Proteasome Inhibitors in Myocardial Ischemia, Some Concerns

Annals of Thoracic Surgery

Volumn 85, Issue 4, 2008, Pages 1503-1504

  Powell, Saul R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; LACTACYSTIN BETA LACTONE; PROTEASOME INHIBITOR;

APOPTOSIS; CARDIOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HUMAN; LETTER; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACETYLCYSTEINE; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MICE; MYOCARDIAL ISCHEMIA; NF-KAPPA B; OXIDATION-REDUCTION; PROTEASOME ENDOPEPTIDASE COMPLEX; REPERFUSION INJURY; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 40749104854     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2007.10.049     Document Type: Letter

References (8)

1. Stansfield W.E., Moss N.C., Willis M.S., Tang R., and Selzman C. Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury. Ann Thorac Surg 84 (2007) 120-125
2. Powell S.R. The ubiquitin proteasome system in cardiac physiology and pathology. Am J Physiol Heart Circ Physiol 291 (2006) 1-19
3. Zollner T.M., Podda M., Pien C., Elliott P.J., Kaufmann R., and Boehncke W.H. Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model. J Clin Invest 109 (2002) 671-679
4. Powell S.R., Davies K.J.A., and Divald A. Optimal determination of heart tissue 26S proteasome activity requires maximal stimulating concentrations of ATP. J Mol Cell Cardiol 42 (2007) 265-269
5. Powell S.R., Wang P., Katzeff H.L., et al. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function. Essential role of the proteasome. Antioxid Redox Signal 7 (2005) 538-5
6. Powell S.R., Gurzenda E.M., Mantell L.L., Teichberg S., and Maulik D. Association of increased ubiquinated proteins with cardiac apoptosis. Antioxid Redox Signal 2 (2000) 103-112
7. Cai Z., and Semenza G.L. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circ Res 97 (2005) 1351-1359
8. Voortman J., and Giaccone G. Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report. BMC Cancer 6 (2006) 129