Rolofylline (KW-3902): A new adenosine A1-receptor antagonist for acute congestive heart failure

Future Cardiology

Volumn 4, Issue 2, 2008, Pages 117-123

  Chaparro, Sandra ^a   Dittrich, Howard C ^b   Tang, W H Wilson ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NONE   (United States)

Author keywords

Adenosine A1 receptor antagonist; Cardiorenal syndrome; Heart failure; KW 3902; Natriuresis; Renal function; Rolofylline

Indexed keywords

1 [3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL)ACRYLOYL]PIPERIDINE 2 ACETIC ACID; 3 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)BICYCLO[2.2.2]OCTAN 1 YL]PROPIONIC ACID; 8 (2 NOR 1 ADAMANTYL) 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ANTIBIOTIC AGENT; CARBOPLATIN; CISPLATIN; CYTOCHROME P450 3A4; DIURETIC AGENT; FUROSEMIDE; LIXIVAPTAN; LOOP DIURETIC AGENT; MK 7418; NAXIFYLLINE; PLACEBO; SLV 320; SODIUM; UNCLASSIFIED DRUG;

ACUTE HEART FAILURE; ARTERY CONSTRICTION; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DIURESIS; DRUG DOSE ESCALATION; DRUG DOSE REGIMEN; DRUG METABOLISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG WITHDRAWAL; GLOMERULUS FILTRATION; HEART FAILURE; HEART PROARRHYTHMIA; HUMAN; KIDNEY BLOOD FLOW; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MONOTHERAPY; NATRIURESIS; NONHUMAN; PRIORITY JOURNAL; QT PROLONGATION; SEIZURE; SINGLE DRUG DOSE; SODIUM ABSORPTION; TREATMENT DURATION;

EID: 40649115008     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/14796678.4.2.117     Document Type: Article

References (15)