Molecular evidences of single mutational events followed by recurrent crossing-overs in the common δ-globin alleles in the Mediterranean area

Gene

Volumn 410, Issue 1, 2008, Pages 129-138

  Lacerra, Giuseppina ^a   Musollino, Gennaro ^a   Scarano, Clelia ^b   Lagona, Laura F ^c   Caruso, Daniela G ^d   Testa, Rosario ^d   Prezioso, Romeo ^a   Di Noce, Francesca ^a   Medulla, Emilia ^c   Friscia, Maria G ^e   Mastrullo, Lucia ^f   Caldora, Mercedes ^g   Nota, Lucia ^b   Gaudiano, Carlo ^h   Magnano, Carmelo ^c   Ciaccio, Calogero ^e   Romeo, Maria A ^d   Carestia, Clementina ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b OSPEDALI RIUNITI   (Italy)

^c ARNAS   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e Centro Trasfusionale e di Microcitemia   (Italy)

^f San Gennaro Hospital   (Italy)

^g Ospedale San Giovanni Bosco   (Italy)

^h Ospedale Civile   (Italy)

Author keywords

Genome variability; Haplotypes and SNPs; Human globin gene; Mutation origin and spreading

Indexed keywords

DELTA GLOBIN; HEMOGLOBIN A2; HEMOGLOBIN C; HEMOGLOBIN S; MICROSATELLITE DNA;

ALLELE; ARTICLE; CHROMOSOME; CROSSING OVER; ETHNIC GROUP; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC RECOMBINATION; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTHERN EUROPE; THALASSEMIA;

ALLELES; BASE SEQUENCE; CROSSING OVER, GENETIC; DNA PRIMERS; GLOBINS; HAPLOTYPES; HUMANS; MEDITERRANEAN REGION; MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 40849092534     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2007.12.004     Document Type: Article

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