Effects of levosimendan on left ventricular relaxation and early filling at maintained preload and afterload conditions after aortic valve replacement for aortic stenosis

Circulation

Volumn 117, Issue 8, 2008, Pages 1075-1081

  Jörgensen, Kirsten ^a,b,c   Bech Hanssen, Odd ^a   Houltz, Erik ^a   Ricksten, Sven Erik ^a,b  

^a Department of Cardiothoracic Anesthesia and Intensive Care ^*

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Diastole; Echocardiography; Hypertrophy; Simendan; Stenosis

Indexed keywords

HYPERTENSIVE FACTOR; LEVOSIMENDAN; PLACEBO; CARDIOTONIC AGENT; HYDRAZONE DERIVATIVE; PYRIDAZINE DERIVATIVE; SIMENDAN; UNCLASSIFIED DRUG;

AGED; AORTA STENOSIS; AORTA VALVE REPLACEMENT; ARTICLE; CATHETERIZATION; CENTRAL VENOUS PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; COLLOID; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DIASTOLE; DIASTOLIC BLOOD PRESSURE; DOPPLER ECHOCARDIOGRAPHY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HEART AFTERLOAD; HEART ATRIUM PACING; HEART HEMODYNAMICS; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE FILLING PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE PERFORMANCE; HEART LEFT VENTRICLE RELAXATION; HEART LEFT VENTRICLE SIZE; HEART MUSCLE RELAXATION; HEART OUTPUT; HEART PERFORMANCE; HEART PRELOAD; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HUMAN; LOADING DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RELAXATION TIME; SINGLE BLIND PROCEDURE; SYSTEMIC VASCULAR RESISTANCE; SYSTOLIC BLOOD PRESSURE; THERMODILUTION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TWO DIMENSIONAL ECHOCARDIOGRAPHY; AORTA VALVE STENOSIS; BLOOD PRESSURE; ECHOCARDIOGRAPHY; ECHOGRAPHY; HEART VALVE REPLACEMENT; MITRAL VALVE; PATHOPHYSIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME; VASCULAR RESISTANCE;

AGED; AGED, 80 AND OVER; AORTIC VALVE STENOSIS; BLOOD PRESSURE; CARDIOTONIC AGENTS; DIASTOLE; ECHOCARDIOGRAPHY; FEMALE; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; HYDRAZONES; HYPERTROPHY, LEFT VENTRICULAR; MALE; MITRAL VALVE; PYRIDAZINES; STROKE VOLUME; TREATMENT OUTCOME; VASCULAR RESISTANCE; VENTRICULAR FUNCTION, LEFT;

EID: 40749120271     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.722868     Document Type: Article

References (32)

1. Slawsky MT, Colucci WS, Gottlieb SS, Greenberg BH, Haeusslein E, Hare J, Hutchins S, Leier CV, LeJemtel TH, Loh E, Nicklas J, Ogilby D, Singh BN, Smith W. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure: Study Investigators. Circulation. 2000;102:2222-2227.
2. Lehmann A, Boldt J, Kirchner J. The role of Ca++-sensitizers for the treatment of heart failure. Curr Opin Crit Care. 2003;9:337-344.
3. McBride BF, White CM. Levosimendan: implications for clinicians. J Clin Pharmacol. 2003;43:1071-1081.
4. Grossman W. Diastolic function and heart failure: an overview. Eur Heart J. 1990;11(suppl C):2-7.
5. Hajjar RJ, Schmidt U, Helm P, Gwathmey JK. Ca++ sensitizers impair cardiac relaxation in failing human myocardium. J Pharmacol Exp Ther. 1997;280:247-254.
6. Janssen PM, Datz N, Zeitz O, Hasenfuss G. Levosimendan improves diastolic and systolic function in failing human myocardium. Eur J Pharmacol. 2000;404:191-199.
7. Dernellis J, Panaretou M. Effects of levosimendan on restrictive left ventricular filling in severe heart failure: a combined hemodynamic and Doppler echocardiographic study. Chest. 2005;128:2633-2639.
8. Parissis JT, Panou F, Farmakis D, Adamopoulos S, Filippatos G, Paraskevaidis I, Venetsanou K, Lekakis J, Kremastinos DT. Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure. Am J Cardiol. 2005;96:423-426.
9. De Luca L, Sardella G, Proietti P, Battagliese A, Benedetti G, Di Roma A, Fedele F. Effects of levosimendan on left ventricular diastolic function after primary angioplasty for acute anterior myocardial infarction: a Doppler echocardiographic study. J Am Soc Echocardiogr. 2006;19:172-177.
10. Thomas JD, Flachskampf FA, Chen C, Guererro JL, Picard MH, Levine RA, Weyman AE. Isovolumic relaxation time varies predictably with its time constant and aortic and left atrial pressures: implications for the noninvasive evaluation of ventricular relaxation. Am Heart J. 1992;124:1305-1313.
11. Harrison MR, Clifton GD, Pennell AT, DeMaria AN. Effect of heart rate on left ventricular diastolic transmitral flow velocity patterns assessed by Doppler echocardiography in normal subjects. Am J Cardiol. 1991;67:622-627.
12. Oniki T, Hashimoto Y, Shimizu S, Kakuta T, Yajima M, Numano F. Effect of increasing heart rate on Doppler indices of left ventricular performance in healthy men. Br Heart J. 1992;68:425-429.
13. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1:307-310.
14. Pagel PS, Grossman W, Haering JM, Warltier DC. Left ventricular diastolic function in the normal and diseased heart: perspectives for the anesthesiologist (1). Anesthesiology. 1993;79:836-854.
15. Lewis BS, Lewis N, Sapoznikov D, Gotsman MS. Isovolumic relaxation period in man. Am Heart J. 1980;100:490-499.
16. Myreng Y, Smiseth OA. Assessment of left ventricular relaxation by Doppler echocardiography: comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation. Circulation. 1990;81:260-266.
17. Ochi H, Ikuma I, Toda H, Shimada T, Morioka S, Moriyama K. Isovolumic relaxation period as an index of left ventricular relaxation under different afterload conditions: comparison with the time constant of left ventricular pressure decay in the dog. Jpn Circ J. 1989;53:1521-1529.
18. Yellin EL, Hori M, Yoran C, Sonnenblick EH, Gabbay S, Frater RW. Left ventricular relaxation in the filling and nonfilling intact canine heart. Am J Physiol. 1986;250:H620-H629.
19. Sidebotham D, Merry A, Legget M. Practical Perioperative Transoesophageal Echocardiography. Edinburgh, UK: Butterworth-Heinemann; 2003.
20. Garcia MJ, Thomas JD, Klein AL. New Doppler echocardiographic applications for the study of diastolic function. J Am Coll Cardiol. 1998;32:865-875.
21. Oh JK, Appleton CP, Hatle LK, Nishimura RA, Seward JB, Tajik AJ. The noninvasive assessment of left ventricular diastolic function with twodimensional and Doppler echocardiography. J Am Soc Echocardiogr. 1997;10:246-270.
22. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440-1463.
23. Skarvan K, Lambert A, Filipovic M, Seeberger M. Reference values for left ventricular function in subjects under general anaesthesia and controlled ventilation assessed by two-dimensional transoesophageal echocardiography. Eur J Anaesthesiol. 2001;18:713-722.
24. Hgashiyama A, Watkins MW, Chen Z, LeWinter MM. Effects of EMD 57033 on contraction and relaxation in isolated rabbit hearts. Circulation. 1995;9:3094-3104.
25. Haikala H, Nissinen E, Etemadzadeh E, Levijoki J, Linden IB. Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation. J Cardiovasc Pharmacol. 1995;25:794-801.
26. Haikala H, Linden IB. Mechanisms of action of calcium-sensitizing drugs. J Cardiovasc Pharmacol. 1995;26(suppl 1):S10-S19.
27. Zimmermann N, Boknik P, Gams E, Herzig JW, Neumann J, Scholz H. Calcium sensitization as new principle of inotropic therapy in end-stage heart failure? Eur J Cardiothorac Surg. 1998;14:70-75.
28. Ajiro Y, Hagiwara N, Katsube Y, Sperelakis N, Kasanuki H. Levosimendan increases L-type Ca(2+) current via phosphodiesterase-3 inhibition in human cardiac myocytes. Eur J Pharmacol. 2002;435:27-33.
29. Hasenfuss G, Pieske B, Castell M, Kretschmann B, Maier LS, Just H. Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium. Circulation. 1998;98:2141-2147.
30. LeWinter MM, Fabian J, Bell SP. Left ventricular restoring forces: modulation by heart rate and contractility. Basic Res Cardiol. 1998;93(suppl 1):143-147.
31. Maslow AD, Regan MM, Schwartz C, Bert A, Singh A. Inotropes improve right heart function in patients undergoing aortic valve replacement for aortic stenosis. Anesth Analg. 2004;9:891-902.
32. Bartunek J, Sys SU, Rodrigues AC, van Schuerbeeck E, Mortier L, de Bruyne B. Abnormal systolic intraventricular flow velocities after valve replacement for aortic stenosis: mechanisms, predictive factors, and prognostic significance. Circulation. 1996;93:712-719.