Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2343-2348

  Roessler, Christian G ^a   Hall, Branwen M ^a   Anderson, William J ^a   Ingram, Wendy M ^a   Roberts, Sue A ^a   Montfort, William R ^a   Cordes, Matthew H J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Conformational switching; Structural evolution; Transitive homology; X ray crystallography

Indexed keywords

DNA BINDING PROTEIN; PROTEIN PFL 6; PROTEIN XFASO 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; REPRESSOR PROTEIN; VIRUS PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; BACTERIOPHAGE LAMBDA; BACTERIOPHAGE P22; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DIMERIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FOLDING; SEQUENCE HOMOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 40649108103     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711589105     Document Type: Article

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