Titanium tetraiodide promoted reductive opening of 2-(1-benzyloxyiminoethyl)aziridines, leading to aza-aldol reaction

Heterocycles

Volumn 74, Issue C, 2007, Pages 177-183

  Shimizu, Makoto ^a   Nishiura, Shuji ^a   Hachiya, Iwao ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 40749084043     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-07-s(w)43     Document Type: Article

References (16)

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3. The starting 2-(1-benzyloxyiminoethyl)aziridine (2) was prepared as follows. Methyl vinyl ketone was transformed into the O-benzyl oxime as a mixture of (E)- and (Z)-isomers under standered conditions. The isomers were readily separated by flash silica gel column chromatography. Each isomer was subjected to the Evans aziridine formation to give (E)- and (Z)-2. For the formation of aziridines, see
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