Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether

Journal of Photochemistry and Photobiology B: Biology

Volumn 90, Issue 3, 2008, Pages 179-186

  Wang, Rui ^a   Hao, Haiping ^a   Wang, Guangji ^a   Xie, Haitang ^a   Xu, Meijuan ^a   Wang, Wei ^a   He, Hui ^a   Li, Xiaoyu ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Deuxemether; Elimination; MRP2; Pharmacokinetics; Protein binding; Tissue distribution

Indexed keywords

ANTINEOPLASTIC AGENT; BROMSULFOPHTHALEIN; DEUTEROPORPHYRIN DERIVATIVE; DEUXEMETHER; DIGOXIN; PROBENECID; UNCLASSIFIED DRUG;

ARTICLE; COMPARTMENT MODEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG PROTEIN BINDING; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RAT; SOLID TUMOR; TISSUE DISTRIBUTION;

ANIMALS; BILIARY TRACT; BLOOD PROTEINS; DEUTEROPORPHYRINS; DIGOXIN; ENZYME INHIBITORS; FECES; HUMANS; INDICATORS AND REAGENTS; INFUSION PUMPS; PHOTOSENSITIZING AGENTS; PROBENECID; PROTOPORPHYRINS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SULFOBROMOPHTHALEIN; TIME FACTORS; TISSUE DISTRIBUTION; URICOSURIC AGENTS;

RATTUS;

EID: 40749109737     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2008.01.003     Document Type: Article

References (15)

1. Schuitmaker J.J., Bass P., van Leegoed H.L.L.M., van der Meulen F.W., Star W.M., and van zandwijk N. New trends in photobiology (invited review) photodynamic therapy: a promising new modality for the treatment of cancer. Journal of Photochemistry and Photobiology B: Biology 34 (1996) 3-12
2. Lottnerab C., Knuechelb R., Bernhardtc G., and Brunnera H. Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates. Cancer Letters 203 (2004) 171-180
3. Pazurek M., and Malecka-Panas E. Photodynamic therapy in the palliative treatment of esophageal cancer. Photodiagnosis and Photodynamic Therapy 2 (2005) 73-77
4. Moghissi K. Endoscopic photodynamic therapy (PDT) for oesophageal cancer. Photodiagnosis and Photodynamic Therapy 3 (2006) 93-95
5. Koren H., and Alth G. Photodynamic therapy in gynaecologic cancer. Journal of Photochemistry and Photobiology B: Biology 36 (1996) 189-191
6. Schaffer M., Schaffer P.M., Corti L., Gardiman M., Sotti G., Hofstetter A., Jori G., and Duḧmke E. Photofrin as a specific radiosensitizing agent for tumors: studies in comparison to other porphyrins, in an experimental in vivo model. Journal of Photochemistry and Photobiology B: Biology 66 (2002) 157-164
7. Bäumler W., Abels C., and Szeimies R.-m. Fluorescence diagnosis and photodynamic therapy in dermatology. Medical Laser Application 18 (2003) 47-56
8. Fardel O., Payen L., Courtois A., Vernhet L., and Lecureur V. Regulation of biliary drug efflux pump expression by hormones and xenobiotics. Toxicology 167 (2001) 37-46
9. Li X., Wang G., Xie H., Wang R., XU M., Wang W., Tao J., and Sun J. Simultaneous determination of MHD and DMD in dog plasma by high-performance liquid chromatography with fluorescence detection and its application to pharmacokinetic studies. Analytical and Bioanalytical Chemistry 384 (2006) 958-963
10. Lottner C., Knuechel R., Bernhardt G., and Brunner H. Distribution and subcellular localization of a water-soluble hematoporphyrin-platinum(II) complex in human bladder cancer cells. Cancer Letters 215 (2004) 167-177
11. Gabriela Alvarez M., Belen Rumie Vittar N., Principe F., Bergesse J., Cristina Romanini M., Romanini S., Bertuzzi M., Durantini E.N., and Rivarola V. Pharmacokinetic and phototherapeutic studies of monocationic methoxyphenylporphyrin derivative. Photodiagnosis and Photodynamic Therapy 1 (2004) 335-344
12. Hooiveld G.J., van Montfoort J.E., Meijer D.K., and Müller M. Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. European Journal of Pharmaceutical Science 12 4 (2001) 525-543 Feb
13. Roya B.K., Singhb K.K., Yadav K.P., Banerjee N.C., and Pandey H.K. Pharmacokinetics of cefazolin with and without probenecid in febrile goats. Small Ruminant Research 32 (1999) 13-19
14. Hong Z.X., Zhang Qing M.A., Qing G.C., and Guo S. Effects of probenecid on pharmacokinetics of cefaclor in rats. Chinese Journal Of Clinical Pharmacology and Therapeutics 9 (2004) 523-526
15. Sheng W.C., Ping L.X., Zhang Qing M.A., and Guo S. Influence of probenecid on pharmacokinetics of cefaclor. Chinese Journal Of Clinical Pharmacology and Therapeutics 7 (2002) 130-133