Development of a simplified assay for determination of the antimineralocorticoid activity of compounds dosed in rats

Journal of Pharmacological and Toxicological Methods

Volumn 57, Issue 2, 2008, Pages 155-160

  Brandish, Philip E ^a   Chen, Hongxing ^a   Szczerba, Peter ^a   Hershey, James C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aldosterone; Antimineralocorticoid; Diuresis; Method; Mineralocorticoid; Natriuresis; Rat

Indexed keywords

2 (DIPHENYLMETHYL) 1 (1 PHENYLETHYL) 1H IMIDAZOLE; ALDOSTERONE; AMILORIDE; EPLERENONE; HYDROCHLOROTHIAZIDE; IMIDAZOLE DERIVATIVE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; POTASSIUM; SODIUM; SODIUM CHLORIDE; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ADRENALECTOMY; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CONTROLLED STUDY; MALE; NONHUMAN; POTASSIUM EXCRETION; POTASSIUM URINE LEVEL; RAT; RECEPTOR BLOCKING; SODIUM EXCRETION; SODIUM URINE LEVEL; URINARY EXCRETION;

ANIMALIA; RATTUS;

EID: 40649125729     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2008.01.002     Document Type: Article

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