Methylene substitution at the α-β bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

Proteins: Structure, Function and Genetics

Volumn 71, Issue 1, 2008, Pages 308-319

  Kovári, Júlia ^a   Barabás, Orsolya ^a   Varga, Balázs ^a   Békési, Angéla ^a   Tölgyesi, Ferenc ^b   Fidy, Judit ^a,b   Nagy, József ^c   Vértessy, Beáta G ^c,d  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^d INSTITUTE OF ENZYMOLOGY   (Hungary)

Author keywords

Antibiotics; DNA repair; Drug design; Enzyme inhibitor; Metal cofactor; Nucleotide analogues; Phosphate chain conformation

Indexed keywords

CARBENE; DEOXYURIDINE PHOSPHATE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE INHIBITOR; ENZYME INHIBITOR; LIGAND; NUCLEOTIDE DERIVATIVE; PHOSPHATE; PHOSPHORUS; PROTEIN SUBUNIT; PYRUVATE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CALORIMETRY; CATALYSIS; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA MODIFICATION; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROLYSIS; ISOTHERM; LIGAND BINDING; PHOSPHORYLATION; PRIORITY JOURNAL; SUBSTITUTION REACTION; THREE DIMENSIONAL IMAGING;

BINDING SITES; ESCHERICHIA COLI PROTEINS; LIGANDS; PROTEIN BINDING; PYROPHOSPHATASES; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 40549141791     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21757     Document Type: Article

References (44)