Neural transdifferentiation of bone marrow stromal cells obtained by chemical agents is a short-time reversible phenomenon

Neuroscience Research

Volumn 60, Issue 3, 2008, Pages 275-280

  Zurita, Mercedes ^a   Bonilla, Celia ^a   Otero, Laura ^a   Aguayo, Concepción ^a   Vaquero, Jesús ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Bone marrow stromal cells; Neural transdifferentiation; Schwann cells; Stem cells

Indexed keywords

CHEMICAL AGENT;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; IMMUNOHISTOCHEMISTRY; NERVE CELL DIFFERENTIATION; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERMEDIATE FILAMENT PROTEINS; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; NEURONS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHWANN CELLS; SCIATIC NERVE; STROMAL CELLS; TUBULIN;

EID: 40649100070     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2007.11.006     Document Type: Article

References (22)

1. Bossolasco P., Cova L., Calzarossa C., Rimoldi S.G., Borsotti C., Deliliers G.L., Silani V., Soligo D., and Polli E. Neuro-glial differentiation of human bone marrow stem cells in vitro. Exp. Neurol. 193 (2005) 312-325
2. Brazelton T.R., RossI F.M., Keshet G.I., and Blau H.M. From marrow to brain: expression of neural phenotypes in adult mice. Science 290 (2000) 1775-1779
3. Chopp M., and Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 1 (2002) 92-100
4. Croft A.P., and Przyborski S.A. Formation of neuron by non-neural adult stem cells: potential mechanism implicates and artifact of growth in culture. Stem Cells 15 (2006) 1841-1851
5. Dezawa M., Kanno H., Hoshino M., Cho H., Matsumoto N., Itokazu Y., Tajima N., Yamada H., Sawada H., Ishikawa H., Mimura T., Kitada M., Suzuki Y., and Ide C. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J. Clin. Invest. 113 (2004) 1701-1710
6. Eglitis M.A., and Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4080-4085
7. Hofstetter C.P., Schwarz E.J., Hess D., Widenfalk J., El Manira A., Prockop D.J., and Olson L. Marrow stromal cells for, guiding strands in the injured spinal cord and promote recovery. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 2199-2204
8. Hung S., Cheng H., Pan C., Tsai M.J., Kao L., and Ma H. In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells 20 (2002) 522-529
9. Kohyama J., Abe H., Shimazaki T., Koizumi A., Nakashima K., Gojo S., Taga T., Okano H., Hata J., and Umezawa A. Brain from bone: efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent. Differentiation 68 (2001) 235-244
10. Liu Y., and Rao M.S. Transdifferentiation-fact or artifact. J. Cell. Biochem. 88 (2003) 29-40
11. Lu P., Blesch A., and Tuszynski M.H. Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation or artefact?. J. Neurosci. Res. 77 (2004) 174-191
12. Mezey E., and Chandross K.J. Bone marrow: a possible alternative source of cells in the adult nervous system. Eur. J. Pharmacol. 405 (2000) 297-302
13. Mori T., Kiyono T., Imabayashi H., Takeda Y., Tsuchiya K., Miyoshi S., Makino H., Matsumoto K., Saito H., Ogawa S., Sakamoto M., Hata J., and Umezawa A. Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential. Mol. Cell. Biol. 25 (2005) 5183-5195
14. Prockop D.J. Marrow stromal cells for nonhematopoietic tissues. Science 276 (1997) 71-74
15. Sánchez-Ramos J., Song S., Cardozo-Pelaez F., Hazzi C., Stedeford T., Willing A., Freeman T.B., Saporta S., Janssen W., Patel N., Cooper D.R., and Sanberg P.R. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp. Neurol. 164 (2000) 247-256
16. Vaquero J., Zurita M., Oya S., and Santos M. Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration?. Neurosci. Lett. 398 (2006) 129-134
17. Vogel W., Grunebach F., Messam C.A., Kanz L., Brugger W., and Buhring H.J. Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells. Haematologica 88 (2003) 126-133
18. Woodbury D., Schwar E.J., Prockop D.J., and Black I.B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61 (2000) 364-370
19. Zurita M., Aguayo C., Oya S., and Vaquero J. Implication of neurotrophic factors in the neuronal transdifferentiation of adult mesenchymal stem cells. Mapfre Med. 18 (2007) 201-208 (in Spanish)
20. Zurita M., and Vaquero J. Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation. NeuroReport 15 (2004) 1105-1108
21. Zurita M., and Vaquero J. Bone marrow stromal cells can achieve cure of chronic paraplegic rats: functional and morphological outcome one year after transplantation. Neurosci. Lett. 402 (2006) 51-56
22. Zurita M., Vaquero J., Oya S., and Miguel M. Schwann cells induce neuronal differentiation of bone marrow stromal cells. NeuroReport 16 (2005) 505-508