Platelet larceny: Spurious hypoxaemia due to extreme thrombocytosis

European Respiratory Journal

Volumn 31, Issue 2, 2008, Pages 469-472

  Mehta, A ^a   Lichtin, A E ^a   Vigg, A ^a   Parambil, J G ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Extreme thrombocytosis; Polycythaemia vera; Spurious hypoxaemia

Indexed keywords

ERYTHROPOIETIN; HYDROXYUREA; POTASSIUM CYANIDE;

AGED; ANAMNESIS; ARTERIAL OXYGEN TENSION; ARTICLE; CASE REPORT; CLINICAL FEATURE; DIAGNOSTIC IMAGING; FEMALE; HUMAN; HYPOXEMIA; LEUKOCYTE COUNT; LEUKOCYTOSIS; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PULSE OXIMETRY; THROMBOCYTE COUNT; THROMBOCYTOSIS; TREATMENT OUTCOME; ANOXIA; BLOOD GAS ANALYSIS; FOLLOW UP; HOSPITALIZATION; METHODOLOGY; OXIMETRY; OXYGEN CONSUMPTION; PHYSIOLOGY; RISK ASSESSMENT;

AGED; ANOXIA; BLOOD GAS ANALYSIS; FEMALE; FOLLOW-UP STUDIES; HUMANS; OXIMETRY; OXYGEN CONSUMPTION; PHLEBOTOMY; PLATELET COUNT; POLYCYTHEMIA VERA; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; THROMBOCYTOSIS;

EID: 40649089109     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00039607     Document Type: Article

References (21)

1. Hess CE, Nichols AB, Hunt WB, Suratt PM. Pseudohypoxemia secondary to leukemia and thrombocytosis. N Engl J Med 1979; 301: 361-363.
2. Loke J, Duffy TP. Normal arterial oxygen saturation with the ear oximeter in patients with leukemia and leukocytosis. Cancer 1984; 53: 1767-1769.
3. Gorski TF, Ajemian M, Hussain E, et al. Correlation of pseudohypoxemia and leukocytosis in chronic lymphocytic leukemia. South Med J 1999; 92: 817-819.
4. Sacchetti A, Grynn J, Pope A, Vasso S. Leukocyte larceny: spurious hypoxemia confirmed with pulse oximetry. J Emerg Med 1990; 8: 567-569.
5. Mizock BA, Franklin C, Lindesmith P, Shah PC. Confirmation of spurious hypoxemia using continuous blood gas analysis in a patient with chronic myelogenous leukemia. Leuk Res 1995; 19: 1001-1004.
6. Fox MJ, Brody JS, Weintraub LR. Leukocyte larceny: a cause of spurious hypoxemia. Am J Med 1979; 67: 742-746.
7. Charoenratanakul S, Loasuthi K. Pseudohypoxemia in a patient with acute leukemia. Thorax 1997; 52: 394-395.
8. Jalavisto E. Oxygen consumption of blood and plasma and the percentage of reticulocytes. Acta Physiol Scand 1959; 46: 244-251.
9. Bird RM, Clements JA, Becker LM. The metabolism of leukocytes taken from peripheral blood of leukemic patients. Cancer 1951; 4: 1009-1014.
10. Onaka M. Über Oxydationen im Blut. [On oxidation in the blood.] Z Physiol Chem 1911; 71: 193-199.
11. Antognetti R, Fracchia P, Robustelli G. Behavior of oxygen consumption, anaerobic glycolysis, and blood platelets' enzyme activities in patients with essential thrombopenia. Haematologica 1963; 48: 930-936.
12. Kitchens CS, Newcomb TF. Human platelet respiration. J Appl Physiol 1968; 25: 581-585.
13. Holmsen H. Platelet metabolism and activation. Semin Hematol 1985; 22: 219-240.
14. Mürer EH, Hellem AJ, Rozenberg MC. Energy metabolism and platelet function. Scand J Clin Lab Invest 1967; 19: 280-282.
15. DeWardener HE, Young IM. Oxygen consumption of polycythemic blood in vitro with a note on the arterial oxygen saturation in primary polycythemia. Clin Sci 1951; 10: 497-510.
16. McMorrow RC, Mythen MG. Pulse oximetry. Curr Opin Crit Care 2006; 12: 269-271.
17. Akkerman JW, Gorter G, Soons H, Holmsen H. Close correlation between platelet responses and adenylate energy charge during transient substrate depletion. Biochim Biophys Acta 1983; 760: 34-41.
18. Schwarcz TH, Hogan LA, Endean ED, Roitman IT, Kazmers A, Hyde GL. Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia. J Vasc Surg 1993; 17: 518-523.
19. Dingli D, Utz JP, Krowka MJ, Oberg AL, Tefferi A. Unexplained pulmonary hypertension in chronic myeloproliferative disorders. Chest 2001; 120: 801-808.
20. Tzankov A, Krugmann J, Mikuz G. Glottis edema and interstitial pulmonary disease as a result of extramedullary hemopoiesis in polycythemia vera rubra causing asphyctic death. J Clin Pathol 2003; 56: 79.
21. V617F mutation screening and PRV-1 expression analysis in myeloproliferative disorders and secondary polycythemia. Br J Haematol 2005; 131: 166-171.