Roskams, T., Xu, Y., et al. Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model. Int J Cancer 2002, 98(2): 284-90.
11. Kaneko, T., Chiba, H., Yasuda, T., Kusama, K. Detection of photodynamic therapy-induced early apoptosis in human salivary gland tumor cells in vitro and in a mouse tumor model. Oral Oncol 2004, 40: 787-92.
12. Noodt, B.B., Berg, K., Stokke, T., Peng, Q., Nesland, J.M. Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light. Br J Cancer 1999, 79: 72-81.
13. Susin, S.A., Zamzami, N., Kroemer, G. Mitochondria as regulators of apoptosis. Biochim Biophys Acta 1998, 1366: 151-65.
14. Schastak, S., Jean, B., Handzel, R., Kostenich G., et al. Improved pharmacokinetics, biodistribution and necrosis in vivo using a new near infra-red photosensitizer: Tetrahydroporphyrin tetratosylat. J Photochem Photobiol B 2005, 78(3): 203-13.
15. Hamblin, M.R., Hasan, T. Photodynamic therapy: A new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004, 3(5): 436-50.
16. Dupouy, E.A., Lazzeri, D., Duranti, E.N. Photodynamic activity of cationic and non-charged Zn(II) tetrapyridinoporphyrazine derivatives: Biological consequences in human erythrocytes and Escherichia coli. Photochem Photobiol Sci 2004, 3(11-12): 992-8.
17. Milanesio, M.E., Alvarez, M.G., Silber, J.J., et al. Photodynamic activity of monocationic and non-charged methoxyphenylporphyrin derivatives in homogeneous and biological media. Photochem Photobiol Sci 2003; 2: 926-33.
18. Caminos, D.A., Spesia, M.B., Durantini, E.N. Photodynamic inactivation of Escherichia coli by novel meso-substituted porphyrins by 4-(3-N,N,N-trimethylammoniumpropoxy)phenyl and 4-(trifluoromethyl)phenyl groups. Photochem Photobiol Sci 2006, 5: 56-65.
19. Oertel, M., Schastak, S.I., Tannapfel, A., et al. Novel bacteriochlorine for high tissue-penetration: Photodynamic properties in human biliary tract cancer cells in vitro and in a mouse tumour model. J Photochem Photobiol B 2003, 71: 1-10.