Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2128-2132

  Aoki, Tomiyoshi ^a   Asaki, Tetsuo ^a   Hamamoto, Taisuke ^a   Sugiyama, Yukiteru ^a   Ohmachi, Shinji ^a   Kuwabara, Kenji ^a   Murakami, Kohji ^a   Todo, Makoto ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

1,3 Dioxane carboxylic acid; Metabolic disorder; PPAR agonist

Indexed keywords

2 METHYL 5 [4 (5 METHYL 2 PHENYL 1,3 OXAZOL 4 YL)BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERLIPIDEMIA; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIOXANES; DISEASE MODELS, ANIMAL; HUMANS; HYPOGLYCEMIC AGENTS; LIPOPROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; OXAZOLES; PPAR ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

MUS;

EID: 40749118856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.086     Document Type: Article

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