Enhancement of poly-3-hydroxybutyrate (PHB) productivity by the two-stage supplementation of carbon sources and continuous feeding of NH4Cl

Biotechnology and Bioprocess Engineering

Volumn 13, Issue 1, 2008, Pages 14-24

  Yeo, Joo Sang ^a   Park, Jae Yeon ^a   Yeom, Sung Ho ^b   Yoo, Young Je ^a  

^a Seoul National University   (South Korea)

^b Gangneung Wonju National University   (South Korea)

Author keywords

Biodegradable polymer; Gluconate; Glucose; Intracellular energetic; PHB; Two stage culture

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMMONIUM CHLORIDE; GLUCONIC ACID; GLUCOSE; POLY(3 HYDROXYBUTYRIC ACID); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; BIOTECHNOLOGICAL PROCEDURES; BIOTECHNOLOGICAL PRODUCTION; CARBON SOURCE; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE OPTIMIZATION; CUPRIAVIDUS NECATOR; GLUCOSE TRANSPORT; INTERMETHOD COMPARISON; NONHUMAN;

EID: 40549114304     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12257-007-0138-1     Document Type: Article

References (38)

1. Lee, Y. W., Y. J. Yoo, and J. W. Yang (1995) Optimization of two-stage continuous culture system for production of poly-β-hydroxybutyrate. Kor. J. Chem. Eng. 12: 481-484.
2. Kim, B. S., S. C. Lee, S. Y. Lee, H. N. Chang, Y. K. Chang, and S. I. Woo (1994) Production of poly(3-hydroxybutyric acid) by fed-batch culture of Alcaligenes eutrophus with glucose concentration control. Biotechnol. Bioeng. 43: 892-898.
3. 2 by high cell density autotrophic cultivation of Alcaligenes eutrophus. Biotechnol. Bioeng. 45: 268-275.
4. Park, T. J., J. P. Park, S. J. Lee, H. J. Hong, and S. Y, Lee (2006) Polyhydroxyalkanoate chip for the specific immobilization of recombinant proteins and its applications in immunodiagnostics. Biotechnol. Bioprocess Eng. 11: 173-177.
5. Shi, F., Z. Xu, and P. Cen (2006) Optimization of γ-polyglutamic acid production by Bacillus subtilis ZJU-7 using a surface-response methodology. Biotechnol. Bioprocess Eng. 11: 251-257.
6. Shang, L., D. D. Fan, M. I. Kim, J. D. R. Choi, and H. N. Chang (2007) Modeling of poly(3-hydroxybutyrate) production by high cell density fed-batch culture of Ralstonia eutropha. Biotechnol. Bioprocess Eng. 12: 417-423.
7. Dawes, E. A. and P. J. Senior (1973) The role and regulation of energy reserve polymers in microorganisms. Adv. Microbiol. Physiol. 10: 135-266.
8. Henderson, R. A. and C. W. Jones (1997) Physiology of poly-3-hydroxybutyrate (PHB) production by Alcaligenes eutrophus growing in continuous culture. Microbiology 143: 2361-2371.
9. Alderete, J. E., D. W. Karl, and C. H. Park (1993) Production of poly(hydroxybutyrate) homopolymer and copolymer from ethanol and propanol in a fed-batch culture. Biotechnol. Prog. 9: 520-525.
10. Braunegg, G., B. Sonnleitner, and R. M. Lafferty (1978) A rapid gas chromatographic method for the determination of poly-β-hydroxybutyric acid in microbial biomass. Eur. J. Appl. Microbiol. Biotechnol. 6: 29-37.
11. Sonnleitner, B., E. Heinzle, G. Braunegg, and R. M. Lafferty (1979) Formal kinetics of poly-β-hydroxybutyric acid (PHB) production in Alcaligenes eutrophus H16 and Mycoplana rubra R14 with respect to the dissolved oxygen tension in ammonium-limited batch cultures. Eur. J. Appl. Microbiol. Biotechnol. 7: 1-10.
12. Yamane, T. (1993) Yield of poly-D(-)-3-hydroxybutyrate from various carbon sources: A theoretical study. Biotechnol. Bioeng. 41: 165-170.
13. Leaf, T. A. and F. Srienc (1998) Metabolic modeling of polyhydroxybutyrate biosynthesis. Biotechnol. Bioeng. 57: 557-570.
14. Schlegel, H. G. and G. Gottschalk (1965) Verwertung von Glucose durch eine Mutante von Hydrogenomonas H16. Biochem. Z. 341: 249-259.
15. Bitar, A. and S. Underhill (1990) Effect of ammonium supplementation on production of poly-β-hydroxybutyric acid by Alcaligenes eutrophus in batch culture. Biotechnol. Lett. 12: 563-568.
16. Lee, Y. W. and Y. J. Yoo (1994) High cell density culture of Alcaligenes eutrophus and poly-β-hydroxybutyrate production by optimization of medium compositions. Kor. J. Appl. Microbiol. Biotechnol. 22: 401-406.
17. Srienc, F., B. Arnold, and J. E. Bailey (1984) Characterization of intracellular accumulation of poly-β-hydroxybutyrate (PHB) in individual cells of Alcaligenes eutrophus H16 by flow cytometry. Biotechnol. Bioeng. 26: 982-987.
18. Theobald, U., W. Mailinger, M. Reuss, and M. Rizzi (1993) In vivo analysis of glucose-induced fast changes in yeast adenine nucleotide pool applying a rapid sampling technique. Anal. Biochem. 214: 31-37.
19. Stocchi, V., L. Cucchiarini, M. Magnani, L. Chiarantini, P. Palma, and G. Crescentini (1985) Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells. Anal. Biochem. 146: 118-124.
20. Conway, T. (1992) The Entner-Doudoroff pathway: history, physiology and molecular biology. FEMS Microbiol. Rev. 103: 1-27.
21. Haywood, G. W., A. J. Anderson, L. Chu, and E. A. Dawes (1988) The role of NADH- and NADPH-linked acetoacetyl-CoA reductase in the poly-3-hydroxybutyrate synthesizing organism Alcaligenes eutrophus. FEMS Microbiol. Lett. 52: 259-264.
22. Gottschalk, G. (1986) Bacterial Metabolism. 2nd ed., Springer-Verlag Inc., New York, NY, USA.
23. Nelson, D. L. and M. M. Cox (2005) Principles of Biochemistry. pp. 1099. W.H. Freeman and Company, New York, NY, USA.
24. Nelson, D. L. and M. M. Cox (2005) Principles of Biochemistry. pp. 571. W.H. Freeman and Company, New York, NY, USA.
25. Nielsen, J. and J. Villadsen (1994) Bioreaction Engineering Principles. Plenum Press, New York, NY, USA.
26. Lee, I. Y., M. K. Kim, H. N. Chang, and Y. H. Park (1995) Regulation of poly-β-hydroxybutyrate biosynthesis by nicotinamide nucleotide in Alcaligenes eutrophus. FEMS Microbiol. Lett. 131: 35-39.
27. Anderson, A. J. and E. A. Dawes (1990) Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol. Rev. 54: 450-472.
28. Jung, Y. M. and Y. H. Lee (1997) Investigation of regulatory mechanism of flux of acetyl-CoA in Alcaligenes eutrophus using PHB-negative mutant and transformants harboring cloned phbCAB genes. J. Microbiol. Biotechnol. 7: 215-222.
29. Suzuki, T., T. Yamane, and S. Shimizu (1986) Mass production of poly-β-hydroxybutyric acid by fed-batch culture with controlled carbon/nitrogen feeding. Appl. Microbiol. Biotechnol. 24: 370-374.
30. Madigan, M. T. and J. M. Martinko (2006) Biology of Microorganisms. pp. 132. Pearson Prentice Hall, Upper Saddle River, NJ, USA.
31. Lee, J. N., H. D. Shin, and Y. H. Lee (2003) Metabolic engineering of pentose phosphate pathway in Ralstonia eutropha for enhanced biosynthesis of poly-β-hydroxybutyrate. Biotechnol. Prog. 19: 1444-1449.
32. Reddy, C. S. K., R. Ghai, Rashmi, and V. C. Kalia (2003) Polyhydroxyalkanoates: an overview. Bioresour. Technol. 87: 137-146.
33. Jung, Y. M., J. S. Park, and Y. H. Lee (2000) Metabolic engineering of Alcaligenes eutrophus through the transformation of cloned phbCAB genes for the investigation of the regulatory mechanism of polyhydroxyalkanoate biosynthesis. Enzyme Microb. Technol. 26: 201-208.
34. Anderson, A. J., D. R. Williams, B. Taidi, E. A. Dawes, and D. F. Ewing (1992) Studies on copolyester synthesis by Rhodococcus ruber and factors influencing the molecular mass of polyhydroxybytyrate accumulated by Methylobacterium extorquens and Alcaligenes eutrophus. FEMS Micobiol. Rev. 103: 93-102.
35. Shimizu, H., S. Tamura, S. Shioya, and K. I. Suga (1993) Kinetic study of poly-D(-)-3-hydroxybutyric acid (PHB) production and its molecular weight distribution control in a fed-batch culture of Alcaligenes eutrophus. J. Ferment. Bioeng. 76: 465-469.
36. Holmes, P. A. (1985) Applications of PHB: a microbially produced biodegradable thermoplastic. Phys. Technol. 16: 32-36.
37. Matin, A. (1978) Organic nutrition of chemolithotrophic bacteria. Ann. Rev. Microbiol. 32: 433-468.
38. Schobert, P. and B. Bowien (1984) Unusual C3 and C4 metabolism in the chemoautotroph Alcaligenes eutrophus. J. Bacteriol. 159: 167-172.