The absorption, tissue distribution and excretion of enteraly administered α-ketoglutarate in rats

Journal of Animal Physiology and Animal Nutrition

Volumn 92, Issue 2, 2008, Pages 182-189

  Filip, R ^a,b   Pierzynowski, S G ^a  

^a LUND UNIVERSITY   (Sweden)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

14C; Absorption; Excretion; Rat; ketoglutarate

Indexed keywords

RATTUS;

EID: 40649103482     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2007.00725.x     Document Type: Article

References (29)

1. Aussel, C. ; Coudray‐Lucas, C. ; Lasnier, E. ; Cynober, L. ; Ekindjan, O. G., 1996: α ‐ketoglutarate uptake in human fibroblasts. Cell Biology International 20, 359–363.
2. Cynober, L. ; Coudray‐Lucas, C. ; De Bandt, J. P. ; Guechot, J. ; Aussel, C., Salvucci, M., Giboudeau, I., 1990: Action of ornithine α ‐ketoglutarate, ornithine hydrochloride and calcium α ‐ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects. Journal of the American College of Nutrition 9, 2–12.
3. Dabek, M. ; Kruszewska, D. ; Filip, R. ; Hotowy, A. ; Pierzynowski, Ł. ; Wojtasz‐Pająk, A. ; Szymczyk, S. ; Valverde‐Piedra, J. L. ; Werpachowska, E. ; Pierzynowski, S. G., 2005: α ‐ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics. Journal of Animal Physiology and Animal Nutrition 89, 419–426.
4. Darmaun, D., 1993: Role of the small intestine in glutamine metabolism. Clinical Nutrition 12, 50–51.
5. Diegelmann, R. F., 2003: Analysis of collagen synthesis. Methods of Molelular Medicine 78, 349–358.
6. Filip, R. S. ; Pierzynowski, S. G. ; Lindegard, B. ; Wernerman, J. ; Haratym‐Maj, A. ; Podgurniak, M., 2006: Alpha‐ketoglutarate decreases serum levels of C‐terminal cross‐linking telopeptide of type I collagen (CTX) in postmenopausal women with Osteopenia: six‐‐month study. International Journal of Vitamin and Nutrition Research 136, 2779–2784.
7. Fläring, U. B. ; Rooyackers, O. E. ; Wernerman, J. ; Hammarqvist, F., 2003: Glutamine attenuates posttraumatic glutathione depletion in human muscle. Clinical Science 104, 275–282.
8. Hammerqvist, F. ; Wernerman, J. ; Ali, R. ; Von Der Decken, A. ; Vinnars E., 1989: Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis and improves nitrogen balance. Annals of Surgery 209, 455–461.
9. Harrison, A. P. ; Tygesen, M. P. ; Sawa‐Wojtanowicz, B. ; Husted, S. ; Tatara, M. R., 2004: α ‐ketoglutarate treatment early in postnatal life improves bone density in lambs at slaughter. Bone 35, 204–209.
10. Junghans, P. ; Derno, M. ; Pierzynowski, S. ; Heling, U. ; Souffrant, W. B., 2003: Utilisation of α ‐Ketoglutarate (AKG) in Young Growing Pigs after Intra‐Venous and Intra‐Duodenal Administration. The EAAP‐Symposium (European Association of Animal Production) on Energy and Protein Metabolism and Nutrition, Rostock‐Warnemunde, Germany, September, pp. 521–523.
11. Kristensen, N. B. ; Jungvid, H. ; Fernandez, J. A. ; Pierzynowski, S. G., 2002: Absorption and metabolism of α ‐ketoglutarate in growing pigs. Journal of Animal Physiology and Animal Nutrition 86, 239–245.
12. Krzymowski, T., 1973: Physiology of Animals. Panstwowe Wydawnictwo Rolne i Lesne, Warsaw, Poland.
13. MacLennan, P. A. ; Brown, R. A. ; Rennie, M. J., 1987: A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. Federation of European Biochemical Societies Letters 215, 187–191.
14. MacLennan, P. A. ; Smith, K. ; Weryk, B. ; Watt, P. W. ; Rennie, M. J., 1988: Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle. Federation of European Biochemical Societies Letters 237, 133–136.
15. Mitruka, B. M. ; Martinka, H. ; Rawnsley, M. ; 1977: Clinical Biochemical and Haematological Reference Values in Normal Experimental Animals. Masson Publishing, New York, USA.
16. Radzki, R. P. ; Bienko, M. ; Puzio, I. ; Filip, R. ; Pierzynowski, S. G. ; Studzinski, T., 2002: The effect of alpha‐ ketoglutarate (AKG) on mineralization of femur in ovariectomized rats. Acta Orthopedica Scandinavica 73, 52.
17. Reeds, P. J. ; Burrin, D. G. ; Jahoor, F. ; Wykes, L. ; Henry, J. ; Frazer, E. M., 1996: Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs. American Journal of Physiology 270, 413–418.
18. Riedel, E. ; Hampl, H. ; Steudle, V. ; Nündel, M., 1996a: Calcium Alpha‐ketoglutarate administration to malnutritioned hemodialysis patients improves plasma arginine concentration. Mineral and Electrolyte Metabolism 22, 119–122.
19. Riedel, E. ; Nündel, M. ; Hampl, H., 1996b: α ‐ketoglutarate application in hemodialysis patients improves amino acid metabolism. Nephron 74, 261–265.
20. Stoll, B. ; McNelly, S. ; Buscher, H. P. ; Häussinger, D., 1991: Functional hepetocyte heterogenicity in glutamate, aspartate and α ‐ketoglutarate uptake: a histoautoradiographic study. Hepatology 13, 247–253.
21. Stoll, B. ; Burrin, D. G. ; Henry, J. ; Yu, H. ; Jahoor, F. ; Reeds P., 1999: Substrate oxidation by the portal drained viscera of fed piglets. American Journal of Physiology 277, 168–175.
22. Waterlow, J. C., 1984: Protein turnover with special reference to man. Quarterly Journal of Experimental Physiology 69, 409–438.
23. Waterlow, J. C. ; Garlick, P. J. ; Milward, D. J., 1978: Protein Turnover in Mammalian Tissues and in the Whole Body. Elsevier, Amsterdam, Holland.
24. Welborn, J. R. ; Shpun, S. ; Dantzler, W. H. ; Wright, S. H., 1998: Effect of α ‐ketoglutarate on organic anion transport in single rabbit renal proximal tubules. American Journal of Physiology 274, 165–174.
25. Welbourne, T. C. ; Balagura‐Baruch, S., 1972: Renal metabolism of glutamine in dogs during infusion of α ‐ketoglutaric acid. American Journal of Physiology 223, 663–666.
26. Wellbourne T. C., 1993: Alpha‐ketoglutarate, ornithine and growth hormone displace glutamine dependent ammoniagenesis and enhance renal base generation and function. Clinical Nutrition 12, 49–50.
27. Welle, S., 1999: Human Protein Metabolism. Springer‐ Verlag, New York, USA.
28. Wu, G. ; Thompson, J. R., 1990: The effect of glutamine on protein turnover in chick skeletal muscle in vitro. Biochemical Journal 265, 593–598.
29. Zhou, X. ; Thompson, J. R., 1997: Regulation of protein turnover by glutamine in heat shocked skeletal myotubes. Biochimica et Biophysica Acta 1357, 234–242.