Targeted drug delivery to bone: Pharmacokinetic and pharmacological properties of acidic oligopeptide-tagged drugs

Current Drug Discovery Technologies

Volumn 5, Issue 1, 2008, Pages 39-48

  Takahashi Nishioka, Tatsuo ^a   Yokogawa, Koichi ^b   Tomatsu, Shunji ^c   Nomura, Masaaki ^a   Kobayashi, Shinjiro ^a   Miyamoto, Kenichi ^b  

^a HOKURIKU UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acidic oligopeptide; Drug delivery system; Estradiol; Hypophosphatasia; Levofloxacin; Osteomyelitis; Osteoporosis; Tissue nonspecific alkaline phosphatase

Indexed keywords

17 BETA ESTRADIOL 17 BETA SUCCINATE; 17 BETA ESTRADIOL 3 SUCCINATE; ALKALINE PHOSPHATASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; ESTER; ESTRADIOL; ESTROGEN; FOLINIC ACID; HEXAPEPTIDE; HYDROXYAPATITE; LEVOFLOXACIN; LEVOFLOXACIN 3 GLYCOLATE; METHOTREXATE; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; BIOLOGICAL ACTIVITY; BONE MARROW SUPPRESSION; BREAST CANCER; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CONTINUOUS INFUSION; DEBRIDEMENT; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HYDROLYSIS; DRUG MEGADOSE; DRUG RECEPTOR BINDING; DRUG RELEASE; DRUG SELECTIVITY; DRUG TARGETING; DRUG TISSUE LEVEL; ENDOMETRITIS; ENDOMETRIUM CANCER; ESTROGEN THERAPY; FEASIBILITY STUDY; HUMAN; IN VITRO STUDY; KIDNEY DISEASE; LIVER DISEASE; MUSCULOSKELETAL DISEASE; NONHUMAN; OSTEOMYELITIS; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; SKIN DISEASE; UNSPECIFIED SIDE EFFECT; UTERUS BLEEDING;

ACIDS; ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; DRUG DELIVERY SYSTEMS; ESTRADIOL; HUMANS; OFLOXACIN; OLIGOPEPTIDES; PHARMACEUTICAL PREPARATIONS;

EID: 40549112652     PISSN: 15701638     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016308783769405     Document Type: Review

References (74)