메뉴 건너뛰기




Volumn 47, Issue 10, 2008, Pages 3117-3130

Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; MATHEMATICAL MODELS; POLYPEPTIDES; PROTEINS; THREE DIMENSIONAL;

EID: 40549111917     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702321a     Document Type: Article
Times cited : (27)

References (59)
  • 2
    • 0024493978 scopus 로고
    • Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data
    • Zuiderweg, E. R., Nettesheim, D. G., Mollison, K. W., and Carter, G. W. (1989) Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data. Biochemistry 28, 172-185.
    • (1989) Biochemistry , vol.28 , pp. 172-185
    • Zuiderweg, E.R.1    Nettesheim, D.G.2    Mollison, K.W.3    Carter, G.W.4
  • 3
    • 0030999525 scopus 로고    scopus 로고
    • Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy
    • Zhang, X., Boyar, W., Toth, M. J., Wennogle, L., and Gonnella, N. C. (1997) Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy. Proteins 28, 261-267.
    • (1997) Proteins , vol.28 , pp. 261-267
    • Zhang, X.1    Boyar, W.2    Toth, M.J.3    Wennogle, L.4    Gonnella, N.C.5
  • 5
    • 0035800032 scopus 로고    scopus 로고
    • Advances in determination of a high-resoultion three-dimensional structure of rhodpsin, a model of G-protein-coupled receptors (GPCRs)
    • Teller, D. C., Okada, T., Behnke, C. A., Palczewski, K., and Stenkamp, R. E. (2001) Advances in determination of a high-resoultion three-dimensional structure of rhodpsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 40, 7761-7772.
    • (2001) Biochemistry , vol.40 , pp. 7761-7772
    • Teller, D.C.1    Okada, T.2    Behnke, C.A.3    Palczewski, K.4    Stenkamp, R.E.5
  • 7
    • 4344581120 scopus 로고    scopus 로고
    • The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
    • Okada, T., Sugihara, M., Bondar, A. N., Elstner, M., Entel, P., and Buss, V. (2004) The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J. Mol. Biol. 342, 571-583.
    • (2004) J. Mol. Biol , vol.342 , pp. 571-583
    • Okada, T.1    Sugihara, M.2    Bondar, A.N.3    Elstner, M.4    Entel, P.5    Buss, V.6
  • 11
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • Drews, J. (2000) Drug discovery: A historical perspective. Science 287, 1960-1964.
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 14
    • 0028334663 scopus 로고
    • The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs
    • DeMartino, J. A., Van Riper, G., Siciliano, S. J., Molineaux, C. J., Konteatis, Z. D., Rosen, H., and Springer, M. S. (1994) The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs. J. Biol. Chem. 269, 14446-14450.
    • (1994) J. Biol. Chem , vol.269 , pp. 14446-14450
    • DeMartino, J.A.1    Van Riper, G.2    Siciliano, S.J.3    Molineaux, C.J.4    Konteatis, Z.D.5    Rosen, H.6    Springer, M.S.7
  • 15
    • 0025915252 scopus 로고
    • Identification and synthesis of a receptor binding site of human anaphylatoxin C5a
    • Kawai, M., Quincy, D. A., Lane, B., Mollison, K. W., Luly, J. R., and Carter, G. W. (1991) Identification and synthesis of a receptor binding site of human anaphylatoxin C5a. J. Med. Chem. 34, 2068-2071.
    • (1991) J. Med. Chem , vol.34 , pp. 2068-2071
    • Kawai, M.1    Quincy, D.A.2    Lane, B.3    Mollison, K.W.4    Luly, J.R.5    Carter, G.W.6
  • 16
    • 0028155959 scopus 로고
    • Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor
    • Bubeck, P., Grotzinger, J., Winkler, M., Kohl, J., Wollmer, A., Klos, A., and Bautsch, W. (1994) Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor. Eur. J. Biochem. 219, 897-904.
    • (1994) Eur. J. Biochem , vol.219 , pp. 897-904
    • Bubeck, P.1    Grotzinger, J.2    Winkler, M.3    Kohl, J.4    Wollmer, A.5    Klos, A.6    Bautsch, W.7
  • 18
    • 0028169697 scopus 로고
    • 2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding
    • 2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding. J. Biol. Chem. 269, 3457-3463.
    • (1994) J. Biol. Chem , vol.269 , pp. 3457-3463
    • Mery, L.1    Boulay, F.2
  • 19
    • 0032562684 scopus 로고    scopus 로고
    • Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin
    • Chen, Z., Zhang, X., Gonnella, N. C., Pellas, T. C., Boyar, W. C., and Ni, F. (1998) Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. J. Biol. Chem. 273, 10411-10419.
    • (1998) J. Biol. Chem , vol.273 , pp. 10411-10419
    • Chen, Z.1    Zhang, X.2    Gonnella, N.C.3    Pellas, T.C.4    Boyar, W.C.5    Ni, F.6
  • 20
    • 0035821247 scopus 로고    scopus 로고
    • Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor
    • Farzan, M., Schnitzler, C. E., Vasilieva, N., Leung, D., Kuhn, J., Gerard, C., Gerard, N. P., and Choe, H. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193, 1059-1066.
    • (2001) J. Exp. Med , vol.193 , pp. 1059-1066
    • Farzan, M.1    Schnitzler, C.E.2    Vasilieva, N.3    Leung, D.4    Kuhn, J.5    Gerard, C.6    Gerard, N.P.7    Choe, H.8
  • 21
    • 33846011082 scopus 로고    scopus 로고
    • Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking
    • Hagemann, I. S., Narzinski, K. D., Floyd, D. H., and Baranski, T. J. (2006) Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking. J. Biol. Chem. 281, 36783-36792.
    • (2006) J. Biol. Chem , vol.281 , pp. 36783-36792
    • Hagemann, I.S.1    Narzinski, K.D.2    Floyd, D.H.3    Baranski, T.J.4
  • 22
    • 43149124854 scopus 로고    scopus 로고
    • Structure of the complement factor 5a (C5a) receptor/ligand complex studied by disulfide trapping and molecular modeling
    • E-publication ahead of print: PMID 18195008
    • Hageman, I. S., Miller, D. L., Klco, J. M., Nikiforovich, G. V., and Baranski, T. J. (2008) Structure of the complement factor 5a (C5a) receptor/ligand complex studied by disulfide trapping and molecular modeling, J. Biol. Chem. E-publication ahead of print: PMID 18195008.
    • (2008) J. Biol. Chem
    • Hageman, I.S.1    Miller, D.L.2    Klco, J.M.3    Nikiforovich, G.V.4    Baranski, T.J.5
  • 23
    • 0033609445 scopus 로고    scopus 로고
    • Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand
    • Crass, T., Bautsch, W., Cain, S. A., Pease, J. E., and Monk, P. N. (1999) Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand. Biochemistry 38, 9712-9717.
    • (1999) Biochemistry , vol.38 , pp. 9712-9717
    • Crass, T.1    Bautsch, W.2    Cain, S.A.3    Pease, J.E.4    Monk, P.N.5
  • 24
    • 0029016905 scopus 로고
    • Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus
    • Monk, P. N., Barker, M. D., Partridge, L. J., and Pease, J. E. (1995) Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus. J. Biol. Chem. 270, 16625-16629.
    • (1995) J. Biol. Chem , vol.270 , pp. 16625-16629
    • Monk, P.N.1    Barker, M.D.2    Partridge, L.J.3    Pease, J.E.4
  • 25
    • 0141922889 scopus 로고    scopus 로고
    • Characterisation of C5a receptor agonists from phage display libraries
    • Cain, S. A., Higginbottom, A., and Monk, P. N. (2003) Characterisation of C5a receptor agonists from phage display libraries. Biochem. Pharmacol. 66, 1833-1840.
    • (2003) Biochem. Pharmacol , vol.66 , pp. 1833-1840
    • Cain, S.A.1    Higginbottom, A.2    Monk, P.N.3
  • 26
    • 0030047563 scopus 로고    scopus 로고
    • Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor
    • Raffetseder, U., Roper, D., Mery, L., Gietz, C., Klos, A., Grotzinger, J., Wollmer, A., Boulay, F., Kohl, J., and Bautsch, W. (1996) Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor. Eur. J. Biochem. 235, 82-90.
    • (1996) Eur. J. Biochem , vol.235 , pp. 82-90
    • Raffetseder, U.1    Roper, D.2    Mery, L.3    Gietz, C.4    Klos, A.5    Grotzinger, J.6    Wollmer, A.7    Boulay, F.8    Kohl, J.9    Bautsch, W.10
  • 27
    • 0035923408 scopus 로고    scopus 로고
    • Mapping the ligand-binding site on the C5a receptor: Arginine74 of C5a contacts aspartate282 of the C5a receptor
    • Cain, S. A., Coughlan, T., and Monk, P. N. (2001) Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor. Biochemistry 40, 14047-14052.
    • (2001) Biochemistry , vol.40 , pp. 14047-14052
    • Cain, S.A.1    Coughlan, T.2    Monk, P.N.3
  • 28
    • 0029002999 scopus 로고
    • Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs
    • DeMartino, J. A., Konteatis, Z. D., Siciliano, S. J., Van Riper, G., Underwood, D. J., Fischer, P. A., and Springer, M. S. (1995) Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs. J. Biol. Chem. 270, 15966-15969.
    • (1995) J. Biol. Chem , vol.270 , pp. 15966-15969
    • DeMartino, J.A.1    Konteatis, Z.D.2    Siciliano, S.J.3    Van Riper, G.4    Underwood, D.J.5    Fischer, P.A.6    Springer, M.S.7
  • 30
    • 0035877281 scopus 로고    scopus 로고
    • Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor
    • Cain, S. A., Woodruff, T. M., Taylor, S. M., Fairlie, D. P., Sanderson, S. D., and Monk, P. N. (2001) Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor. Biochem. Pharmacol. 61, 1571-1579.
    • (2001) Biochem. Pharmacol , vol.61 , pp. 1571-1579
    • Cain, S.A.1    Woodruff, T.M.2    Taylor, S.M.3    Fairlie, D.P.4    Sanderson, S.D.5    Monk, P.N.6
  • 31
    • 0035793604 scopus 로고    scopus 로고
    • An activation switch in the ligand binding pocket of the C5a receptor
    • Gerber, B. O., Meng, E. C., Dotsch, V., Baranski, T. J., and Bourne, H. R. (2001) An activation switch in the ligand binding pocket of the C5a receptor. J. Biol. Chem. 276, 3394-3400.
    • (2001) J. Biol. Chem , vol.276 , pp. 3394-3400
    • Gerber, B.O.1    Meng, E.C.2    Dotsch, V.3    Baranski, T.J.4    Bourne, H.R.5
  • 32
    • 28444450565 scopus 로고    scopus 로고
    • Modeling flexible loops in the dark-adapted and activated states of rhodopsin, a prototypical G-protein coupled receptor
    • Nikiforovich, G. V., and Marshall, G. R. (2005) Modeling flexible loops in the dark-adapted and activated states of rhodopsin, a prototypical G-protein coupled receptor. Biophys. J. 89, 3780-3789.
    • (2005) Biophys. J , vol.89 , pp. 3780-3789
    • Nikiforovich, G.V.1    Marshall, G.R.2
  • 33
    • 34047246323 scopus 로고    scopus 로고
    • A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues
    • Matsumoto, M. L., Narzinski, K., Kiser, P. D., Nikiforovich, G. V., and Baranski, T. J. (2007) A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues. J. Biol. Chem. 282, 3105-3121.
    • (2007) J. Biol. Chem , vol.282 , pp. 3105-3121
    • Matsumoto, M.L.1    Narzinski, K.2    Kiser, P.D.3    Nikiforovich, G.V.4    Baranski, T.J.5
  • 34
    • 34247550299 scopus 로고    scopus 로고
    • Modeling of the complex between transducin and photoactivated rhodopsin, a prototypical G-protein-coupled receptor
    • Nikiforovich, G. V., Taylor, C. M., and Marshall, G. R. (2007) Modeling of the complex between transducin and photoactivated rhodopsin, a prototypical G-protein-coupled receptor. Biochemistry 46, 4734-4744.
    • (2007) Biochemistry , vol.46 , pp. 4734-4744
    • Nikiforovich, G.V.1    Taylor, C.M.2    Marshall, G.R.3
  • 35
    • 0000948942 scopus 로고
    • Energy parameters in polypeptides. 8. Empirical potential energy algorithm for the conformational analysis of large molecules
    • Dunfield, L. G., Burgess, A. W., and Scheraga, H. A. (1978) Energy parameters in polypeptides. 8. Empirical potential energy algorithm for the conformational analysis of large molecules. J. Phys. Chem. 82, 2609-2616.
    • (1978) J. Phys. Chem , vol.82 , pp. 2609-2616
    • Dunfield, L.G.1    Burgess, A.W.2    Scheraga, H.A.3
  • 36
    • 33845550595 scopus 로고
    • Energy parameters in polypeptides. 9. Updating of geometrical parameters, nonbonded interactions, and hydrogen bond interactions for the naturally occuring amino acids
    • Nemethy, G., Pottle, M. S., and Scheraga, H. A. (1983) Energy parameters in polypeptides. 9. Updating of geometrical parameters, nonbonded interactions, and hydrogen bond interactions for the naturally occuring amino acids. J. Phys. Chem. 87, 1883-1887.
    • (1983) J. Phys. Chem , vol.87 , pp. 1883-1887
    • Nemethy, G.1    Pottle, M.S.2    Scheraga, H.A.3
  • 37
    • 0027996724 scopus 로고
    • Computational molecular modeling in peptide design
    • Nikiforovich, G. V. (1994) Computational molecular modeling in peptide design. Int. J. Pept. Protein Res. 44, 513-531.
    • (1994) Int. J. Pept. Protein Res , vol.44 , pp. 513-531
    • Nikiforovich, G.V.1
  • 38
    • 0028201342 scopus 로고
    • C5A anaphylatoxin and its seven transmembrane-segment receptor
    • Gerard, C., and Gerard, N. P. (1994) C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12, 775-808.
    • (1994) Annu. Rev. Immunol , vol.12 , pp. 775-808
    • Gerard, C.1    Gerard, N.P.2
  • 40
    • 0026191334 scopus 로고
    • Topographical requirements for delta-selective opioid peptides
    • Nikiforovich, G. V., Hruby, V. J., Prakash, O., and Gehrig, C. A. (1991) Topographical requirements for delta-selective opioid peptides. Biopolymers 31, 941-955.
    • (1991) Biopolymers , vol.31 , pp. 941-955
    • Nikiforovich, G.V.1    Hruby, V.J.2    Prakash, O.3    Gehrig, C.A.4
  • 41
    • 0030946317 scopus 로고    scopus 로고
    • Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity
    • Finch, A. M., Vogen, S. M., Sherman, S. A., Kirnarsky, L., Taylor, S. M., and Sanderson, S. D. (1997) Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity. J. Med. Chem. 40, 877-884.
    • (1997) J. Med. Chem , vol.40 , pp. 877-884
    • Finch, A.M.1    Vogen, S.M.2    Sherman, S.A.3    Kirnarsky, L.4    Taylor, S.M.5    Sanderson, S.D.6
  • 42
    • 0005189315 scopus 로고    scopus 로고
    • Determination of structural elements related to the biological activities of a potent decapeptide agonist of human C5a anaphylatoxin
    • Vogen, S. M., Prakash, O., Kirnarsky, L., Sanderson, S. D., and Sherman, S. A. (1999) Determination of structural elements related to the biological activities of a potent decapeptide agonist of human C5a anaphylatoxin. J. Pept. Res. 54, 74-84.
    • (1999) J. Pept. Res , vol.54 , pp. 74-84
    • Vogen, S.M.1    Prakash, O.2    Kirnarsky, L.3    Sanderson, S.D.4    Sherman, S.A.5
  • 43
    • 0018077302 scopus 로고
    • Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a
    • Fernandez, H. N., and Hugh, T. E. (1978) Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a. J. Biol. Chem. 253, 6955-6964.
    • (1978) J. Biol. Chem , vol.253 , pp. 6955-6964
    • Fernandez, H.N.1    Hugh, T.E.2
  • 44
    • 33744959047 scopus 로고    scopus 로고
    • Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop
    • Klco, J. M., Nikiforovich, G. V., and Baranski, T. J. (2006) Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop. J. Biol. Chem. 281, 12010-12019.
    • (2006) J. Biol. Chem , vol.281 , pp. 12010-12019
    • Klco, J.M.1    Nikiforovich, G.V.2    Baranski, T.J.3
  • 45
    • 0032609833 scopus 로고    scopus 로고
    • The influence of Lys68 in decapeptide agonists of C5a on C5a receptor binding, activation and selectivity
    • Vogen, S. M., Finch, A. M., Wadi, S. K., Thatcher, J., Monk, P. N., Taylor, S. M., and Sanderson, S. D. (1999) The influence of Lys68 in decapeptide agonists of C5a on C5a receptor binding, activation and selectivity. J. Pept. Res. 53, 8-17.
    • (1999) J. Pept. Res , vol.53 , pp. 8-17
    • Vogen, S.M.1    Finch, A.M.2    Wadi, S.K.3    Thatcher, J.4    Monk, P.N.5    Taylor, S.M.6    Sanderson, S.D.7
  • 46
    • 0036510770 scopus 로고    scopus 로고
    • The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
    • Cain, S. A., and Monk, P. N. (2002) The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J. Biol. Chem. 277, 7165-7169.
    • (2002) J. Biol. Chem , vol.277 , pp. 7165-7169
    • Cain, S.A.1    Monk, P.N.2
  • 50
    • 30644458763 scopus 로고    scopus 로고
    • Homology modeling of opioid receptor-ligand complexes using experimental constraints
    • Pogozheva, I. D., Przydzial, M. J., and Mosberg, H. I. (2005) Homology modeling of opioid receptor-ligand complexes using experimental constraints. AAPS J. 7, E434-E448.
    • (2005) AAPS J , vol.7
    • Pogozheva, I.D.1    Przydzial, M.J.2    Mosberg, H.I.3
  • 52
    • 22844442348 scopus 로고    scopus 로고
    • Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay
    • Clement, M., Martin, S. S., Beaulieu, M. E., Chamberland, C., Lavigne, P., Leduc, R., Guillemette, G., and Escher, E. (2005) Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay. J. Biol. Chem. 280, 27121-27129.
    • (2005) J. Biol. Chem , vol.280 , pp. 27121-27129
    • Clement, M.1    Martin, S.S.2    Beaulieu, M.E.3    Chamberland, C.4    Lavigne, P.5    Leduc, R.6    Guillemette, G.7    Escher, E.8
  • 53
    • 34248591811 scopus 로고    scopus 로고
    • The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure
    • Oliveira, L., Costa-Neto, C. M., Nakaie, C. R., Schreier, S., Shimuta, S. I., and Paiva, A. C. (2007) The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure. Physiol. Rev. 87, 565-592.
    • (2007) Physiol. Rev , vol.87 , pp. 565-592
    • Oliveira, L.1    Costa-Neto, C.M.2    Nakaie, C.R.3    Schreier, S.4    Shimuta, S.I.5    Paiva, A.C.6
  • 54
    • 37349115217 scopus 로고    scopus 로고
    • Model of the angiotensin II type-2 receptor for exploring the binding mode of angiotensin II and pseudopeptide analogues
    • Sköld, C., Nikiforovich, G. V., and Karlen, A. (2008) Model of the angiotensin II type-2 receptor for exploring the binding mode of angiotensin II and pseudopeptide analogues, J. Mol. Graphics Modell. 26, 991-1003.
    • (2008) J. Mol. Graphics Modell , vol.26 , pp. 991-1003
    • Sköld, C.1    Nikiforovich, G.V.2    Karlen, A.3
  • 55
    • 0034805794 scopus 로고    scopus 로고
    • 3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data
    • Nikiforovich, G. V., and Marshall, G. R. (2001) 3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data. Biochem. Biophys. Res. Commun. 286, 1204-1211.
    • (2001) Biochem. Biophys. Res. Commun , vol.286 , pp. 1204-1211
    • Nikiforovich, G.V.1    Marshall, G.R.2
  • 56
    • 33745216928 scopus 로고    scopus 로고
    • Insight into the binding mode for cyclopentapeptide antagonists of the CXCR4 receptor
    • Vabeno, J., Nikiforovich, G. V., and Marshall, G. R. (2006) Insight into the binding mode for cyclopentapeptide antagonists of the CXCR4 receptor. Chem. Biol. Drug Des. 67, 346-354.
    • (2006) Chem. Biol. Drug Des , vol.67 , pp. 346-354
    • Vabeno, J.1    Nikiforovich, G.V.2    Marshall, G.R.3
  • 57
    • 33646111925 scopus 로고    scopus 로고
    • Molecular docking-based study of vasopressin analogues modified at positions 2 and 3 with N-methylphenylalanine: Influence on receptor-bound conformations and interactions with vasopressin and oxytocin receptors
    • Slusarz, M. J., Sikorska, E., Slusarz, R., and Ciarkowski, J. (2006) Molecular docking-based study of vasopressin analogues modified at positions 2 and 3 with N-methylphenylalanine: Influence on receptor-bound conformations and interactions with vasopressin and oxytocin receptors. J. Med. Chem. 49, 2463-2469.
    • (2006) J. Med. Chem , vol.49 , pp. 2463-2469
    • Slusarz, M.J.1    Sikorska, E.2    Slusarz, R.3    Ciarkowski, J.4
  • 58
    • 33645698998 scopus 로고    scopus 로고
    • Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: Molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system
    • Slusarz, M. J., Slusarz, R., and Ciarkowski, J. (2006) Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: Molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers 81, 321-338.
    • (2006) Biopolymers , vol.81 , pp. 321-338
    • Slusarz, M.J.1    Slusarz, R.2    Ciarkowski, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.