The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients

Journal of Critical Care

Volumn 23, Issue 1, 2008, Pages 11-17

  Delisle, Marie Soleil ^a   Williamson, David R ^b,c   Perreault, Marc M ^c,d   Albert, Martin ^b,c   Jiang, Xuran ^e   Heyland, Daren K ^e  

^a LAVAL UNIVERSITY   (Canada)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e QUEEN S UNIVERSITY   (Canada)

Author keywords

Candida; Candida airway colonization; colonization; Critical care; Pneumonia; Ventilator associated pneumonia

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; FLUCONAZOLE;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CANDIDA; COMBINATION CHEMOTHERAPY; COMORBIDITY; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; FEMALE; FUNGUS ISOLATION; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORBIDITY; MORTALITY; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTION; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SECRETION; SEX RATIO;

BRONCHOSCOPY; CANADA; CANDIDIASIS; COLONY COUNT, MICROBIAL; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; RESPIRATORY SYSTEM; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 40849083565     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2008.01.005     Document Type: Article

References (25)

1. Banerjee S.N., Emori T.G., Culver D.H., Gaynes R.P., Jarvis W.R., Horan T., et al. Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989. Am J Med 91 (1991) 86S-89S
2. Beck-Sagué C.M., and Jarvis W. Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System. J Infect Dis 167 (1993) 1247-1251
3. Vincent J.L., Bihari D.J., Suter P.M., et al. The prevalence of nosocomial infection in intensive care units in Europe: results of the European Prevalence of Infection in Intensive Care (EPIC) Study; EPIC International Advisory Committee. JAMA 274 (1995) 639-644
4. Rangel-Frausto M.S., Wiblin T., Blumberg H.M., Saiman L., Patterson J., Rinaldi M., et al. National epidemiology of mycoses survey (NEMIS): variations in rate of bloodstream infections due to Candida sp. in seven surgical intensive care units and six neonatal intensive care units. Clin Infect Dis 29 (1999) 253-258
5. Wey S.B., Mori M., Pfaller M.A., Woolson R.F., and Wenzel R.P. Hospital-acquired candidemia: the attributable mortality and excess length of stay. Arch Intern Med 148 (1988) 2642-2645
6. Wenzel R.P. Nosocomial candidemia: risk factors and attributable mortality. Clin Infect Dis 20 (1995) 1531-1534
7. Rentz A.M., Halpern M.T., and Bowden R. The impact of candidemia on length of hospital stay, outcome and overall cost of illness. Clin Infect Dis 27 (1998) 781-788
8. Charles P.E., Doise J.M., Quenot J.P., Aube H., Dalle F., Chavanet P., et al. Candidemia in critically ill patients : difference of outcome between medical and surgical patients. Intern Care Med 29 (2003) 2162-2169
9. Pittet D., Monod M.M., Suter P.M., Frenk E., and Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg 220 6 (1994) 751-758
10. Olaechea P.M., Palomar M., Léon-Gil C., Álvarez-Lerma F., Jordá R., Nolla-Salas J., et al. Economic impact of Candida colonization and Candida infection in the critically ill patient. Eur J Clin Microbiol Infect Dis 23 (2004) 323-330
11. Charles P.E., Dalle F., Aube H., Doise J.M., Quenot J.P., and Aho L.S. Candida spp. colonization significance in critically ill medical patients: a prospective study. Intensive Care Med 31 (2005) 393-400
12. Azoulay E., Cohen Y., Zahar J.R., Garrouste-Orgeas M., Adrie C., Moine P., et al. Practices in non neutropenic ICU patients with Candida-positive airway specimens. Intensive Care Med 30 (2004) 1384-1389
13. Wey S.B., Mori M., Pfaller M.A., Woolson R.F., and Wenzel R.P. Risk factors for hospital-acquired candidemia. A matched case-control study. Arch Intern Med 149 (1989) 2349-2353
14. Fraser V.J., Jones M., Dunkel J., Storfer S., Medoff G., and Dunagan W.C. Candidemia in a tertiary care hospital: epidemiology, risk factors and predictors of mortality. Clin Infect Dis 15 (1992) 414-421
15. Jarvis W.R. Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clin Infect Dis 20 (1995) 1526-1530
16. Bross J., Talbot G.H., Maislin G., Hurwitz S., and Strom B.L. Risk factors for nosocomial candidemia: a case-control study in adults without leukemia. Am J Med 87 (1989) 614-620
17. Eggiman P., and Pittet D. Candidoses du sujet non neutropénique: de la colonisation à l'infection. Ann Fr Anesth Réanim 20 (2001) 382-388
18. El-Ebiary M., Torres A., Fàbregas N., Puig de la Bellacasa J., González J., Ramirez J., et al. Significance of the isolation of Candida species from respiratory samples in critically ill, non neutropenic patients. Am J Respir Crit Care Med 156 (1997) 583-590
19. Rello J., Esandi M.E., Díaz E., Mariscal D., Gallego M., and Vallès J. The role of Candida sp isolates from bronchoscopic samples in nonneutropenic patients. Chest 114 (1998) 146-149
20. Wood C., Mueller E.W., Croce M.A., et al. Candida sp. isolated from bronchoalveolar lavage: clinical significance in critically ill trauma patients. Intensive Care Med 32 4 (2006) 599-603
21. Azoulay E., Timsit J.F., Tafflet M., de Lassence A., Darmon M., Zahar J.R., et al. Candida colonization of the respiratory tract and subsequent Pseudomonas ventilator-associated pneumonia. Chest 129 (2006) 110-117
22. Heyland D., Dodek P., Muscedere J., and Day A. A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med 355 (2006) 2619-2630
23. Knaus W.A., Draper E.A., Wagner D.P., and Zimmerman J.E. APACHE II: a severity of disease classification system. Crit Care Med 13 (1985) 818-829
24. Marshall J.C., Cook D.J., Christou N.V., Bernard G.R., Sprung C.L., and Sibbald W.J. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23 (1995) 1638-1652
25. Nseir S., Jozefowicz E., Cavestri B., et al. Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study. Intensive Care Med 33 1 (2007) 137-142