The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: Analysis of brain area epibatidine binding and cotinine levels

Pharmacology Biochemistry and Behavior

Volumn 89, Issue 3, 2008, Pages 424-431

  Pehrson, Alan L ^a   Philibin, Scott D ^a   Gross, Daniel ^a   Robinson, Susan E ^a   Vann, Robert E ^a   Rosecrans, John A ^a   James, John R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Baseline activity; Behavioral sensitization; Brain area nAChR binding; Nicotine

Indexed keywords

COTININE; EPIBATIDINE; NICOTINE TARTRATE; NICOTINIC RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; FEMALE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE; THALAMUS;

ANIMALS; BEHAVIOR, ANIMAL; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; COTININE; FEMALE; MALE; MOTOR ACTIVITY; NICOTINE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS;

ANIMALIA; RATTUS;

EID: 40849107719     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.01.018     Document Type: Article

References (23)

1. Alzoubi K.H., Aleisa A.M., and Alkadhi K.A. Adult-onset hypothyroidism facilitates and enhances LTD: reversal by chronic nicotine treatment. Neurobiol Dis 26 (2007) 264-272
2. Alzoubi K.H., Aleisa A.M., and Alkadhi K.A. Nicotine prevents disruption of the late phase LTP-related molecular cascade in adult-onset hypothyroidism. Hippocampus 17 (2007) 654-664
3. Booze R.M., Welch M.A., Wood M.L., Billings K.A., Apple S.R., and Mactutus C.F. Behavioral sensitization following repeated intravenous nicotine administration: gender differences and gonadal hormones. Pharmacol Biochem Behav 64 4 (1999) 827-839
4. Gentry C.L., Wilkins Jr. L.H., and Lukas R.J. Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human a4b2-and a4b4-nicotinic acetylcholine receptors. J Pharmacol Exp Ther 304 1 (2003) 206-216
5. Ghosheh O., Dwoskin L.P., Li W.K., and Crooks P.A. Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine. Drug Metab Dispos 27 12 (1999) 1448-1455
6. Harrod S.B., Mactutus C.F., Bennett K., Hasselrot U., Wu G., Welch M., and Booze R.M. Sex differences and repeated intravenous nicotine: behavioral sensitization and dopamine receptors. Pharmacol Biochem Behav 78 3 (2004) 581-592
7. Hendry J.S., and Rosecrans J.A. Effects of nicotine on conditioned and unconditioned behaviors in experimental animals. Pharmacol Ther 17 3 (1982) 431-454
8. Houghtling R.A., Davila-Garcia M.I., and Kellar K.J. Characterization of (+/-)(-)[3H]epibatadine binding to nicotinic cholinergic receptors in rat and human brain. Mol Pharmacol 48 2 (1995) 280-287
9. James J.R., Villanueva H.F., Johnson J.H., Arezo S., and Rosecrans J.A. Evidence that nicotine can acutely desensitize central nicotinic acetylcholinergic receptors. Psychopharmacology 114 (1994) 456-462
10. Johnson J.H., Zhao C., James J.R., and Rosecrans J.A. Individual variability of dopamine release from nucleus accumbens induced by nicotine. Brain Res Bull 51 3 (2000) 249-253
11. Kuo D.Y., Lin T.B., Huang C.C., Duh S.L., Liao J.M., and Cheng J.T. Nicotine-induced hyperlocomotion is not modified by the estrous cycle, ovariectomy and estradiol replacement at physiological level. Chin J Physiol 42 2 (1999) 83-88
12. Marks M.J., and Collins A.C. Tolerance, cross-tolerance, and receptors after chronic nicotine or oxotremorine. Pharmacol Biochem Behav 22 2 (1985) 283-291
13. Robinson J.H., and Pritchard W.S. The role of nicotine in tobacco use. Psychopharmacology 113 2 (1992) 282-283
14. Robinson S.E., James J.R., Lapp L.N., Vann R.E., Gross D.F., Philibin S.D., and Rosecrans J.A. Evidence of cellular nicotinic receptor desensitization in rats exhibiting nicotine-induced acute behavioral tolerance. Psychopharmacology 184 3-4 (2006) 306-313
15. Robinson S.E., Vann R.E., Britton A.F., O'Connell M., James J.R., and Rosecrans J.A. Cellular nicotinic receptor desensitization correlates with nicotine-induced acute behavioral tolerance in rats. Psychopharmacology 192 1 (2007) 71-78
16. Robinson T.E., and Berridge K.C. Incentive-sensitization and addiction. Addiction 96 (2001) 103-114
17. Rosecrans J.A. Brain area nicotine levels in male and female rats with different levels of spontaneous activity. Neuropharmacology 11 6 (1972) 863-870
18. Rosecrans J.A. The psychopharmacological basis of nicotine's differential effects on behavior: individual subject variability in the rat. Behav Genet 25 2 (1995) 187-196
19. Rosecrans J.A., Wiley J.L., Bass C.E., and Karan L.D. Nicotine induced acute tolerance: studies involving schedule-controlled Behavior. Brain Res Bull 37 4 (1995) 359-362
20. Rowell P.P., Carr L.A., and Garner A.C. Stimulation of [3H]dopamine release by nicotine in rat nucleus accumbens. J Neurochem 49 5 (1987) 1449-1454
21. Rowell P.P., and Li M. Dose-response relationship for nicotine-induced up-regulation of rat brain nicotinic receptors. J Neurochem 68 (1997) 1982-1989
22. Schwartz R.D., and Kellar K.J. In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J Neurochem 45 2 (1985) 427-433
23. Wilcoxon J.S., Nadolski G.J., Samarut J., Chassande O., and Redei E.E. Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha. Behav Brain Res 177 (2007) 109-116