Practical usage of O'Brien's OLS and GLS statistics in clinical trials

Pharmaceutical Statistics

Volumn 7, Issue 1, 2008, Pages 53-68

  Dallow, Nigel S ^a   Leonov, Sergei L ^b   Roger, James H ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Adjustment for covariates; GLS test; Multiple endpoints; O'Brien's OLS test; Operational effect size; Sample size

Indexed keywords

MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; BIOSTATISTICS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; COMPUTER PROGRAM; CORRELATION ANALYSIS; EFFECT SIZE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; LUNG BIOPSY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL COMPUTING; MONTE CARLO METHOD; MULTIVARIATE ANALYSIS; PROTEIN EXPRESSION; SAMPLE SIZE; SIMULATION; STATISTICAL ANALYSIS; TREATMENT RESPONSE;

BIOLOGICAL MARKERS; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; MODELS, STATISTICAL; MONTE CARLO METHOD; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SOFTWARE; TREATMENT OUTCOME;

EID: 40749099822     PISSN: 15391604     EISSN: 15391612     Source Type: Journal    
DOI: 10.1002/pst.268     Document Type: Article

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