Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14

Respirology

Volumn 13, Issue 2, 2008, Pages 215-220

  Inoue, Daisuke ^a   Kubo, Hiroshi ^a   Sasaki, Takahiko ^a   Yasuda, Hiroyasu ^a   Numasaki, Muneo ^a   Sasaki, Hidetada ^a   Yamaya, Mutsuo ^a  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Asthma; Erythromycin; Mucin; p44 42 MAPK; Rhinovirus

Indexed keywords

ERYTHROMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 3; MUCIN 5AC;

AIRWAY; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMMON COLD; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; RHINOVIRUS; RHINOVIRUS 14; TRACHEA MUCOSA; VIRUS CELL INTERACTION;

AGED; CELL CULTURE TECHNIQUES; COMMON COLD; EPITHELIAL CELLS; ERYTHROMYCIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; MALE; MIDDLE AGED; MUCINS; PROTEIN SYNTHESIS INHIBITORS; RNA, MESSENGER; TRACHEA;

EID: 40749093669     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2007.01227.x     Document Type: Article

References (23)

1. Rogers D. The airway goblet cells. Int. J. Biochem. Cell Biol. 2002 35 : 1 6.
2. Williams OW, Sharafkhaneh A, Kim V, Dickey BF, Evans CM. Airway mucus: from production to secretion. Am. J. Respir. Cell Mol. Biol. 2006 34 : 527 36.
3. Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus. Variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem. J. 2002 361 : 537 46.
4. Sheehan JK. Physical characterization of a low-charged glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucus plug. Biochem. J. 1999 338 : 507 13.
5. Imamura Y, Yanagihara K, Mizuta Y, Seki M, Ohno H et al. Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 cells. Antimicrob. Agents Chemother. 2004 48 : 3457 61.
6. Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am. J. Respir. Crit. Care Med. 2003 168 : 581 7.
7. Kaneko Y, Yanagihara K, Seki M, Kuroki M, Miyazaki Y et al. Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2003 285 : L847 53.
8. Inoue D, Yamaya M, Sasaki T, Hosoda M, Kubo H et al. Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells. Respir. Physiol. Neurobiol. 2006 154 : 484 99.
9. Terajima M, Yamaya M, Sekizawa K, Okinaga S, Suzuki T et al. Rhinovirus infection of primary cultures of human tracheal epithelium: role of ICAM-1 and IL-1beta. Am. J. Physiol. 1997 273 : L749 59.
10. Yamaya M, Sekizawa K, Suzuki T, Yamada N, Furukawa M et al. Infection of human respiratory submucosal glands with rhinovirus: effects on cytokine and ICAM-1 production. Am. J. Physiol. 1999 277 : L362 71.
11. Numazaki Y, Oshima T, Ohmi A, Tanaka A, Oizumi Y et al. A microplate method for isolation of viruses from infants and children with acute respiratory infections. Microbiol. Immunol. 1987 31 : 1085 95.
12. Suzuki T, Yamaya M, Sekizawa K, Hosoda M, Yamada N et al. Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001 280 : L1115 27.
13. Suzuki T, Yamaya M, Sekizawa K, Hosoda M, Yamada N et al. Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells. Am. J. Respir. Crit. Care Med. 2002 165 : 1113 8.
14. Inoue D, Numasaki M, Watanabe M, Kubo H, Sasaki T et al. IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway. Biochem. Biophys. Res. Commun. 2006 347 : 852 8.
15. Martell M, Gomez J, Esteban JI, Sauleda S, Quer J et al. High-throughput real-time reverse transcription-PCR quantitation of hepatitis C virus RNA. J. Clin. Microbiol. 1999 37 : 327 32.
16. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res. 1996 6 : 986 94.
17. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF et al. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J. Immunol. 2000 164 : 1546 52.
18. Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am. J. Respir. Crit. Care Med. 2001 163 : 517 23.
19. Finkbeiner WE, Basbaum CB. Monoclonal antibodies directed against human airway secretions. Localization and characterization of antigens. Am. J. Pathol. 1988 131 : 290 7.
20. Takeyama K, Dabbagh K, Lee HM, Agusti C, Lausier JA et al. Epidermal growth factor system regulates mucin production in airways. Proc. Natl. Acad. Sci. USA 1999 96 : 3081 6.
21. Kim DY, Takeuchi K, Ishinaga H, Kishioka C, Suzuki S et al. Roxithromycin suppresses mucin gene expression in epithelial cells. Pharmacology 2004 72 : 6 11.
22. Shinkai M, Foster GH, Rubin BK. Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006 290 : L75 85.
23. Shinkai M, Tamaoki J, Kobayashi H, Kanoh S, Motoyoshi K et al. Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppression. Antimicrob. Agents Chemother. 2006 50 : 1738 44.