Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2167-2171

  Douglass, James G ^a   deCamp, J Bryan ^a   Fulcher, Emilee H ^a   Jones, William ^a   Mahanty, Sanjoy ^a   Morgan, Anna ^a   Smirnov, Dima ^a   Boyer, José L ^a   Watson, Paul S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adenosine derivatives; P2Y12 antagonists; Platelet aggregation assay

Indexed keywords

ADENOSINE DERIVATIVE; PURINERGIC P2Y RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR BLOCKING; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; PLATELET AGGREGATION; RECEPTORS, PURINERGIC P2;

EID: 40749090353     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.038     Document Type: Article

References (11)

1. Defreyn G., Gachet C., Savi P., Driot F., Cazenave J.P., and Maffrand J.P. Thromb. Haemost. 65 (1991) 186
2. Schroer K. Platelets 4 (1993) 252
3. Gent M. The Lancet 348 (1996) 1329
4. Nguyen T.A., Diodati J.G., and Pharand C. J. Am. Coll. Cardiol. 45 (2005) 1157
5. Yende S., and Wunderink R.G. Crit. Care Med. 29 (2001) 2271
6. van Giezen J.J., and Humphries R.G. Semin. Thromb. Hemost. 31 (2005) 195
7. Springthorpe B., Bailey A., Barton P., Birkinshaw T.N., Bonnert R.V., Brown R.C., Chapman D., Dixon J., Guile S.D., Humphries R.G., Hunt S.F., Ince F., Ingall A.H., Kirk I.P., Leeson P.D., Leff P., Lewis R.J., Martin B.P., McGinnity D.F., Mortimore M.P., Paine S.W., Pairadaudeau G., Patel A., Rigby A.J., Riley R.J., Teobald B.J., Tomlinson W., Webborn P.J.H., and Willis P.A. Bioorg. Med. Chem. Lett. 17 (2007) 6013
8. Wang Y.X., Vincelette J., da Cunha V., Martin-McNulty B., Mallari C., Fitch R.M., Alexander S., Islam I., Buckman B.O., Yuan S., Post J.M., Subramanyam B., Vergona R., Sullivan M.E., Dole W.P., Morser J., and Bryant J. Thromb. Haemost. 97 (2007) 847
9. Scarborough R.M., Laibelman A.M., Clizbe L.A., Fretto L.J., Conley P.B., Reynolds E., Sedlock D.M., and Jantzen H. Bioorg. Med. Chem. Lett. 11 (2001) 1805
10. Douglass J.G., Patel R.I., Yerxa B.R., Shaver S.S., Watson P.S., Bednarski K., Plourde R., Redick C.C., Brubaker K., Jones A.C., and Boyer J.L. J. Med. Chem. 51 (2008) 1007
11. Watson, P. S.; Douglass, J. G.; Suchozak, B.; Pandiaraju, S.; Dixon, C. E.; Levin, D. U.S. Patent Application 0234976 AI, 2006.