Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols-A proof-of-concept study

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 1922-1925

  Steiner, Andreas J ^a   Stütz, Arnold E ^a   Wrodnigg, Tanja M ^a   Tarling, Chris A ^b   Withers, Stephen G ^b   Hermetter, Albin ^a   Schmidinger, Hannes ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Glycosidase inhibitor; Iminoalditol; Iminosugar chip; Immobilisation

Indexed keywords

ALDITOL; BETA GLUCOSIDASE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; IMINOSUGAR; SILICON;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; ENZYME ANALYSIS; ENZYME INHIBITOR INTERACTION; MICROARRAY ANALYSIS; NONHUMAN; RHIZOBIUM;

ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; IMINO SUGARS; MAGNETIC RESONANCE SPECTROSCOPY; MICROARRAY ANALYSIS; MOLECULAR STRUCTURE; RHIZOBIUM;

EID: 40749102868     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.124     Document Type: Article

References (26)

1. For example: Iminosugars: From Synthesis to Therapeutic Applications, Compain, P.; Martin, O., Eds.; Wiley-VCH: Weinheim, 2008.
2. Martin O.R., and Compain P. Curr. Top. Med. Chem. 3 (2003) 471
3. Asano N., Nash R.J., Molyneux R.J., and Fleet G.W.J. Tetrahedron: Asymmetry 11 (2000) 4113
4. Wrodnigg T.M. In: Schmid W., and Stütz A.E. (Eds). Timely Research Perspectives in Carbohydrate Chemistry (1999), Springer, Vienna 43
5. Vasella A.T. Angew. Chem., Int. Ed. (1999-) 38 (1999) 750
6. Iminosugars as Glycosidase Inhibitors, Stütz, A. E., Ed.; Wiley-VCH: Weinheim, 1999.
7. Bols M. Acc. Chem. Res. 31 (1998) 1
8. Legler G. Adv. Carbohydr. Chem. Biochem. 48 (1990) 319
9. Spiro R.G. In: Ernst B., Hart G.W., and Sinay P. (Eds). Carbohydrates in Chemistry and Biology Vol. 3 (2000), Wiley-VCH, Weinheim 65
10. Elbein A.D., and Molyneux R.J. In: Stütz A.E. (Ed). Iminosugars as Glycosidase Inhibitors (1999), WILEY-VCH, Weinheim 216
11. ® by Bayer.
12. Butters T.D. Expert Opin. Pharmacother. 8 (2007) 427
13. Simmonds M.S.J., and Porter E.A. In: Stütz A.E. (Ed). Iminosugars as Glycosidase Inhibitors (1999), WILEY-VCH, Weinheim 8
14. Hermetter A., Scholze H., Stütz A.E., Withers S.G., and Wrodnigg T.M. Bioorg. Med. Chem. Lett. 11 (2001) 1339
15. Culf A.S., Cuperlovic-Culf M., and Ouellette R.J. OMICS 10 (2006) 289
16. Horlacher T., and Seeberger P.H. Biospektrum 12 (2006) 626
17. Seibel J., Hellmuth H., Hofer B., Kicinska A.-M., and Schmalbruch B. Chembiochem 7 (2006) 310
18. Lee M.-R., Par S., and Shin I. Bioorg. Med. Chem. Lett. 16 (2006) 5132
19. de Paz J.L., and Seeberger P.H. QSAR Comb. Sci. 25 (2006) 1027
20. Susani-Etzerodt H., Birner-Gruenberger R., and Hermetter A. Chembiochem 7 (2006) 527
21. Wrodnigg T.M., Stütz A.E., Tarling C.A., and Withers S.G. Carbohydr. Res. 341 (2006) 1717
22. Steiner A.J., Stütz A.E., Tarling C.A., Withers S.G., and Wrodnigg T.M. Carbohydr. Res. 342 (2007) 1850
23. 10S 719.94, found 720.415.
24. 11S 735.85, found 736.402.
25. 11S 735.85, found 736.402.
26. em: 685 nm; exposure time 3 s, sensitivity: high dynamic range.