Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2109-2113

  Timmons, Amy ^a   Seierstad, Mark ^a   Apodaca, Rich ^a   Epperson, Matt ^a   Pippel, Dan ^a   Brown, Sean ^a   Chang, Leon ^a   Scott, Brian ^a   Webb, Michael ^a   Chaplan, Sandra R ^a   Breitenbucher, J Guy ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Endocannabinoid; FAAH; Fatty acid amide hydrolase; Pain

Indexed keywords

FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; KETOOXAZOLE DERIVATIVE; OL 135; OXAZOLE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLODYNIA; ARTICLE; DISEASE MODEL; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IC 50; NERVE LIGATION; NEUROPATHIC PAIN; REACTION ANALYSIS; SPINAL NERVE; STRUCTURE ANALYSIS;

AMIDOHYDROLASES; ANIMALS; BINDING SITES; HUMANS; OXAZOLES; PAIN; PAIN MEASUREMENT; PYRIDINES; RATS; SPINAL NERVES; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 40749130801     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.091     Document Type: Article

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