Toxicokinetic study of recombinant human heparin-binding epidermal growth factor-like growth factor (rhHB-EGF) in female Sprague Dawley rats

Pharmaceutical Research

Volumn 25, Issue 3, 2008, Pages 542-550

  Coowanitwong, Intira ^a   Keay, Susan K ^b,c   Natarajan, Karthika ^a   Garimella, Tushar S ^a   Mason, Clifford W ^a   Grkovic, David ^c   Bauer, Kenneth S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

HB EGF; Interstitial cystitis; Intrabladder instillation; Intravenous administration pharmacokinetics; NONMEM; Toxicity; Toxicokinetics

Indexed keywords

HEPARIN BINDING EPIDERMAL GROWTH FACTOR; IODINE 125; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AUTOPSY; BLADDER IRRIGATION; BLOOD CHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; INTERSTITIAL CYSTITIS; LYMPHOCYTIC INFILTRATION; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ADMINISTRATION, INTRAVESICAL; ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; IODINE RADIOISOTOPES; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; URINARY BLADDER;

EID: 40549099063     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9392-3     Document Type: Article

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