Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: An immunohistochemical study of premalignant and malignant lesions of the oral cavity

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Nomura, Hitomi ^a   Uzawa, Katsuhiro ^a,b   Ishigami, Takashi ^a   Kouzu, Yukinao ^a   Koike, Hirofumi ^a   Ogawara, Katsunori ^a   Siiba, Masashi ^a   Bukawa, Hiroki ^b   Yokoe, Hidetaka ^b   Kubosawa, Hitoshi ^c   Tanzawa, Hideki ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

^c CHIBA AOBA MUNICIPAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN CAPPING PROTEIN; BIOLOGICAL MARKER; GELSOLIN; MESSENGER RNA; ACTIN BINDING PROTEIN; CAPG PROTEIN, HUMAN; CARRIER PROTEIN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER STAGING; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FISHER EXACT TEST; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; PRECANCER; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TISSUE SECTION; UPREGULATION; BIOSYNTHESIS; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUTH; MOUTH TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CELL LINE, TUMOR; GELSOLIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MICROFILAMENT PROTEINS; MOUTH; MOUTH NEOPLASMS; NUCLEAR PROTEINS; PRECANCEROUS CONDITIONS;

EID: 40649107912     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-39     Document Type: Article

References (46)

1. Sudbo J Reith A: The evolution of predictive oncology and molecular-based therapy for oral cancer prevention. Int J Cancer 2005, 115:339-345. 10.1002/ijc.20896 15688375
2. Lippman SM Sudbo J Hong WK: Oral cancer prevention and the evolution of molecular-targeted drug development. J Clin Oncol 2005, 23:346-356. 10.1200/JCO.2005.09.128 15637397
3. Parkin DM Bray F Ferlay J Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 2005, 55:74-108. 15761078
4. La Vecchia C Lucchini F Negri E Levi F: Trends in oral cancer mortality in Europe. Oral Oncol 2004, 40:433-439. 10.1016/ j.oraloncology.2003.09.013 14969823
5. Chuthapisith S Layfield R Kerr ID Eremin O: Principles of proteomics and its applications in cancer. Surgeon 2007, 5:14-22. 17313124
6. Cho WC: Contribution of oncoproteomics to cancer biomarker discovery. Mol Cancer 2007, 6:25. 1852117 17407558 10.1186/1476-4598-6-25
7. Koike H Uzawa K Nakashima D Shimada K Kato Y Higo M Kouzu Y Endo Y Kasamatsu A Tanzawa H: Identification of differentially expressed proteins in oral squamous cell carcinoma using a global proteomic approach. Int J Oncol 2005, 27:59-67. 15942644
8. Nakashima D Uzawa K Kasamatsu A Koike H Endo Y Saito K Hashitani S Numata T Urade M Tanzawa H: Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands. Int J Cancer 2006, 118:704-713. 10.1002/ ijc.21318 16094606
9. Kasamatsu A Uzawa K Nakashima D Kouzu Y Endo Y Koike H Yokoe H Harada K Sato M Tanzawa H: A proteomics approach to characterizing human submandibular gland cell lines by fluorescent two-dimensional differential in-gel electrophoresis. Int J Mol Med 2006, 17:253-260. 16391823
10. Kato H Uzawa K Onda T Kato Y Saito K Nakashima D Ogawara K Bukawa H Yokoe H Tanzawa H: Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma. Int J Oncol 2006, 28:873-881. 16525636
11. Yu FX Johnston PA Sudhof TC Yin HL: GCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science 1990, 250:1413-1415. 10.1126/science.2255912 2255912
12. PAendergast GC Ziff EB: Mbh 1: a novel gelsolin/severin-related protein which binds actin in vitro and exhibits nuclear localization in vivo. EMBO J 1991, 10:757-766. 452713 1849072
13. Dabiri GA Young CL Rosenbloom J Southwick FS: Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. J Biol Chem 1992, 267:16545-16552. 1322908
14. Pollard TD Borisy GG: Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003, 112:453-465. 10.1016/ S0092-8674(03)00120-X 12600310
15. Welch MD Mullins RD: Cellular control of actin nucleation. Annu Rev Cell Dev Biol 2002, 18:247-288. 10.1146/annurev.cellbio.18.040202.112133 12142287
16. Janmey PA: The cytoskeleton andCcell signaling: component localization and mechanical coupling. Physiol Rev 1998, 73(3):763-781. 9674694
17. Maruta H He H Tikoo A Vuong T Nur-E-Kamal M: G proteins, phosphoinositides, and actin-cytoskeleton in the control of cancer growth. Microsc Res Tech 1999, 47:61-66. 10.1002/ (SICI)1097-0029(19991001)47:1<61::AID-JEMT6>3.0.CO;2-Y 10506762
18. Janmey A Paul: Medical aspects of the actin cytoskeleton. Curr Opin Cell Biol 1995, 7:111-117. 10.1016/0955-0674(95)80052-2 7755982
19. Rao J Li N: Microfilament actin remodeling as a potential target for cancer drug development. Curr Cancer Drug Targets 2004, 4:345-354. 10.2174/1568009043332998 15180500
20. Primer3 http://www-genome.wi.mit.edu/cgi-bin/primer/primer3_www.cgi
21. Johnston PA Yu FX Reynolds GA Yin HL Moomaw CR Slaughter CA Südhof TC: Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes. J Biol Chem 1990, 265:17946-17952. 2211671
22. Kassis J Lauffenburger DA Turner T Wells A: Tumor invasion as dysregulated cell motility. Semin Cancer Biol 2001, 11:105-117. 10.1006/ scbi.2000.0362 11322830
23. Yamazaki D Kurisu S Takenawa T: Regulation of cancer cell motility through actin reorganization. Cancer Sci 2005, 96:379-386. 10.1111/ j.1349-7006.2005.00062.x 16053508
24. Kikuchi S Yamada D Fukami T Masuda M Sakurai-Yageta M Williams YN Maruyama T Asamura H Matsuno Y Onizuka M Murakami Y; Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer. Clin Cancer Res 2005, 11:2954-2961. 10.1158/ 1078-0432.CCR-04-2206 15837747
25. Yoder BJ Tso E Skacel M Pettay J Tarr S Budd T Tubbs RR Adams JC Hicks DG: The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course. Clin Cancer Res 2005, 11:186-192. 15671545
26. Honda K Yamada T Hayashida Y Idogawa M Sato S Hasegawa F Ino Y Ono M Hirohashi S: Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology 2005, 128:51-62. 10.1053/j.gastro.2004.10.004 15633123
27. Dunn TA Chen S Faith DA Hicks JL Platz EA Chen Y Ewing CM Sauvageot J Isaacs WB De Marzo AM Luo J: A novel role of myosin VI in human prostate cancer. Am J Pathol 2006, 169:1843-1854. 1780223 17071605 10.2353/ ajpath.2006.060316
28. Kobayashi H Sagara J Kurita H Morifuji M Ohishi M Kurashina K Taniguchi S: Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma. Clin Cancer Res 2004, 10:572-580. 10.1158/1078-0432.CCR-1323-03 14760079
29. Sun HQ Yamamoto M Mejillano M Yin HL: Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 1999, 274:33179-33182. 10.1074/ jbc.274.47.33179 10559185
30. Silacci P Mazzolai L Gauci C Stergiopulos N Yin HL Hayoz D: Gelsolin superfamily proteins: Key regulators of cellular functions. Cell Mol Life Sci 2004, 61:2614-2623. 10.1007/s00018-004-4225-6 15526166
31. McGough AM Staiger CJ Min JK Simonetti KD: The gelsolin family of actin regulatory proteins: Modular structures, versatile functions. FEBS Lett 2003, 552:75-81. 10.1016/S0014-5793(03)00932-3 14527663
32. Yang J Ramnath N Moysich KB Asch HL Swede H Alrawi SJ Huberman J Geradts J Brooks JS Tan D: Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer 2006, 6:203. 1555597 16882345 10.1186/1471-2407-6-203
33. Winston JS Asch HL Zhang PJ Edge SB Hyland A Asch BB: Downregulation of gelsolin correlates with the progression to breast carcinoma. Breast Cancer Res Treat 2001, 65:11-21. 10.1023/A:1006446108411 11245335
34. Noske A Denkert C Schober H Sers C Zhumabayeva B Weichert W Dietel M Wiechen K: Loss of gelsolin expression in human ovarian carcinomas. Eur J Cancer 2005, 41:461-469. 10.1016/j.ejca.2004.10.025 15691647
35. Shieh DB Chen IW Wei TY Shao CY Chang HJ Chung CH Wong TY Jin YT: Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implications. Oral Oncol 2006, 42:599-606. 10.1016/ j.oraloncology.2005.10.021 16753328
36. Pellieux C Desgeorges A Pigeon CH Chambaz C Yin H Hayoz D Silacci P: CapG, a gelsolin family protein modulating protective effects of unidirectional shear stress. J Biol Chem 2003, 278(31):29136-29144. Epub 2003 May 17. 10.1074/jbc.M300598200 12754261
37. Sun HQ Kwiatkowska K Wooten DC Yin HL: Effects of CapG overexpression on agonist-induced motility and second messenger generation. J Cell Biol 1995, 129(1):147-156. 10.1083/jcb.129.1.147 7698981
38. Watari A Takaki K Higashiyama S Li Y Satomi Y Takao T Tanemura A Yamaguchi Y Katayama I Shimakage M Miyashiro I Takami K Kodama K Yutsudo M: Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene. CapG Oncogene 2006, 25:7373-7380. 10.1038/sj.onc.1209732 16767159
39. Bahassi el M Karyala S Tomlinson CR Sartor MA Medvedovic M Hennigan RF: Critical regulation of genes for tumor cell migration by AP-1. Clin Exp Metastasis 2004, 21:293-304. 10.1023/B:CLIN.0000046132.46946.dd 15554385
40. De Corte V Van Impe K Bruyneel E Boucherie C Mareel M Vandekerckhove J Gettemans J: Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion. J Cell Sci 2004, 117:5283-5292. 10.1242/jcs.01410 15454578
41. Van den Abbeele A De Corte V Van Impe K Bruyneel E Boucherie C Bracke M Vandekerckhove J Gettemans J: Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro. Cancer Lett 2007, 255:57-70. 10.1016/j.canlet.2007.03.023 17493746
42. Thompson CC Ashcroft FJ Patel S Saraga G Vimalachandran D Prime W Campbell F Dodson A Jenkins RE Lemoine NR Crnogorac-Jurcevic T Yin HL Costello El Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut 2007, 56:95-106. 10.1136/gut.2005.083691 16847067
43. Van Ginkel PR Gee RL Walker TM Hu DN Heizmann CW Polans AS: The identification and differential expression of calcium-binding proteins associated with ocular melanoma. Biochim Biophys Acta 1998, 1448:290-297. 10.1016/S0167-4889(98)00133-5 9920419
44. Lal A Lash AE Altschul SF Velculescu V Zhang L McLendon RE Marra MA Prange C Morin PJ Polyak K Papadopoulos N Vogelstein B Kinzler KW Strausberg RL Riggins GJ: A public database for gene expression in human cancers. Cancer Res 1999, 59:5403-5407. 10554005
45. Mithani SK Mydlarz WK Grumbine FL Smith IM Califano JA: Molecular genetics of premalignant oral lesions. Oral Dis 2007, 13:126-133. 10.1111/j.1601-0825.2006.01349.x 17305612
46. Califano J Westra WH Meininger G Corio R Koch WM Sidransky D: Genetic progression and clonal relationship of recurrent premalignant head and neck lesions. Clin Cancer Res 2000, 6:347-352. 10690509