Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation

Free Radical Research

Volumn 42, Issue 1, 2008, Pages 70-81

  Alegria, Antonio E ^a   Sanchez Cruz, Pedro ^a   Kumar, Ajay ^a   Garcia, Carmelo ^a   Gonzalez, Fernando A ^b   Orellano, Aimee ^b   Zayas, Beatriz ^c   Gordaliza, Marina ^d  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO RIO PIEDRAS   (Puerto Rico)

^c UNIVERSIDAD METROPOLITANA   (Puerto Rico)

^d UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

BSA; BSA covalent binding; Cyclolignanic quinine; Glutathione adduct; Glutathione oxidation; Mg+2; Semiquinone; Topoisomerase II

Indexed keywords

7 ACETYL 3',4' DIDEMETHOXY 3',4' DIOXOPODOPHYLLOTOXIN; BOVINE SERUM ALBUMIN; CARBON; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GLUTATHIONE; MAGNESIUM CHLORIDE; MAGNESIUM ION; PODOPHYLLOTOXIN DERIVATIVE; QUINONE DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DENSITY FUNCTIONAL THEORY; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OXIDATION;

ANTINEOPLASTIC AGENTS; BENZOQUINONES; CATIONS, DIVALENT; CHELATING AGENTS; DNA TOPOISOMERASES, TYPE II; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; ETOPOSIDE; GLUTATHIONE; MAGNESIUM CHLORIDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PODOPHYLLOTOXIN; PROTEIN BINDING; QUINONES; SERUM ALBUMIN, BOVINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS;

EID: 40649120539     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760701790671     Document Type: Article

References (40)