Troponin: Regulatory function and disorders

Biochemical and Biophysical Research Communications

Volumn 369, Issue 1, 2008, Pages 62-73

  Ohtsuki, Iwao ^a   Morimoto, Sachio ^b  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Calcium ion; Dilated cardiomyopathy; Hypertrophic cardiomyopathy; Muscle contraction; Restrictive cardiomyopathy; Troponin; Troponin C; Troponin I; Troponin T

Indexed keywords

CALCIUM ION; MYOSIN ADENOSINE TRIPHOSPHATASE; TROPOMYOSIN; TROPONIN; TROPONIN C; TROPONIN I; TROPONIN T;

CALCIUM BINDING; CALCIUM SIGNALING; CARDIOMYOPATHY; COMPLEX FORMATION; CONGESTIVE CARDIOMYOPATHY; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MOLECULAR DYNAMICS; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESTRICTIVE CARDIOMYOPATHY; REVIEW; THIN FILAMENT;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CARDIOMYOPATHIES; HEART; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; TROPONIN;

EID: 40849094355     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.11.187     Document Type: Review

References (73)

1. Ebashi S. Third component participating in the superprecipitation of natural actomyosin. Nature (London) 200 (1963) 1010
2. Ebashi S., and Ebashi F. A new protein component participating in the superprecipitation of myosin B. J. Biochem. 55 (1964) 604-613
3. Bailey K. Tropomyosin: a new asymmetric protein component of muscle. Nature (London) 157 (1946) 368-369
4. Bailey K. Tropomyosin: a new asymmetric protein component of the muscle fibril. Biochem. J. 43 (1948) 71-279
5. Ebashi S., and Kodama A. A new protein factor promoting aggregation of tropomyosin. J. Biochem. 58 (1965) 107-108
6. Ebashi S., Kodama A., and Ebashi F. Troponin 1. Preparation and physiological function. J. Biochem. 64 (1968) 465-477
7. Ohtsuki I., Masaki T., Nonomura Y., and Ebashi S. Periodic distribution of troponin along thin filament. J. Biochem. 81 (1967) 817-819
8. Ebashi S., Endo M., and Ohtsuki I. Control of muscle contraction. Q. Rev. Biophys. 2 (1969) 351-384
9. Hartshorne D.J., and Mueller H. Fractionation of troponin into two distinct proteins. Biochem. Biophys. Res. Commun. 31 (1968) 647-653
10. Schaub M.C., and Perry S.V. The relaxing protein system of striated muscle. Biochem. J. 1155 (1969) 903-1004
11. Greaser M.L., and Gergely J. Reconstitution of troponin activity from three protein components. J. Biol. Chem. 246 (1971) 4226-4233
12. Ebashi S. Troponin and its components. J. Biochem. 72 (1972) 87-790
13. Ohtsuki I., Maruyama K., and Ebashi S. Regulatory and cytoskeletal proteins of vertebrate skeletal muscle. Adv. Prot. Chem. 38 (1986) 1-68
14. Fatkin D., and Graham R.M. Molecular mechanism of inherited cardiomyopathies. Physiol. Rev. 82 (2002) 945-980
15. Ahmad F., Seidman J.G., and Seidman C.E. The genetic basis for cardiac remodeling. Annu. Rev. Genomics Hum. Genet. 6 (2005) 85-216
16. Ohtsuki I. Troponin: structure, function and dysfunction. Adv. Exp. Med. Biol. 565 (2007) 21-36
17. Tsao T.-C., Bailey K., and Adair G.S. The size, shape and aggregation of tropomyosin particles. J. Biochem. 49 (1951) 27-36
18. Ooi T., Mihashi K., and Kobayashi H. On the polymerization of tropomyosin. Arch. Biochem. Biophys. 98 (1962) 1-11
19. Ohtsuki I. Localization of troponin in thin filament and tropomyosin paracrystal. J. Biochem. 75 (1974) 753-765
20. Ebashi S. Regulatory mechanism of muscle contraction with special reference to the Ca-troponin-tropomyosin system. Essays in Biochem. 10 (1974)
21. Ohtsuki I. Distribution of troponin components in the thin filament studied by immunoelectron microscopy. J. Biochem. 77 (1975) 633-639
22. Ohtsuki I. Molecular arrangement of troponin T in thin filament. J. Biochem. 86 (1979) 491-497
23. Pearlstone J.R., Carpenter M.R., Johnson P., and Smillie L.B. Amino-acid sequence of tropomyosin binding component of rabbit skeletal muscle troponin. Proc. Natl. Acad. Sci. USA 73 (1976) 1902-1906
24. Tanokura M., Tawada Y., and Ohtsuki I. Chymotryptic subfragments of troponin T from rabbit skeletal muscle. I. Determination of the primary structure. J. Biochem. 91 (1982) 1257-1265
25. Tanokura M., Tawada Y., Ono A., and Ohtsuki I. Chymotryptic subfragments of troponin T from rabbit skeletal muscle. Interaction with tropomyosin, troponin I and troponin C. J. Biochem. 93 (1983) 331-337
26. Jackson P., Amphlett G.W., and Perry S.V. The primary structure of troponin T and the interaction with tropomyosin. Biochem. J. 151 (1975) 85-97
27. Ohtsuki I., Shiraishi F., Suenaga N., Miyata T., and Tanokura M. 26 K fragment of troponin T from rabbit skeletal muscle. J. Biochem. 95 (1984) 1337-1342
28. 2 -terminal residues of rabbit skeletal troponin T strengthens binding of troponin to immobilized tropomyosin. J. Biol. Chem. 266 (1991) 12432-12438
29. Shiraishi F., Kambara M., and Ohtsuki I. Replacement of troponin in myofibrils. J. Biochem. 111 (1992) 61-65
30. 2+-saturated form. Nature 424 (2003) 35-41
31. 2+-regulated structural changes in troponin. Proc. Natl. Acad. Sci. USA 102 (2005) 5038-5043
32. Perry S.V. Troponin I: inhibitor or facilitator. Mol. Cell. Biochem. 190 (1999) 9-32
33. Ohtsuki I., and Shiraishi F. Periodic binding of troponin C·I and troponin I to tropomyosin-actin filaments. J. Biochem. 131 (2002) 739-743
34. Ohtsuki I., Onoyama Y., and Shiraishi F. Electron microscopic study of troponin. J. Biochem. 103 (1988) 913-919
35. Nagano K., and Ohtsuki I. Prediction of approximate quaternary structure of troponin complex. Proc. Japan Acad. 58 (1982) 73-77 Ser.B
36. 2+-activated tension development of single glycerinated rabbit skeletal muscle fibers. Eur. J. Biochem. 205 (1992) 985-993
37. Ojima T., and Nishita K. Troponin from Akazara scallop striated adductor muscle. J. Biol. Chem. 261 (1986) 16749-16754
38. 2+-sensitive ATPase activity of myofibrils from scallop striated muscle. J. Biochem. 126 (1999) 1020-1024
39. 2- or COOH-terminal region of molluskan and vertebrate troponin-I. FEBS J. 272 (2005) 4475-4486
40. Thierfelder L., Watkins H., MacRae C., Lamas R., McKenna W.J., Vosberg H.P., Seidman J.G., and Seidman C.E. α-Tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy. Cell 77 (1994) 701-712
41. 2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy. Am. J. Physiol. 275 (1998) C200-C207
42. Nakaura H., Morimoto S., Yanaga F., Nakata M., Nishi N., Imaizumi Y., and Ohtsuki I. Functional changes in troponin T by a splice donor site mutation that causes hypertrophic crdiomyopathy. Am. J. Physiol. 277 (1999) C225-C232
43. Morimoto S., Nakaura H., Yanaga F., and Ohtsuki I. Functional consequences of a carboxy terminal missense mutation Arg278Cys in human cardiac troponin T. Biochem. Biophys. Res. Commun. 261 (1999) 79-82
44. Nakaura H., Yanaga F., Ohatsuki I., and Morimoto S. Effects of missense mutations Phe110I and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers. J. Biochem. 126 (1999) 457-460
45. Szczesna D., Zhang R., Zhao J., Jones M., Guzman G., and Potter J.D. Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy. J. Biol. Chem. 275 (2000) 624-630
46. 2+ desensitizing effect of a deletion mutation delta-K210 in cardiac troponin T that causes familial dilated cardiomyopathy. Proc. Natl. Acad. Sci. USA 99 (2002) 913-918
47. 2+ desensitization. J. Mol. Cell. Cardiol. 35 (2003) 1421-1427
48. Venkatraman G., Harada K., Gomes A.V., Kerrick W.G., and Potter J.D. Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J. Biol. Chem. 278 (2003) 41670-41676
49. 2+-sensitivity of cardiac muscle contraction. J. Biol. Chem. 279 (2004) 14488-14495
50. Kamisago M., Sharma S.D., DePelma S.R., Solomon S., Sharma P., McDonough B., Smool L., Mullen M.P., Woolf P.K., Wigle E.D., and Seidman C.E. Mutations in sarcomere protein genes as a cause of dilated Cardiomyopathy. N. Engl. J. Med. 343 (2000) 1688-1696
51. Mirza M., Marston S., Willott R., Ashley C., Mogensen J., McKenna W., Robinson P., Redwood C., and Watkins H. Dilated cardiomyopathy mutations in three thin filament regulatory proteins results in a common functional phenotype. J. Biol. Chem. 280 (2005) 28498-28506
52. Sumandea M.P., Pyles W.G., Kobayashi T., de Tombe P.P., and Solaro R.J. Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J. Biol. Chem. 278 (2003) 35135-35144
53. Oliveira D.M., Nakaie C.R., Sousa A.D., Farah C.S., and Reinach C. Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity. Identification of residues involved in binding to actin. J. Biol. Chem. 275 (2000) 27513-27519
54. Kimura A., Hara H., Park J.E., Nishi H., Satoh M., Takahashi M., Hiroi S., Sasaoka T., Ohbuchi N., Nakamura T., Koyanagi T., Hwang T.H., Choo J.A., Chung K.S., Hasegawa A., Nagai R., Okazaki O., Nakamura H., Matsuzaki M., Sakamoto T., Toshima H., Koga Y., Imaizumi Y., and Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat. Genet. 16 (1997) 379-382
55. Takahashi-Yanaga F., Morimoto S., Harada K., Minakami R., Shiraishi F., Ohta M., Lu Q.-W., Sasaguri T., and Ohtsuki I. Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy. J. Mol. Cell. Cardiol. 33 (2001) 2095-2107
56. 2+-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin. J. Mol. Cell. Cardiol. 39 (2005) 754-765
57. Mogensen J., Kubo T., Duque M., Uribe W., Shaw A., Murphy R., Gimeno J.R., Elliott P., and Mckenna W.J. Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations. J. Clin. Invest. 111 (2003) 209-216
58. 2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy. Biochem. Biophys. Res. Commun. 338 (2005) 1519-1526
59. Gomes A.V., Liang J., and Potter J.D. Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol. Chem. 280 (2005) 30909-30915
60. Kobayashi T., and Solaro R.J. Increased affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin T. J. Biol. Chem. 281 (2006) 13471-13477
61. Hoffman B., Schmidt-Traub H., Perrot A., Osterziel K.J., and Gessner R. First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy. Hum. Mutat. 17 (2001) 524
62. Preston L., Lipscomb S., Robinson P., Watkins H., Redwood C., Mogensen J., and Ashley C. Mechanical effect of human cardiac troponin C mutation Gly159Asp in exchanged rabbit psoas fibers. Biophys. J. 86 (2004) 396a
63. Biesiadecki B.J., Kobayashi T., Walker J.S., Solaro R.J., and deTombe P.P. The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ. Res. 100 (2007) 1486-1493
64. Preston L.C., Ashley C.C., and Redwood C.S. DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation. Biochem. Biophys. Res. Commun. 360 1 (2007) 27-32
65. Du C.K., Morimoto S., Nishii K., Minakami R., Ohta M., Tadano N., Lu Q.-W., Wang Y.Y., Zhan D.Y., Mochizuki M., Kita S., Miwa Y., Takahashi-Yanaga F., Iwamoto T., Ohtsuki I., and Sasaguri T. Knock-In Mouse Model of Dilated Cardiomyopathy Caused by Troponin Mutation. Circ. Res. 101 (2007) 185-194
66. Mogensen .J., Murphy R.T., Shaw T., Bahl A., Redwood C., Watkins H., Burke M., Elliott P.M., and McKenna W.J. Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 44 (2004) 2033-2040
67. Hanson E.L., Jakobs P.M., Keegan H., Coates K., Bousman S., Dienel N.H., Litt M., and Hershberger R.E. Cardiac troponin T lysine 210 deletion in a family with dilated cardiomyopathy. J. Card Fail. 8 (2002) 28-32
68. Alpert N.R., Brosseau C., Federico A., Krentz M., Robbins J., and Warshaw D.M. Molecular mechanisms of mouse cardiac myosin isoforms. Am. J. Physiol. 283 (2002) H1446-H1454
69. Korte F.S., Herron T.J., Rovetto M.J., and McDonald K.S. Power output is linearly related to MyHC content in rat skinned myocyte and isolated working hearts. Am. J. Physiol. 289 (2005) H801-H812
70. Robinson P., Mirza M., Knott A., Abdulrazzak H., Willott R., Marston S., Watkins H., and Redwood C. Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. J. Biol. Chem. 277 (2002) 40710-40716
71. Shiraishi F., Nakamura Y., and Ohtsuki I. Replacement of troponin in bullfrog skeletal myofibrils by rabbit skeletal and bovine cardiac troponins. Biomed. Res. 14 (1993) 993-997
72. Ohtsuki I. Functional organization the troponin-tropomyosin system. In: Ebashi S., et al. (Ed). Muscle contraction; Its regulatory mechanisms (1980), Japan Sci., Soc., Press, Springer-Verlag Berlin Heidelberg New York 237-250
73. 2+ -dependent regulation of muscle contraction. J. Mol. Biol. 271 (1997) 726-750