In vitro anti-Gram-positive and antistaphylococcal biofilm activity of newly halogenated pyrroles related to pyrrolomycins

International Journal of Antimicrobial Agents

Volumn 31, Issue 4, 2008, Pages 380-382

  Schillaci, D ^a   Petruso, S ^a   Cascioferro, S ^a   Raimondi, M V ^a   Haagensen, J A J ^b   Molin, S ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3,4,5,3',5' PENTABROMO 2 (2' HYDROXYBENZOYL)PYRROLE; ANTIINFECTIVE AGENT; ORGANOHALOGEN DERIVATIVE; PYRROLE DERIVATIVE; PYRROLOMYCIN D; UNCLASSIFIED DRUG; VANCOMYCIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; BACTERIAL STRAIN; BIOFILM; COAGULASE NEGATIVE STAPHYLOCOCCUS; DEVICE INFECTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LETTER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-BACTERIAL AGENTS; BIOFILMS; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PYRROLES; STAPHYLOCOCCUS; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN;

EID: 40849096318     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.10.013     Document Type: Letter

References (6)

1. Götz F. Staphylococcus and biofilms. Mol Microbiol 43 (2002) 1367-1378
2. Projan S.J., and Youngman P.J. Antimicrobials: new solutions badly needed. Curr Opin Microbiol 5 (2002) 463-465
3. Gribble G.W. The diversity of naturally produced organohalogens. Chemosphere 52 (2003) 289-297
4. Schillaci D., Petruso S., and Sciortino V. 3,4,5,3′5′-Pentabromo-2-(2′-hydroxybenzoyl) pyrrole: a potential lead compound as anti-Gram-positive and anti-biofilm agent. Int J Antimicrob Agents 25 (2005) 338-340
5. Zhang X., and Parry R.J. Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. UC 11065. Antimicrob Agents Chemother 51 (2006) 946-957
6. Raimondi M.V., Schillaci D., and Petruso S. Synthesis and anti-staphylococcal activity of new halogenated pyrroles related to pyrrolomycin F. J Heterocyclic Chem 44 (2007) 1407-1411