Minimum requirements of hydrophobic and hydrophilic features in cationic peptide antibiotics (CPAs): Pharmacophore generation and validation with cationic steroid antibiotics (CSAs)

Journal of Molecular Modeling

Volumn 14, Issue 4, 2008, Pages 265-278

  Sundriyal, Sandeep ^a   Sharma, Rohit K ^a   Jain, Rahul ^a   Bharatam, Prasad V ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Amphiphiles; Catalyst; Cationic peptide antibiotics; Cationicsteroids antibiotics; HipHop; Minimum requirement; Pharmacophore generation

Indexed keywords

AMINO ACID; AMPHOPHILE; ANTIBIOTIC AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; CATIONIC STEROID ANTIBIOTIC; PEPTIDE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL STRAIN; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ESCHERICHIA COLI; HYDROPHILICITY; HYDROPHOBICITY; HYPOTHESIS; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; SCORING SYSTEM; STAPHYLOCOCCUS AUREUS; VALIDATION PROCESS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; COMPUTER SIMULATION; ESCHERICHIA COLI; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SOFTWARE; STAPHYLOCOCCUS AUREUS; STEROIDS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 40549118540     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-008-0268-1     Document Type: Article

References (44)