Allopurinol mouthwash for prevention or alleviation radiotherapy induced oral mucositis: A randomized, placebo-controlled trial

Daru

Volumn 15, Issue 4, 2007, Pages 227-230

  Abbasi Nazari, M ^a   Sadrolhefazi, B ^a   Nikoofar, A ^b   Erfan, M ^a   Azizian, H ^c   Alamy, M ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allopurinol; Mouthwash; Oral mucositis; Radiotherapy

Indexed keywords

ALLOPURINOL; CISPLATIN; PLACEBO;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG STABILITY; FEMALE; HUMAN; HYPOPHARYNX CANCER; MALE; MOUTH CANCER; MOUTHWASH; MUCOSA INFLAMMATION; NASOPHARYNX CANCER; RANDOMIZED CONTROLLED TRIAL; SUSPENSION;

EID: 40749162806     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. th ed. New York: Williams & Wilkines.2005: 8-10
2. Duncan M, Grant G. Oral and intestinal mucositis- causes and possible treatments. Alim Pharmacol Ther.2003; 18: 853-874
3. Bensadoun R, Magne N, Marcy P, Demard F. Chemotherapy and radiotherapy induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment. Eur Arch Otorhinolaryngol. 2001;258:481-487.
4. Oredsson S, Plate G, Qvarfordt P. Allopurinol- free radical scavenger - reduces reperfusion injury in skeletal muscle. 1991;5:47-52.
5. Loprinzi CL, Cianflone SG, Dose AM, Etzell PS, Burnham NL et al . A controlled evaluation of an allopurinal mouthwash as prophylaxis against 5-flurouracil induced stomatitis. Cancer. 1990;65:1879-1882.
6. Clarke PZ, Slevin ML. Allopurinol mouthwash and 5-fluorouracil induced oral toxicity. Eur Surg Oncol. 1985;11:267-8
7. Montecucco C Caporali R, Rossi S, Porta C. Allopurinol mouthwash in methotrexate- induced stomatitis. Arthritis Rheum. 1994;37:777-778
8. Tsavaris N, Caragiauris P, Kosmidis P. Reduction of oral toxicity of 5- fluorouracil by allopurinal mouthwash. Eur Surg Oncol. 1988;14: 405-6.