Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2183-2187

  Colabufo, Nicola Antonio ^a   Abate, Carmen ^a   Contino, Marialessandra ^a   Inglese, Carmela ^a   Ferorelli, Savina ^a   Berardi, Francesco ^a   Perrone, Roberto ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

3H PB28; Sigma 2 receptors

Indexed keywords

1 CYCLOHEXYL 4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZINE H 3; HALOPERIDOL; PB 28; PENTAZOCINE; PIPERAZINE DERIVATIVE; RADIOLIGAND; SIGMA 2 OPIATE RECEPTOR; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; ISOTOPE LABELING; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR OCCUPANCY;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL MEMBRANE; LIVER; MOLECULAR STRUCTURE; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; RNA, MESSENGER; TRITIUM;

EID: 40749123571     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.056     Document Type: Article

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