Simultaneous occurrence of the JAK2V617F mutation and BCR-ABL gene rearrangement in patients with chronic myeloproliferative disorders

Leukemia Research

Volumn 32, Issue 6, 2008, Pages 993-995

  Kim, Yeo Kyeoung ^a   Shin, Myung Geun ^a,b   Kim, Hye Ran ^b   Yang, Deok Hwan ^a   Cho, Sang Hee ^a   Lee, Je Jung ^a   Chung, Ik Joo ^a   Ryang, Dong Wook ^a   Kim, Hyeoung Joon ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Hwasun Hospital and Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; JANUS KINASE 2; NILOTINIB;

ADULT; ANAMNESIS; CANCER PATIENT; CASE REPORT; CLINICAL EXAMINATION; CLINICAL FEATURE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; GENE MUTATION; HUMAN; LETTER; MALE; MYELOPROLIFERATIVE DISORDER; PHILADELPHIA CHROMOSOME NEGATIVE CELL; PRIORITY JOURNAL;

CHRONIC DISEASE; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; JANUS KINASE 2; MALE; MIDDLE AGED; MUTATION; MYELOPROLIFERATIVE DISORDERS; PROTEIN-TYROSINE KINASES;

EID: 40749148842     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2007.10.018     Document Type: Letter

References (6)

1. Baxter E.J., Scott L.M., Campbell P.J., East C., Fourouclas N., Swanton S., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365 (2005) 1054-1061
2. Curtin N.J., Campbell P.J., and Green A.R. The Philadelphia translocation and pre-existing myeloproliferative disorders. Br J Haematol 128 (2005) 734-736
3. Kramer A., Reiter A., Kruth J., et al. JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia. Lancet Oncol 8 (2007) 658-660
4. Xie S., Lin H., Sun T., and Arlinghaus R.B. Jak2 is involved in c-Myc induction by Bcr-Abl. Oncogene 21 (2002) 7137-7146
5. Coppo P., Flamant S., De Mas V., Jarrier P., Guillier M., Bonnet M.L., et al. BCR-ABL activates STAT3 via JAK and MEK pathways in human cells. Br J Haematol 134 (2006) 171-179
6. Kronenwett R., Gräf T., Neumann F., Pechtel S., Steidl U., Diaz-Blanco E., et al. Absence of the JAK2 mutation V617F in CD34+ hematopoietic stem and progenitor cells from patients with BCR-ABL-positive CML in chronic phase and blast crisis. Leuk Res 30 (2006) 1323-1324