Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide

Brain Research

Volumn 1201, Issue , 2008, Pages 143-150

  Kiewert, Cornelia ^a   Kumar, Vikas ^a   Hildmann, Oksana ^b   Hartmann, Joachim ^a   Hillert, Markus ^a   Klein, Jochen ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Edema formation; Excitotoxicity; Ginkgo biloba; Glycine receptor; Ischemia; Oxygen glucose deprivation

Indexed keywords

4 AMINOBUTYRIC ACID; BILOBALIDE; CHLORINE 36; CHOLINE; GLUCOSE; GLUTAMIC ACID; GLYCINE; GLYCINE RECEPTOR; MEMBRANE PHOSPHOLIPID; N METHYL DEXTRO ASPARTIC ACID; OXYGEN; SERINE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN SLICE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; CYTOTOXICITY; GINKGO BILOBA; HIPPOCAMPUS; MALE; NEUROCHEMISTRY; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; WATER CONTENT;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRAIN EDEMA; BRAIN ISCHEMIA; CHLORIDES; CHOLINE; CYCLOPENTANES; EXCITATORY AMINO ACID AGONISTS; FURANS; GINKGOLIDES; GLYCINE; HIPPOCAMPUS; MALE; MEMBRANE LIPIDS; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE;

GINKGO BILOBA; RATTUS;

EID: 40849087706     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.01.052     Document Type: Article

References (37)

1. Ahlemeyer B., and Krieglstein J. Neuroprotective effects of Ginkgo biloba extract. Cell. Mol. Life Sci. 60 (2003) 1779-1792
2. Bastianetto S., Ramassamy C., Dore S., Christen Y., Poirier J., and Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by ß-amyloid. Eur. J. Neurosci. 12 (2000) 1882-1890
3. Berger A.J., Dieudonne S., and Ascher P. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol. 80 (1998) 3336-3340
4. Bloomquist J.R., and Soderlund D.M. Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles. Biochem. Biophys. Res. Commun. 133 (1985) 37-43
5. Chandrasekaran K., Mehrabian Z., Spinnewyn B., Drieu K., and Fiskum G. Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb761), in gerbil global brain ischemia. Brain Res. 922 (2001) 282-292
6. Chatterjee S.S., Kondratskaya E.L., and Krishtal O.A. Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. Pharmacopsychiatry 36 Suppl. 1 (2003) S68-S77
7. Colciaghi F., Borroni B., Zimmermann M., Bellone C., Longhi A., Padovani A., Cattabeni F., Christen Y., and Di Luca M. Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts. Neurobiol. Dis. 16 (2004) 454-460
8. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 65 (2001) 1-105
9. Danysz W., and Parsons C.G. Glycine and N-methyl-d-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev. 50 (1998) 597-659
10. Davies J.A., Johns L., and Jones F.A. Effects of bilobalide on cerebral amino acid neurotransmission. Pharmacopsychiatry 36 Suppl. 1 (2003) S84-S88
11. DeFeudis F.V. Bilobalide and neuroprotection. Pharmacol. Res. 46 (2002) 565-568
12. DeFeudis F.V., and Drieu K. Ginkgo biloba extract (EGb761) and CNS functions: basic studies and clinical applications. Curr. Drug Targets 1 (2000) 25-58
13. Eulenburg V., Armsen W., Betz H., and Gomeza J. Glycine transporters: essential regulators of neurotransmission. Trends Biochem. Sci. 30 (2005) 325-333
14. Hawthorne R., and Lynch J.W. A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop. J. Biol. Chem. 280 (2005) 35836-35843
15. Hollingsworth E.B., McNeal E.T., Burton J.L., Williams R.J., Daly J.W., and Creveling C.R. Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex. J. Neurosci. 5 (1985) 2240-2253
16. A receptors. Eur. J. Pharmacol. 464 (2003) 1-8
17. Huettner J.E. Competitive antagonism of glycine at the N-methyl-d-aspartate (NMDA) receptor. Biochem. Pharmacol. 41 (1990) 9-16
18. A receptors. J. Biol. Chem. 278 (2003) 49279-49285
19. Kiewert C., Kumar V., Hildmann O., Rueda M., Hartmann J., Naik R.S., and Klein J. Role of GABAergic antagonism in the neuroprotective effects of bilobalide. Brain Res. 1128 (2007) 70-78
20. Klein J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J. Neural Transm. 107 (2000) 1027-1063
21. Klein J., Chatterjee S.S., and Löffelholz K. Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba. Brain Res. 755 (1997) 347-350
22. Klein J., Weichel O., Hilgert M., Rupp J., Chatterjee S.S., and Nawrath H. Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes. Pharmacopsychiatry 36 Suppl. 1 (2003) S78-S83
23. Krieglstein J., Ausmeier F., El-Abhar H., Lippert K., Welsch M., Ruppalla K., and Henrich-Noack P. Neuroprotective effects of Ginkgo biloba constituents. Eur. J. Pharm. Sci. 3 (1995) 39-48
24. Luo Y., Smith J.V., Paramavisam V., Burdick A., Curry K.J., Buford J.P., Khan I., Netzer W.J., Xu H., and Butko P. Inhibition of amyloid-ß aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12197-12202
25. Lynch J.W. Molecular structure and function of the glycine receptor chloride channel. Physiol. Rev. 84 (2004) 1051-1095
26. MacGregor D.G., Avshalumov M.V., and Rice M.E. Brain edema induced by in vitro ischemia: causal factors and neuroprotection. J. Neurochem. 85 (2003) 1402-1411
27. Mdzinarishvili A., Kiewert C., Kumar V., Hillert M., and Klein J. Bilobalide prevents ischemia-induced edema formation in vitro and in vivo. Neuroscience 144 (2006) 217-222
28. Oken B.S., Storzbach D.M., and Kaye J.A. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch. Neurol. 55 (1998) 1409-1415
29. Saransaari P., and Oja S.S. Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors. Mech. Ageing Dev. 76 (1994) 113-124
30. Saransaari P., and Oja S.S. Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. Neurochem. Res. 26 (2001) 845-852
31. Sasaki K., Hatta S., Wada K., Itoh M., Yoshimura T., and Haga M. Effects of chronic administration of bilobalide on amino acid levels in mouse brain. Cell. Mol. Biol. (Noisy-le-grand) 48 (2002) 681-684
32. Schell M.J., Molliver M.E., and Snyder S.H. d-Serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 3948-3952
33. Tsai G., Ralph-Williams R.J., Martina M., Bergeron R., Berger-Sweeney J., Dunham K.S., Jiang Z., Caine S.B., and Coyle J.T. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 8485-8490
34. Vogel H.G., and Vogel W.H. Drug discovery and evaluation: pharmacological assays (2002), Springer electronic media, Heidelberg, Germany
35. 2 activation and phospholipid breakdown in rat hippocampus. Naunyn-Schmiedeberg's Arch. Pharmacol 360 (1999) 609-615
36. Weinges K., and Bähr W. Kondensierte Ringsysteme II. Bilobalid, ein neues Sesquiterpen mit tertiärer Butylgruppe aus den Blättern von Ginkgo biloba L. Liebig's Ann. Chem. 724 (1969) 214-216
37. Wood P.L. The co-agonist concept: is the NMDA-associated glycine receptor saturated in vivo?. Life Sci. 57 (1995) 301-310