Distribution of Free and Liposomal Doxorubicin After Isolated Lung Perfusion in a Sarcoma Model

Annals of Thoracic Surgery

Volumn 85, Issue 4, 2008, Pages 1225-1232

  Yan, Hua ^a   Cheng, Cai ^a   Haouala, Amina ^a   Krueger, Thorsten ^a   Ballini, Jean Pierre ^a   Peters, Solange ^a   Decosterd, Laurent A ^a   Letovanec, Igor ^b   Ris, Hans Beat ^a   Andrejevic Blant, Snezana ^b  

^a EPFL   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG UPTAKE; FISCHER 344 RAT; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; LIPOSOMAL DELIVERY; LUNG CAPILLARY; LUNG PARENCHYMA; LUNG PERFUSION; LUNG SARCOMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE SECTION; TUMOR VASCULARIZATION;

ANIMALS; CELL LINE, TUMOR; CHEMOTHERAPY, CANCER, REGIONAL PERFUSION; DISEASE MODELS, ANIMAL; DOXORUBICIN; LIPOSOMES; LUNG NEOPLASMS; MALE; PROBABILITY; RANDOM ALLOCATION; RATS; RATS, INBRED F344; REFERENCE VALUES; SARCOMA, EXPERIMENTAL; SENSITIVITY AND SPECIFICITY;

EID: 40749162733     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2007.12.028     Document Type: Article

References (29)

1. Minchin R.F., Johnston M.R., Aiken M.A., and Boyd M.R. Pharmacokinetics of doxorubicin in isolated lung of dogs and humans perfused in vivo. J Pharmacol Exp Ther 229 (1984) 193-198
2. Johnston M.R., Minchen R.F., and Dawson C.A. Lung perfusion with chemotherapy in patients with unresectable metastatic sarcoma to the lung or diffuse bronchioloalveolar carcinoma. J Thorac Cardiovasc Surg 110 (1995) 368-373
3. Burt M.E., Liu D., Abolhoda A., et al. Isolated lung perfusion for patients with unresectable metastases from sarcoma: a phase I trial. Ann Thorac Surg 69 (2000) 1542-1549
4. Ratto G.B., Toma S., Civalleri D., et al. Isolated lung perfusion with platinum in the treatment of pulmonary metastases from soft tissue sarcomas. J Thorac Cardiovasc Surg 112 (1996) 614-622
5. Pass H.I., Mew D.J., Lranda K.C., Temeck B.K., Donington J.S., and Rosenberg S.A. Isolated lung perfusion with tumor necrosis factor for pulmonary metastases. Ann Thorac Surg 61 (1996) 1609-1617
6. Putnam J.B. New and evolving treatment methods for pulmonary metastases. Semin Thorac Cardiovasc Surg 14 (2002) 49-56
7. Schroder C., Fisher S., Pieck A.C., et al. Technique and results of hyperthermic (41°C) isolated lung perfusion with high-doses of cisplatin for the treatment of surgically relapsing or unresecable lung sarcoma metastases. Eur J Cardiothorac Surg 22 (2002) 41-46
8. Hendriks J.M., Grootenboers M.J., Schramel F.M., et al. Isolated lung perfusion with melphalan for resectable lung metastases: a phase I clinical trial. Ann Thorac Surg 78 (2004) 1919-1927
9. Weksler B., Schneider A., Ng B., and Burt M.E. Isolated single lung perfusion in the rat: an experimental model. J Appl Physiol 74 (1993) 2736-2739
10. Weksler B., Ng B., Lenert J.T., and Burt M.E. Isolated single lung perfusion with doxorubicin is pharmacokinetically superior to intravenous injection. Ann Thorac Surg 56 (1993) 209-214
11. Weksler B., Lenert J., Ng B., and Burt M. Isolated lung perfusion with doxorubicin is effective in eradicating soft tissue sarcoma lung metastases in a rat model. J Thorac Cardiovasc Surg 107 (1994) 50-54
12. Abolhoda A., Brooks A., Nawata S., Kaneda Y., Cheng H., and Burt M. Isolated lung perfusion with doxorubicin prolongs survival in a rodent model of pulmonary metastases. Ann Thorac Surg 64 (1997) 181-184
13. Furrer M., Lardinois D., Thormann W., et al. Isolated lung lung perfusion: single-pass system versus recirculating blood perfusion in pigs. Ann Thorac Surg 65 (1998) 1420-1425
14. Furrer M., Lardinois D., Thormann W., et al. Cytostatic lung perfusion by use of an endovascular blood occlusion technique. Ann Thorac Surg 65 (1998) 1523-1528
15. Weksler B., and Burt M. Isolated lung perfusion with antineoplastic agents for pulmonary metastases. Chest Surg Clin N Am 8 (1998) 157-182
16. Krueger T., Kuemmerle A., Kosinski M., et al. Cytostatic lung perfusion results in heterogeneous spatial regional blood flow and drug distribution. Evaluation of different cytostatic lung perfusion techniques in a porcine model. J Thorac Cardiovasc Surg 132 (2006) 304-311
17. Papahadjopoulos D., Allen T.M., Gabizon A., et al. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci U S A 88 (1991) 11460-11464
18. Gabizon A.A. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res 52 (1992) 891-896
19. Lyass O., Uziely B., Ben-Yosef R., et al. Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma. Cancer 89 (2000) 1037-1047
20. Harrington K.J., Mohammadtaghi S., Uster P.S., et al. Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res 7 (2001) 243-254
21. Pan Y., Krueger T., Tran N., Yan H., Ris H.B., and McKee T.A. Evaluation of tumor vascularisation in two rat sarcoma models for studying isolated lung perfusion. Injection route determines the origin of tumor vessels. Eur Surg Res 37 (2005) 92-99
22. Kuemmerle A., Krueger T., Dusmet M., et al. A validated assay for measuring doxorubicin in biological fluids in an isolated lung perfusion model: matrix effect and heparin interference strongly influence doxorubicin measurements. J Pharm Biomed Anal 33 (2003) 475-494
23. Chin D.L., Lum B.L., and Sikic B.I. Rapid determination of pegylated liposomal doxorubicin and its major metabolite in human plasma by ultraviolet visible high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 779 (2002) 259-269
24. Andrejevic-Blant S., Hadjur C., Ballini J.P., et al. Photodynamic therapy of early squamous cell carcinoma with tetra (m-hydroxyphenyl) chlorin: optimal drug-light interval. Br J Cancer 76 (1997) 1021-1028
25. Rasband W.S. ImageJ (1997-2007), US National Institutes of Health, Betheseda, MD. http://rsb.info.nih.gov/ij/ Available at: http://rsb.info.nih.gov/ij/
26. Jain R.K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev 6 (1987) 559-593
27. Krueger T., Kuemmerle A., Andrejevic-Blant S., et al. Antegrade versus retrograde isolated lung perfusion: Doxorubicin uptake and distribution in a sarcoma model. Ann Thorac Surg 82 (2006) 2024-2030
28. Pusztaszeri M.P., Seelentag W., and Bosman F.T. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 54 (2006) 385-395
29. Primeau A.J., Rendon A., Hedley D., Lilge L., and Tannock I.F. The distribution of the anticancer drug doxorubicin in relation to blood vessels in solid tumors. Clin Cancer Res 11 (2005) 8782-8788